Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tests whether giving extra oxygen in a special chamber (hyperbaric oxygen therapy) can help treat infected bone fractures that are hard to heal. About 50 adults with infected leg fractures will receive either standard care alone or standard care plus oxygen sessions. T…

This study will test a new way to manage heart disease risk using a digital program led by nurses. About 750 adults with heart disease or related conditions will use home monitoring and answer questionnaires. The goal is to see if this approach helps more people reach their chole…

This study tests whether 3D-printed hand braces work as well as traditional custom-made braces for people with long-term hand problems. About 100 adults with stable hand conditions will use either a 3D-printed or conventional brace for daily activities. Researchers will measure h…

This study tests whether a smartphone app can improve quality of life for teenagers with painful or heavy periods. About 874 teens who have started their periods will use the app and report their symptoms. The goal is to see if the app helps them feel better and manage their mens…

This study tests whether a new splintless surgical technique is more accurate than the standard splint-based method for moving the jaw forward to treat obstructive sleep apnea in adults. About 66 patients with moderate to severe sleep apnea who cannot use a CPAP machine will be r…

This study watches 60 adults who had jaw surgery for obstructive sleep apnea. Some develop a different type of apnea after surgery. The goal is to see if these new breathing pauses get better, stay the same, or go away over time. Participants will have sleep tests months after su…

This study will observe 15,000 adults having heart surgery at hospitals worldwide. Researchers will collect information on anesthesia, heart-lung machine use, and surgical techniques to see which methods lead to the best recoveries. The goal is to fill gaps in current guidelines …

This study looks at how often speech and swallowing problems occur after a specific jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Researchers will measure nasal speech, swallowing ability, and voice changes in 28 adults before and after surgery. The goa…

This early-phase trial studies how the antifungal drug fluconazole changes the gut microbiome and immune system in 50 healthy men aged 18-35. Participants take one 200 mg tablet daily for 14 days or receive no treatment. Researchers compare stool and blood samples over 6 months t…

This study tests whether a daily capsule of pasteurized Akkermansia muciniphila (a food supplement) can safely help adults recover after being in the ICU for sepsis. Fifty participants will take either the supplement or a placebo for 56 days. Researchers will check stool and bloo…

This study tests a new way for people to share their health data from wearables like smartwatches to help improve heart disease prevention. Researchers want to see if this approach can include groups often left out of research, such as women and people with lower incomes. About 4…

This study looks at how the immune system of children with hemophilia A stays tolerant to the missing clotting protein (FVIII) when they use newer non-factor therapies. Researchers will follow 500 children under 18 for several years, taking blood and stool samples to understand w…

This study aims to find biological markers (biomarkers) in the blood that can help doctors quickly identify transfusion-related acute lung injury (TRALI) in intensive care patients. TRALI is a rare but dangerous complication of blood transfusions, especially in critically ill peo…

This study looks at whether a standard way to measure pressure in the heart's left chamber (using a balloon-tipped catheter) gives the same results as the most accurate method (directly measuring pressure in the left atrium). The researchers will study 136 adults having heart sur…