COVID19

This early-stage trial tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The vaccine uses a virus-like particle to train the immune system, and some doses included an adjuvant to boost response. The main goals were to check safety and m…

This study looked at how well the Pfizer mRNA vaccine triggers an immune response in people with weakened immune systems compared to healthy individuals. About 539 adults received two doses of the vaccine, and researchers measured antibody levels and side effects. The goal was to…

This study tests an experimental drug called SPI-1005 (ebselen) in adults hospitalized with severe COVID-19. Participants receive either the drug or a placebo to see if the drug is safe and helps improve recovery. The trial is randomized and double-blind, meaning neither patients…

This study looked at whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help critically ill patients fight the virus. The plan was to collect plasma from up to 240 recovered donors and give it to sick patients. However, the plasma donat…

This study tested whether giving plasma from people who recovered from COVID-19 to those with severe or critical COVID-19 is safe and helps them get better. 350 adults received the plasma treatment. The main goals were to track serious side effects and see if fewer people died wi…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness and long COVID in 1,323 adults with early COVID-19. Participants were overweight or obese and not hospitalized. The key finding was that metformin reduced the risk of …

This early study tested whether over-the-counter mouthwash could lower the amount of SARS-CoV-2 virus people breathe out. 34 adults with recent COVID-19 used mouthwash or water, and researchers measured virus in their breath and saliva before and after rinsing. The goal was to se…

This Phase 2 trial tested whether combining famotidine (Pepcid) and celecoxib (Celebrex) could help people with COVID-19 recover faster. Only 4 participants were enrolled, making it too small to draw firm conclusions. The study aimed to see if these drugs could reduce symptom sev…

This study tested whether using very small breaths (ultraprotective ventilation) on a breathing machine, without a heart-lung bypass machine, could improve survival and reduce time on the ventilator for COVID-19 patients with severe lung injury. About 220 adults with confirmed CO…

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe. 185 patients were randomly assigned to receive one of the drugs or standa…

This study looked at whether giving nebulised heparin (a blood thinner delivered as a mist) to COVID-19 patients on mechanical ventilation could help them get off the breathing machine sooner and reduce deaths. The trial combined data from several smaller studies in Australia, Ir…

This study tested two drugs—remdesivir and aviptadil—in hospitalized COVID-19 patients with severe breathing failure. About 473 participants received either a study drug plus standard care or a placebo plus standard care. The goal was to see if these drugs could safely improve ou…

This completed Phase 3 trial tested the safety and effectiveness of remdesivir in 87 hospitalized COVID-19 patients with acute respiratory distress syndrome (severe breathing failure). Participants received either remdesivir plus standard care or a placebo plus standard care for …

This phase 3 trial tested whether the drug aviptadil can help hospitalized COVID-19 patients with acute respiratory distress syndrome (ARDS). 471 participants received either aviptadil plus standard care or a placebo plus standard care. The main goal was to see how well patients …

This study looked at whether giving hospitalized COVID-19 patients two doses of plasma from people who had recovered from COVID-19, on top of standard care, helps them recover faster. 55 adults with pneumonia or low oxygen levels took part. The main goal was to see if this treatm…

This completed trial tested whether natural supplements like omega-3, black seed oil, Indian costus, and quinine could boost the immune system of 150 COVID-19 patients. Participants had mild to moderate symptoms and were monitored for recovery time, fever, lung inflammation, and …

This completed Phase 4 trial tested a herbal supplement called AntiCov-220 in 82 people with underlying health conditions, including HIV and cancer. The goal was to see if it could prevent and treat COVID-19 by boosting the immune system and fighting the virus. The study compared…

This study tested whether filtering the blood (therapeutic plasma exchange) could help severe COVID-19 patients by removing harmful immune molecules that cause lung damage. Twenty-one adults in intensive care with COVID-19 and lung failure were randomly assigned to receive either…

This study collected nasal swabs, throat swabs, and saliva samples from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a point-of-care device called LumiraDx, which aims to quickly and accurately detect these viruses. The study focused on…

This study checks whether a fingerstick blood test for COVID-19 antibodies gives the same results as standard lab tests using blood from a vein. About 42 people who recently had a positive COVID-19 PCR test will provide both fingerstick and venous blood samples. The goal is to se…

This study tested a quick COVID-19 antigen test called LumiraDx at various point-of-care sites, like clinics. Over 1,100 people with COVID-19 symptoms took part. The test's accuracy was compared to standard lab methods to see how well it detects the virus.

This study by Mayo Clinic tested whether analyzing chemicals in a person's breath could help diagnose or predict the course of liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants and looked for unique patterns of volatile organic c…

This completed study looked at how well two different blood tests could detect antibodies against the virus that causes COVID-19. Researchers followed 829 adults who had tested positive for COVID-19, checking their blood during hospitalization and for up to 12 months afterward. T…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This study tested whether using box fans with special filters and improving home ventilation could lower the chance of COVID-19 spreading from one infected person to others living in the same home. Researchers studied 214 people living in households with at least 3 members. The g…

This study tested two practical methods to increase COVID-19 vaccination among over 65,000 patients at Utah community health centers. One group received text message reminders to get vaccinated, while another group got texts plus a personal navigator to help with logistics like s…

This study looked at whether testing people for COVID-19 just before a large indoor concert could keep the event from causing new infections. Over 6,600 healthy adults aged 18-45 either attended the concert after a negative test or stayed home. The goal was to see if the concert …

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested a 6-week program called Heart Up! that uses text messages and social support to help adults with heart disease become more physically active and feel less hopeless. About 224 patients who had a heart attack or related procedure took part. The program aimed to im…

This study tested whether adding functional electrical stimulation (FES) to cycling exercises helps people who survived severe COVID-19 recover more quickly. Twenty-two patients who had been on ventilators in the ICU took part in a 4-week rehab program. Half did cycling with FES,…

This study tested whether common medications, originally made for other illnesses, could help adults aged 30 and older recover faster from mild to moderate COVID-19 without needing hospital care. Over 3,200 participants took either a study drug or a placebo and reported their sym…

This large study tested whether common medications like ivermectin and fluvoxamine can help ease mild-to-moderate COVID-19 symptoms in adults who are not hospitalized. Over 10,000 participants took either the study drug or a placebo and reported their symptoms remotely. The goal …

This study tested a 30-week walking program for cancer survivors who had been hospitalized with COVID-19. The goal was to see if the exercise was safe and caused few side effects. Only 3 people took part, so the results are very early and not conclusive.

This study tested whether motion-controlled video games in virtual reality could help people with long COVID feel better. 79 participants either played VR games or did standard exercises. Researchers measured pain, fatigue, mood, and quality of life to see if the VR approach was …

This study tested a 21-herb formula called modified Qing Fei Pai Du Tang (mQFPD) in 60 adults with mild-to-moderate COVID-19. Participants took either the herb capsules or a placebo for 14 days. The main goal was to see if the formula is safe and feasible to use, not yet to prove…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom testing. The goal was to see which approach reduced COVID-…

This study tested whether community health workers with lived experience of incarceration could help people recently released from jail or prison get COVID-19 tests and adopt safety measures like mask-wearing and social distancing. The program included education, on-site testing,…

This study followed 380 people who had COVID-19 pneumonia for one year after they left the hospital. Researchers used heart ultrasounds, lab tests, and CT scans to check for heart problems. The goal was to understand how COVID-19 affects the heart over time.

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study followed 610 adults who had heart surgery to see how often they develop postoperative delirium—a sudden state of confusion that can come and go. Researchers collected information on known risk factors like age, high blood pressure, and diabetes, and tracked outcomes su…

This study looked at whether having COVID-19 makes people more likely to develop a pulmonary embolism (a blood clot in the lungs). Researchers reviewed medical records of 347 patients who had a CT scan of their lungs. They compared those who tested positive for COVID-19 with thos…

This completed study looked at lung function in 42 people recovering from COVID-19. Participants inhaled a special form of xenon gas that shows up on MRI scans, allowing researchers to see how well different parts of the lungs were working. The goal was to understand how mild, mo…

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This study looked at how the thymus gland, which produces immune cells called T cells, might influence COVID-19 severity. Researchers compared 85 hospitalized patients with and without COVID-19 to see if genetic differences in thymus function were linked to worse lung damage. The…

This completed study looked at how a COVID-19 infection during pregnancy, along with related stress, might affect a baby's brain development. Researchers followed 62 mothers and their infants, using surveys, brain scans (MRI and EEG), and developmental tests. The goal is to bette…

This study examined how people with mild or no COVID-19 symptoms respond to the virus. Researchers measured immune markers in the blood of 57 adults who tested positive. The goal was to understand why some people clear the virus quickly while others develop severe illness.

This study looked at how the COVID-19 pandemic changed the way people with multiple sclerosis (MS) reported and managed their relapses. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April–June 2020) with those who had a relapse during t…

This study used advanced total-body PET scans to look at how COVID-19 affects the lungs' blood-air barrier. Thirteen adults who had COVID-19 and healthy volunteers each had two scans, one at the start and one four months later. The goal was to measure changes in lung function ove…

This completed study followed 200 adults who had COVID-19 to see if the virus causes long-term heart problems or mental health issues. Participants wore health-tracking devices and answered surveys about anxiety, depression, and substance use. The goal was to better understand th…

This study looked at the best ways to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find what messages and strategies work best to k…

This completed study looked at 355 adults with Long COVID in Suffolk and North Essex to understand their symptoms and rehabilitation needs up to 36 months after infection. The goal was to better diagnose and manage the condition, focusing on helping people return to everyday acti…

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies from infection or vaccination. Researchers followed 152 adults and children with CF for two years, taking blood samples every six months. They aimed to understand how many had antibodies, how l…

This completed study looked at 543 people who survived severe COVID-19 with lung failure (ARDS) to see if their socioeconomic status affected their recovery. Researchers checked breathing, mental health, and quality of life six months after leaving the ICU. The goal is to use thi…

This study compared two methods to increase COVID-19 testing among patients at Utah community health centers: text message reminders alone versus text messages plus a patient navigator who helped with logistics. Over 44,000 English- or Spanish-speaking adults with a working cell …

This study followed 113 people with cystic fibrosis (CF) over two years to see how many developed antibodies against COVID-19, either from infection or vaccination. Researchers collected blood samples and health data to understand if CF patients have a lower infection rate and ho…

This completed study looked at 25 people who had COVID-19 but were not hospitalized, yet still felt short of breath and tired. Researchers measured their diaphragm strength using advanced breathing tests and ultrasound. The goal was to see if diaphragm weakness is a hidden cause …

This completed study looked at breathing muscle function in 50 people who were hospitalized for COVID-19. Half had been on a ventilator, half only needed extra oxygen. Researchers used advanced tests to measure diaphragm strength and movement. The goal was to understand why many …

This study followed 214 people who tested positive for COVID-19. Participants received daily text messages asking about their symptoms, like fever, cough, and loss of taste or smell. The goal was to learn how symptoms develop and vary throughout the day, helping researchers bette…

This study monitored 219 adults with severe COVID-19 who needed a ventilator for at least 72 hours. Researchers checked for serious fungal infections, especially aspergillosis, using standard diagnostic methods. The goal was to learn how common these infections are and what puts …

This study looked at eye problems in 23 COVID-19 patients in intensive care. Doctors checked for damage to the cornea, retina, and optic nerve at several time points. The goal was to find and treat eye issues early to prevent vision loss.

This study asked 714 breast cancer survivors about their experiences with the COVID-19 vaccine. Researchers wanted to understand if lymph node swelling—a common vaccine side effect—caused worry or raised the risk of lymphedema (arm swelling) in these patients. The study collected…

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very ill pat…

This study looked at eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used many eye exams and scans to find problems like inflammation, dry eye, and blood vessel damage. The goal was to better understand what eye issues can happen after a serious COV…

This study followed 187 people who had COVID-19 to see how their antibody levels changed over 24 months. Researchers took blood samples and, in some cases, nasal swabs to measure both general and neutralizing antibodies. They also looked at how the severity of the initial infecti…

This study examined whether strict COVID-19 rules in nursing homes (like banning visitors and confining residents) saved lives or caused harm. Researchers tracked over 12,000 residents for one year, comparing death rates in homes that followed guidelines closely versus those that…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers used molecular tests to find active infections and blood tests to check for past infections and immunity. The goal was to understand infection rates, incl…

This study looked at the psychological impact of the COVID-19 pandemic on healthcare workers in intensive care units. Over 700 doctors, nurses, and aides completed questionnaires about post-traumatic stress, anxiety, depression, and burnout. The goal was to measure how common the…

This completed study followed 105 pregnant women who had COVID-19 or received a COVID-19 vaccine. Researchers measured antibodies in the mothers' blood and breast milk, as well as in the umbilical cord blood at delivery, to see how immunity transfers to the baby. The goal was to …

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This completed study looked at whether the COVID-19 vaccine triggers a strong immune response in 146 people with multiple myeloma or Waldenstrom's macroglobulinemia. Researchers measured antibody levels 28 days after the final vaccine dose. The goal was to see if these patients, …

This completed study enrolled over 1,000 people in the Dominican Republic to track how COVID-19 spreads and how to control it. Researchers provided some households with alcohol-based hand sanitizer and monitored handwashing habits, virus exposure, and vaccine attitudes. The goal …

This completed study followed 332 adults who were hospitalized with severe COVID-19 pneumonia and needed oxygen. Researchers used CT scans and breathing tests to check for lasting lung damage. The goal was to understand how the lungs recover after a serious infection.

This completed study followed 6,000 adults who had COVID-19 symptoms and were tested for the virus. Participants completed online surveys every 3 months for 18 months to track long-term health issues like fatigue, brain fog, and heart problems. The goal was to better understand t…

This completed study looked at why placing patients with severe lung failure (ARDS) on their stomachs (prone positioning) improves oxygen levels. Researchers used lung ultrasound to measure changes in 60 patients, including those with COVID-19. The goal was to understand who resp…

This study looked at how a mix of home and on-site resistance training affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, obstructive sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 completed 18 exercise sessions. Researchers …

This completed study looked at how the COVID-19 pandemic affected online gambling in France and Sweden, using data from 120,000 gamblers. Researchers compared gambling behaviors before and during the pandemic, including money spent and types of games played. They also examined di…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their mobility and daily function changed over time. Researchers measured physical abilities like walking, balance, and thinking skills. The goal is to understand recovery patterns so doctors can …

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…

This completed study followed 85 COVID-19 survivors who needed a breathing machine in the ICU. Researchers tracked their physical, thinking, and emotional recovery from the hospital until they returned home. They compared walking patterns to healthy people to understand the chall…

This completed study followed 1,366 adults in Luxembourg who tested positive for COVID-19. Researchers tracked symptoms and took blood, swab, and stool samples to identify factors linked to severe disease. The goal was to better predict patient outcomes and improve care.

This completed study followed 300 adults who had mild to moderate COVID-19 but were not hospitalized. Researchers tracked their symptoms for up to a year to see how long it took to fully recover and how lingering symptoms affected daily life. The goal was to better understand lon…

This completed study tested nearly 2,800 primary care health workers (like doctors, pharmacists, and dentists) and their household members in France for COVID-19 antibodies. The goal was to find out how many had been exposed to the virus and to understand risk factors. Participan…