Academisch Medisch Centrum - Universiteit Van Amsterdam (amc-uva)

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic gut condition causing inflammation and discomfort. 85 adults received four treatments through a tube and enema. The goal was to see if donor stool could reduce sym…

This study looked at 410 people with a bile duct infection (cholangitis) who had successful drainage of the bile duct. It compared a very short course of antibiotics (1 day) to the usual longer course (4 to 7 days) to see if the short course was just as good at curing the infecti…

This study tested a personalized breathing machine approach during open abdominal surgery to prevent lung complications like pneumonia or respiratory failure. Over 1,400 patients at high risk for lung problems took part. The key idea was to adjust the machine to avoid high pressu…

This study tested whether implanting a heart defibrillator under the skin (S-ICD) without doing a defibrillation test is as safe and effective as doing the test. Nearly 1,000 adults at risk of dangerous heart rhythms took part. The goal was to see if skipping the test still allow…

This study tested whether custom-made shoes and other foot devices, tailored to each person's needs, could reduce the return of foot ulcers in people with diabetes. 126 adults with diabetes and a history of foot ulcers were followed for a year. The goal was to see if this persona…

This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and fibrosis. Thirty adults with biopsy-confirmed liver scarring took part in a 21-week randomized, double-blind trial…

This study tested whether giving sickle cell patients two drugs (azathioprine and hydroxyurea) for three months before a stem cell transplant could help the transplant work better. Twenty adults with a matched sibling donor took part. The goal was to see if this approach could re…

This study combined data from nearly 4,000 stroke patients to see how often a heart CT scan finds blood clots that standard ultrasound might miss. Researchers looked at how well this quick scan, done during the initial stroke workup, detects clot sources in the heart. The goal is…

This study tested a special plastic stent with a retrieval string to drain bile from the liver in 40 people with bile duct cancer that could be removed by surgery. The goal was to see if the stent could safely reduce bile buildup before the operation. The approach focuses on impr…

This small pilot study tested whether a single ketone drink could improve brain function in 28 adults with schizophrenia or bipolar disorder. Participants drank either a ketone drink or a sugary control drink, then had brain wave tests, thinking tasks, and blood draws. The study …

This study tested whether humans can develop immunity to tick bites by repeatedly exposing 11 volunteers to uninfected ticks. Researchers measured tick feeding, molting, and survival, along with signs of immune response like itching and redness. The goal is to lay groundwork for …

This study tested a new way of helping patients breathe during a procedure that destroys liver tumors with heat or electricity. The new method, called flow-controlled ventilation, keeps the diaphragm more still than standard methods, which could help doctors place needles more ac…

This study tested a new technique to collect larger pieces of tissue from the duodenum (the first part of the small intestine) during a routine endoscopy. Researchers wanted to see if these bigger samples could be processed more effectively for lab tests, including single-cell an…

This study brought together 35 healthcare experts from around the world to agree on the best ways to clear mucus from the airways of critically ill patients who are on breathing machines. The goal was to create a shared set of recommendations for treatments like humidification, i…

This study looked at how the antibiotic ceftriaxone behaves in the blood and belly fluid of 20 adults with liver cirrhosis and ascites (fluid buildup). Participants were already receiving ceftriaxone for infection prevention or treatment. Researchers collected leftover blood and …

This completed study followed over 1,100 adults in the Netherlands who received monoclonal antibodies or antiviral pills for COVID-19. Researchers collected blood samples and nasal swabs over 90 days to track how the virus and the body's immune response changed during treatment. …

This study looked at how long it takes for a key stress hormone (cortisol) and its carrier protein to return to normal after healthy women stop taking combined oral contraceptive pills. Twenty-four women were followed for several weeks after stopping the pill. The goal was to und…

This study tested whether an automated device called FlowSure can measure urine output more accurately than the usual manual method in hospital patients with a urinary catheter. 75 adults took part, and their urine was monitored over 8- and 24-hour periods. The goal was to see if…

This worldwide study looked at how fluids and blood pressure medicines are given to critically ill patients who need a breathing machine. Researchers collected data from over 2,500 patients in intensive care units to understand current practices and how they relate to patient out…

This study looked at the brain's central clock in 28 people with different stages of insulin resistance, including those with type 2 diabetes. Using advanced MRI scans, researchers measured how the brain clock responds to light. The goal was to understand if a disrupted brain clo…