Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tests a precise, one-time radiation treatment for people with a dangerous heart rhythm called ventricular tachycardia that hasn't improved with medication or standard procedures. The goal is to see if this approach can cut the number of severe episodes by at least half…

This study is for people with familial adenomatous polyposis (FAP) who have had their colon removed. It tests a personalized plan to regularly check and treat any new polyps in the remaining bowel. The goal is to keep the risk of advanced polyps or cancer very low (under 5% over …

This study aims to see if a personalized schedule for checking and treating polyps in the stomach and duodenum can prevent cancer in people with familial adenomatous polyposis (FAP). About 1,000 adults with FAP will receive endoscopies and polyp removal based on their individual …

Some people with long COVID have symptoms like extreme fatigue because their immune system attacks their own body. This study tests a treatment called immunoadsorption, which filters the blood to remove harmful antibodies. About 70 adults with long COVID and these antibodies will…

This study tests a procedure called bronchial thermoplasty (BT) for people with severe asthma that remains uncontrolled even with biologic drugs. BT uses a thin tube to deliver heat to the airway walls, aiming to reduce asthma attacks and improve quality of life. About 90 adults …

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This study tests whether using lung ultrasound to guide removal of extra fluid helps patients on breathing machines in the ICU breathe on their own sooner. About 1,000 adults who need a ventilator for at least another day will be randomly assigned to have fluid removal guided by …

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests a shorter, more intense radiation schedule combined with chemotherapy for people with locally advanced esophageal cancer. The goal is to see if this approach is safe and feasible, and to reduce side effects like low white blood cell counts. About 60 adults will r…

This study tests a procedure called duodenal mucosal resurfacing (DMR) for people with type 2 diabetes who take non-insulin medications. The treatment uses a thin tube to treat the lining of the upper gut, aiming to improve blood sugar control. The trial compares DMR to a sham (f…

This study tests whether a drug-coated balloon can reduce the fat content of dangerous plaques in heart arteries better than standard medications alone. It includes 400 adults who recently had a heart problem called acute coronary syndrome. Participants will be randomly assigned …

This study tests whether ziltivekimab, an anti-inflammatory drug, can reduce swelling in the heart's arteries. About 40 adults with heart disease and high inflammation will receive either the drug or a placebo. Researchers will use special scans and blood tests to see if the drug…

This study tests whether early, aggressive cholesterol-lowering therapy can shrink artery plaques in 60 young adults (under 50) with familial high cholesterol. Participants will receive intensive treatment and have their plaque levels measured with CT scans. The goal is to see if…

This study looks at people with esophageal or stomach cancer that has spread to only a few spots (oligometastases). All participants receive 4 months of standard drug therapy, then are randomly assigned to either get local treatment (surgery or radiation) right away or after anot…

This study tests whether using lung ultrasound to personalize ventilator settings can reduce deaths in patients with acute respiratory distress syndrome (ARDS), a severe lung condition with about 30% mortality. About 538 adults on breathing machines will be randomly assigned to s…

This study tests if people with well-controlled eczema can safely take their dupilumab injections less often. 216 adults will be randomly assigned to receive the drug every 2, 3, or 4 weeks. Researchers will compare eczema severity and quality of life to see if longer intervals w…

This trial tests whether giving three treatments together—two medicines and a surgical patch—can lower the risk of major complications after Whipple surgery for pancreatic cancer and other tumors. The study includes 400 high-risk patients with a small pancreatic duct. If successf…

This study tests whether adding a blood test called presepsin to standard care can safely reduce the number of preterm babies (born before 32 weeks) who receive antibiotics unnecessarily. Currently, over 85% of these infants get antibiotics right after birth due to infection risk…

This study tests whether using heat (radiofrequency ablation) before placing a metal stent helps keep the bile duct open longer in people with inoperable bile duct cancer. About 122 adults with this cancer will be randomly assigned to get the heat treatment plus a stent or just a…

This study tests a portable EEG device called StrokePointer that ambulance crews can use to quickly identify stroke patients who need to go directly to a hospital equipped for specialized clot-removal treatment. The goal is to reduce the average one-hour delay caused when patient…

This study tests whether fluvoxamine, an antidepressant, can reduce severe fatigue and other symptoms in people with post-COVID. 160 adults aged 18-70 with long-lasting fatigue after COVID will receive either the drug or a placebo for 12 weeks. The goal is to see if it improves e…

This study compares a newer, adaptive form of deep brain stimulation (aDBS) to the standard continuous stimulation (cDBS) in 130 people with Parkinson's disease. The goal is to see if aDBS increases the amount of time during the day when symptoms are well-controlled without causi…

This study looks at whether a program of exercise and dietary changes can improve or maintain quality of life for people with incurable stomach or esophageal cancer. About 196 participants will either receive standard care or standard care plus the exercise and nutrition program.…

This study compares two minimally invasive surgeries—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign (non-cancerous) or pre-cancerous growths. About 256 adults will be randomly assigned to one of the two procedures. The goal is to …

This study tests whether using virtual reality (VR) to simulate the workplace helps cabin crew on sick leave for mental health issues return to work sooner. 118 participants will either get standard care or standard care plus at least one VR session. The goal is to see if VR redu…

This study follows over 3,000 people with low-risk Barrett's esophagus who have stopped having routine endoscopic surveillance, as recommended by new guidelines. Researchers will track them for at least 10 years to see if stopping these scopes leads to a rise in serious esophagea…

This study looks at whether removing the spleen during surgery for left-sided pancreatic cancer is always necessary. Currently, the spleen is taken out to remove any hidden cancer cells in the surrounding fat, but this can cause extra risks. By checking how often cancer actually …

This study aims to understand why Crohn's disease often comes back after surgery by looking at specific immune cells that respond to a protein called IL-23. Researchers will collect tissue samples from 40 adults with Crohn's who have had surgery and are receiving standard biologi…

This study follows 1,000 people with type 2 diabetes who have already had a heart CT scan. Researchers will repeat the scan to measure how fatty plaque builds up in heart arteries over time. The goal is to better understand who is at highest risk for heart attacks and improve fut…

This study looks at whether using a tilt-table test, along with biofeedback training, can help people who faint due to vasovagal syncope. About 238 adults will be randomly assigned to either biofeedback with the tilt-table test or biofeedback alone. The goal is to see if the test…

This study looks at how a condition called left ventricular diastolic dysfunction (stiff heart muscle) affects recovery in women after heart surgery. Researchers will track 1,000 patients to compare outcomes between men and women. The goal is to find ways to improve results for w…

This study observes 150 ICU patients who need excess fluid removed. Researchers will track how fast and when fluid is removed, and look for signs of success or side effects like low blood pressure. The goal is to find safer, more personalized fluid removal methods, but this study…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…

This study looks at how the liver responds to a sugar injection during weight-loss surgery in 40 obese adults, some with fatty liver disease (MASLD) and some without. Researchers take small liver and fat samples before and after giving sugar or salt water to see which genes turn …

This study looks at whether additional lab tests, like fT3 and the fT3/fT4 ratio, can better measure thyroid hormone status in people with hypothyroidism who take levothyroxine. Researchers will compare these tests in 500 patients and healthy controls. The goal is to improve diag…

This study looks at people who faint (syncope) and are at low or medium risk for serious heart problems. It compares two common approaches: sending them home right away or keeping them in the hospital for 24 hours with heart monitoring. The goal is to find out which approach is s…