The University Of Texas Health Science Center At San Antonio

This study tests whether adding raloxifene to memantine can help preserve memory in adults receiving radiation for brain tumors. About 108 participants will be followed with MRI scans to track changes in the brain's memory center. The goal is to delay or prevent cognitive decline…

This early-phase trial tests the safety and effects of a new drug called MCAM in healthy adults. In Part A, 39 participants receive a single dose of MCAM or a placebo to measure blood levels and safety. In Part B, people who have used opioids before will test how quickly and how …

This study looks at whether adding pioglitazone (a type 2 diabetes drug) to dapagliflozin (an SGLT2 inhibitor) can reduce the liver's glucose production, fat breakdown, and ketone production in people with type 1 diabetes. These effects from dapagliflozin can raise the risk of ke…

This study tests whether taking branched-chain amino acids (the building blocks of protein) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease who also have muscle loss (sarcopenia). Participants will take the supplements for …

This early-stage study tests whether bupropion, a medicine used for smoking cessation and depression, can reduce severe tiredness in people with end-stage kidney disease on dialysis. Sixteen participants will take bupropion three times a week for 8 weeks and report their fatigue …

This study tests a web-based program called SCIPI that gives men newly diagnosed with prostate cancer easy-to-understand information, tools for talking with doctors, and social support. About 200 participants will be randomly assigned to use SCIPI or receive usual care. The goal …

This study tests whether a short, one-on-one Crisis Response Planning session can help prevent suicide in active-duty military personnel who have had a mild traumatic brain injury (concussion). About 120 participants will either receive CRP or standard care, and researchers will …

This study tests whether a medicated mist (nebulized tranexamic acid) can safely stop bleeding in children after tonsil removal. About 30 kids aged 2 to 17 who experience bleeding will receive the mist instead of going back to the operating room. The goal is to see if this approa…

This study tests a 6-week exercise program called SwallowFit to see if it can improve swallowing fitness in people with Parkinson's disease. Researchers will compare the exercise group to those receiving standard care. The goal is to help participants swallow better and improve t…

This study tests a smartphone app called KIOS designed to help people recovering from opioid addiction manage their health. Researchers will track how well participants stay in treatment over one year and who benefits most from the app. About 134 adults who recently started bupre…

This study tests a program called FORT that helps active-duty military personnel manage long-term muscle and joint pain. About 480 participants will take part across six military hospitals. The goal is to see if the program reduces pain and improves daily function, and to underst…

This study tests whether a device that gently stimulates a nerve in the ear is safe and practical for people with moderate to severe traumatic brain injury. Sixteen adults will receive either real or sham stimulation. The main goal is to check safety and feasibility, while also e…

This study aims to discover rare genetic changes that make people more likely to develop cancer. Researchers will collect blood, saliva, and tumor samples from 100 participants who have had multiple cancers or have a strong family history of cancer, along with their relatives. By…