Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tests whether icosapent ethyl, a purified fish oil medication, can slow the buildup of calcium in the aortic valve. About 110 adults with mild-to-moderate aortic valve stenosis will take the drug or a placebo. The main goal is to see if the drug reduces the rate of val…

This study tests whether adding intravenous immunoglobulin (IVIg) to standard steroid treatment early in myositis can reduce disease activity and prevent long-term disability. It includes 44 adults with recent-onset myositis (diagnosed within the past year) who have at least mild…

This study compares three different chemotherapy combinations for people with advanced esophageal or stomach cancer that has spread or cannot be removed by surgery. The goal is to find which combination works best to keep the cancer from growing while causing the fewest nerve-rel…

This study tests whether adding narrowband UVB phototherapy (a type of light treatment) to standard topical creams works better than creams alone for adults with moderate atopic eczema. About 316 participants will be randomly assigned to receive either 8-16 weeks of UVB plus opti…

This study tests a new procedure that uses gentle electric pulses to regenerate the lining of the small intestine in people with type 2 diabetes who currently need insulin. The goal is to see if this treatment, combined with a diabetes drug called semaglutide, can help them safel…

This study tests a new device called Endosign that collects tissue samples from the esophagus using a simple pill-on-a-string, instead of a full endoscopy. It includes 60 adults with Barrett's esophagus, a condition that can lead to esophageal cancer. The goal is to see if this l…

This study tests a therapy called imagery rescripting (ImRs) in 8 people with early psychosis. The goal is to see if it improves core beliefs, wellbeing, and self-esteem. Participants receive 4-6 therapy sessions over a few weeks and are followed for 3 more weeks. This is a very …

This study looks at how combining blood tests (proteomics and genomics) with CT scans can help predict the worsening of coronary artery disease. Researchers will follow 310 adults aged 50-75 who have early signs of plaque in their heart arteries but no symptoms. The goal is to be…

This study brings together 40 international experts to agree on a clear definition of lung complications that can happen after surgery. They will also rank these complications by severity and decide the best ways to monitor patients. The goal is to help doctors catch problems ear…

This study looks at whether people who have been bitten many times by ticks can develop a natural resistance. Researchers will compare tick-feeding in people with a history of tick bites to those who have rarely been bitten. The goal is to understand how the body reacts to tick b…

This study tests whether adding a special microscope (nCLE) to a standard lung biopsy procedure can better confirm that the biopsy needle is inside a lung nodule. About 25 adults with suspicious lung nodules will have two needle punctures, each followed by both nCLE imaging and a…