The University Of Texas Health Science Center At San Antonio

This study tests whether regular sessions of passive heat therapy (like sitting in a warm room or bath) can improve blood vessel health in people with spinal cord injury. About 48 adults will either receive heat therapy or a placebo for 60 minutes, 4 times a week for 8 weeks, mos…

This study tests whether a gel made from enamel proteins can thicken gum tissue around dental implants. Researchers will measure gum thickness in 32 adults who need implant uncovering surgery. The goal is to see if this treatment leads to healthier, stronger gums around implants.

This study tests a mobile program called Quitxt that sends texts and videos to help young Latino smokers (ages 18-29) quit. About 1,200 participants will be split into two groups: one gets Quitxt, the other gets basic quit-smoking texts. Researchers will check if they've quit at …

This study tests whether surgery to remove both the main pancreatic tumor and small tumors in the liver or lungs can help people whose cancer has spread only a little. Everyone gets the same chemotherapy (NALIRIFOX) before surgery. If the cancer shrinks or stays stable after 4 cy…

This early-stage study tests whether adding the drug avasopasem to standard hormone therapy and a CDK 4/6 inhibitor is safe and can better control metastatic HR+ breast cancer. About 35 women whose cancer has worsened on current treatments will participate. The goal is to see if …

This study looks at how well a special glass fiber dressing works for diabetic foot ulcers that also have a bone infection. About 20 adults with diabetes will be watched as they get this standard treatment. The goal is to see if the dressing helps wounds close fully, reduces pain…

This study looks at two methods to preserve the jawbone after a tooth is pulled. After extraction, the bone can shrink, so a graft is placed in the socket to maintain bone volume for a future dental implant. Researchers will compare a synthetic calcium apatite material in a colla…

This study is testing a new treatment called IR-TMS, which uses magnetic fields to target specific parts of the brain, to see if it can help people with Alcohol Use Disorder reduce their drinking. About 150 participants will receive several sessions of this brain stimulation, alo…

This study tests a drug called sacituzumab govitecan in people whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug targets a protein called Trop-2 found on tumor cells. Researchers want to see if it helps patients live longer compared to o…

This study tests two different drug combinations in people recently diagnosed with type 2 diabetes. One group gets pioglitazone plus tirzepatide, the other gets metformin plus sitagliptin. The goal is to see which combo lowers blood sugar better and for longer. About 256 adults a…

This study tests a combination of two immunotherapy drugs (tremelimumab and durvalumab) in 32 people with advanced liver cancer who also have moderate cirrhosis (Child-Pugh B). The main goal is to see if the treatment is safe and tolerable, and to measure how well it shrinks tumo…

This study tests low-cost treatments to help Hispanic adults with prediabetes and obesity bring blood sugar back to normal, lose weight, and lower heart disease risk. Researchers will measure changes in blood sugar, body fat, and heart function. The goal is to find affordable str…

This early-stage study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and brain fog in people with end-stage kidney disease. About 28 adults on regular hemodialysis will receive either a single amino acid (valine) or a mix of essential am…

This study compares two types of talk therapy for insomnia in 160 active-duty military members who have had a mild traumatic brain injury and still have symptoms like trouble sleeping, thinking, or mood issues. One therapy is longer (6 sessions) and the other is shorter (4 sessio…

This study looks at whether doing intense aerobic exercise before virtual reality training can improve balance and help the brain adapt better in people with Parkinson's disease. Sixteen participants will be split into two groups: one does high-intensity exercise plus VR, the oth…

This study tests whether adding a stellate ganglion block (a numbing injection in the neck) to intensive talk therapy helps reduce PTSD symptoms more than therapy alone. About 140 military members or retirees with PTSD will receive ten 90-minute therapy sessions, plus either the …

This study looks at how deep brain stimulation (DBS) affects sleep and movement in people with Parkinson's disease. Twenty participants who already have a DBS device will spend two nights in a sleep lab—one night with the device on and one with it off. Researchers will measure sl…

This study tests whether a gentle brain stimulation technique called tDCS, used daily at home, can help with behavioral and thinking problems in Huntington's disease. Sixteen adults with early to moderate Huntington's will use a head device for 30 minutes each day and answer ques…

This early study tests if a medicated mist (nebulized tranexamic acid) can safely stop bleeding after a child's tonsils are removed. About 12 children aged 2 to 17 who have bleeding after tonsillectomy will receive the mist. The goal is to see if this approach can avoid the need …

This study compares two antipsychotic drugs, pimavanserin and quetiapine, to see which works better for treating hallucinations and delusions in people with Parkinson's disease or dementia with Lewy bodies. About 94 participants will be randomly assigned to one of the two medicat…

This study tests if transcranial magnetic stimulation (TMS) is a safe and helpful treatment for teens aged 12-20 who still have PTSD symptoms after finishing talk therapy. About 20 participants will receive 10 TMS sessions over a month. The goal is to see if TMS reduces symptoms …

This study looks at ways to help veterans with PTSD who are not getting better from their first treatment. Researchers will test if switching to a different therapy or adding text message reminders for homework helps improve symptoms. About 302 veterans will take part, and the go…

This study tests whether low-frequency ultrasound baths can improve muscle strength, thinking skills, and immune health in healthy adults aged 70 and older. Twenty participants will either receive ultrasound baths three times a week for 8 weeks or sit in a bath without ultrasound…

This study tests a new exercise method for people with Parkinson's disease. Researchers will see if partially restricting blood flow to the legs during balance-challenging strength exercises can improve symptoms. The study involves 20 participants aged 40 to 85 and focuses on whe…

This study enrolls 525 veterans and active-duty service members with chronic headaches after a traumatic brain injury. It compares in-person cognitive behavioral therapy, the same therapy via telemedicine, and usual care to see which best reduces headache-related disability. The …

This study tests a new treatment for anger and aggression caused by past betrayal during military service. It will include 40 active duty service members and veterans. Participants will complete 14 treatment modules twice a week and fill out surveys before, during, and after the …

This study tests whether using a microscope during gum surgery helps the gums heal better than using standard dental loupes (magnifying glasses). About 25 adults with gum disease will take part. Researchers will check early wound healing and compare how long the stitching takes w…

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep quality, mood, fatigue, and signs of inflammation in 276 participants over 20 weeks. The goal is to find a simple,…

This study tests whether a non-invasive device that sends a mild electrical current to the brain (tDCS) can improve mood, reduce apathy, and ease other emotional symptoms in people with Alzheimer's disease. Researchers will have 24 participants use the device at home for 30-minut…

This study tests whether special listening exercises can improve hearing for people who have had a mild traumatic brain injury (mTBI). Many with mTBI struggle to hear clearly in noisy places or tell where sounds come from. The training has helped healthy people, and researchers w…

This study tests a new type of talk therapy for veterans and active service members who have both PTSD and a mild or moderate traumatic brain injury (TBI). The therapy focuses on managing PTSD symptoms without asking participants to relive their traumatic experiences. The study w…

This study looks at how tirzepatide, a weight-loss drug, affects muscle mass and strength in adults aged 50 and older with obesity. Researchers want to know if losing weight with this drug also causes harmful muscle loss that could lead to frailty. Twenty participants will take t…

This study watches 84 people with advanced liver cancer that cannot be removed by surgery. It focuses on adults 65 and older to learn how the disease changes over time and how treatments affect them. Researchers will use simple health checklists and track side effects. The goal i…

This study looks at how giving DHA and ARA (types of healthy fats) to very premature babies affects their fat metabolism and body development. Researchers will measure changes in blood fats and other markers related to growth and inflammation. The goal is to understand how these …

This study looks at how dupilumab changes the way the nose and blood respond to house dust mites in adults with allergic asthma. Participants will be exposed to dust mites in a special chamber and receive either dupilumab or a placebo. The goal is to understand the drug's effects…

This study looks at how a ketogenic diet affects the area around breast cancer tumors. Twelve women with early-stage breast cancer will follow the diet for three weeks before their surgery. Researchers will measure changes in immune cells and ketone levels to see if the diet infl…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…

This study looks at whether 3D X-rays (CBCT) can help dentists decide when it's safe to place a dental implant after sinus surgery. About 25 adults who need a sinus lift for an implant will get a 3D scan right after surgery and again 6 months later. The goal is to measure how muc…

This early-phase study is testing whether a drink containing ketones can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days while researchers measure heart efficiency wi…

This study looks at how two types of weight-loss surgery—gastric bypass and sleeve gastrectomy—change the way the body handles sugar after a meal. Researchers will measure insulin levels in 200 people, including those who had surgery and healthy volunteers. The goal is to underst…

This study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use energy from ketones. Researchers want to see if these changes can improve exercise ability and daily function in 30 adults with type 2 diabetes and heart failure. Participan…

This study is gathering medical and educational information from up to 4,000 people with chromosome 18 abnormalities and their families. The goal is to better understand these rare conditions and provide better resources and care. Participants must be at least one year old and in…

This study creates a living collection of miniature lung cancer models (organoids) from 150 patients with stage I-III lung cancer. Researchers will test how these organoids respond to chemotherapy and targeted drugs, comparing results to how patients actually respond. The goal is…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which brain networks are involved. The goal is to learn how therapy works in the brain, which cou…

This study looks at how the hormone glucagon affects blood sugar in people who have had bariatric surgery and those who haven't. Researchers will use an investigational drug called REMD-477 to block glucagon and measure changes in glucose metabolism. The goal is to better underst…

This study looks at the genes of people with rare nervous system tumors called pheochromocytoma and paraganglioma. Researchers want to find the genetic causes and link them to specific symptoms. Up to 2,000 patients and their family members will provide DNA samples to help improv…

This study looks at how two diabetes medicines interact in the body. Researchers want to see if pioglitazone can prevent the rise in ketones that sometimes happens with empagliflozin. The study involves 64 adults with type 2 diabetes and uses special tracers to measure sugar and …

This study looks at how the liver uses energy in people with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Researchers will measure liver metabolism before and after 16 weeks of treatment with the diabetes drug pioglitazone. About 60 adults aged 18-80 with stable …

This study looks at whether a special training program called Acceptance and Commitment Training (ACT) can help soldiers handle stress better and stay ready for tough missions. About 600 soldiers from the 3rd Security Force Assistance Brigade will take part. Researchers will comp…

This study looks at how well smart pumps that connect to electronic health records work in 8 adult intensive care units. Researchers will interview nurses, review pump data, and run simulations to understand if the technology reduces errors and is easy to use. About 659 nurses an…

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study aims to understand how gastric bypass surgery helps control blood sugar and leads to weight loss. Researchers will measure gut hormones, especially GLP-1, in 80 adults who have had the surgery, including some with low blood sugar episodes. The goal is to learn which ho…

This study looks at why some people who had gastric bypass surgery develop very low blood sugar years later, while others see their type 2 diabetes improve. Researchers will measure gut hormones and nerve signals to understand how the surgery changes insulin release. The study in…

This study tests two drugs, rapamycin and everolimus, in healthy adults aged 65-90 to find doses that safely reduce age-related cell changes. Researchers will measure drug levels and activity in blood, fat, and muscle. The goal is to learn how to mimic younger cellular function, …