COVID19

This early-stage study tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The goal was to check the vaccine's safety and see how well it triggers the immune system. Researchers gave two doses, with or without an immune booster (adjuvant)…

This study tested two ways to help more people get the COVID-19 vaccine: sending text reminders, and offering a patient navigator to help with logistics like appointments and transportation. Over 65,000 adults from Utah community health centers took part. The goal was to see whic…

This study tested a blood-filtering treatment called plasma exchange in 21 adults with severe COVID-19 and breathing problems. The goal was to remove harmful inflammatory substances from the blood to improve lung function and reduce the need for a breathing tube. Researchers comp…

This study tested whether the drug aviptadil, added to usual care, helps hospitalized COVID-19 patients with severe breathing failure recover better than a placebo. 471 adults took part, and researchers tracked their recovery and safety over 90 days. The goal was to see if avipta…

This study tested two anti-inflammatory drugs, ruxolitinib and fostamatinib, in 185 hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the pneumonia from becoming severe, which would require a ventilator or cause death. …

This study looked at different treatments to help the immune system fight COVID-19. It included 150 patients with mild to moderate symptoms. Researchers measured recovery time, fever, lung inflammation, and other health markers to see which treatments worked best.

This early study tested whether common mouthwashes can reduce the amount of SARS-CoV-2 virus that people with COVID-19 breathe out. 34 adults with a recent positive test provided breath samples using a face mask before and after rinsing with mouthwash or water. Researchers measur…

This study tested whether the drug remdesivir helps hospitalized COVID-19 patients with severe breathing problems recover better than standard care alone. About 87 adults took part, receiving either remdesivir or a placebo plus usual treatments. The main goal was to see how well …

This study tested a new way of using breathing machines in 220 adults with severe COVID-19 lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. Participants were randoml…

This study looked at whether giving inhaled heparin to COVID-19 patients on ventilators could help them get off the breathing machine sooner and lower the risk of death. Researchers combined data from several smaller trials in Australia, Ireland, the US, and the UK. A total of 57…

This study tested a herbal supplement called AntiCov-220 in 82 people with health problems like HIV, hepatitis, or cancer to see if it could prevent or treat COVID-19. The supplement contains plant extracts and vitamins designed to boost the immune system and fight the virus. The…

This study looked at whether giving hospitalized COVID-19 patients two doses of plasma from people who had recovered from COVID-19, on top of standard care, helps them recover faster. 55 adults with pneumonia or low oxygen levels took part. The main goal was to see if this treatm…

This completed Phase 2 trial tested combinations of drugs in people with COVID-19. Only 4 people took part. The goal was to see if the drugs helped patients recover faster and lower the risk of death. The study used a flexible master protocol to guide both hospital and home treat…

This large, international study aimed to find safe and effective treatments for people hospitalized with COVID-19 who developed severe breathing failure. It tested several investigational drugs, including aviptadil and remdesivir, by adding them to the standard hospital care pati…

This study tested whether using box fans with special filters and improving home ventilation could stop COVID-19 from spreading to other family members. Researchers followed 214 people living in shared homes. They measured who got sick and checked air quality to see if the change…

This study tested whether screening people for COVID-19 just before a large indoor concert could prevent the virus from spreading. Over 6,600 healthy adults either attended the concert after a negative test or stayed home. The goal was to see if the concert group had the same low…

This study aimed to find the best way to encourage more people to get tested for COVID-19 at Utah's community health centers. Researchers compared two methods: sending automated text messages, and combining texts with personal support from a 'patient navigator' to help with sched…

This early-phase study tested whether a 30-week home walking program is safe for cancer survivors who were hospitalized for COVID-19. Only 3 people took part. The goal was to see if the exercise caused few or mild side effects.

This study tested three remote programs to help people with depression and substance use caused by COVID-19 stress. 113 adults from Cambridge Health Alliance took part. They either joined an 8-week online mindfulness class, an online therapy program, or received standard remote m…

This study tested whether motion-controlled video game-based virtual reality exercises can help people with long COVID feel less pain, fatigue, and improve their mood and daily life. 79 adults with long COVID symptoms for at least 8 weeks took part. The approach used fun, interac…

This study tested whether adding gentle electrical pulses to leg muscles during stationary cycling helps people who survived severe COVID-19 regain movement faster. Twenty-two adults who had been on breathing machines in the ICU took part. Researchers measured how much time they …

This study tested a 21-herb formula called modified Qing Fei Pai Du Tang (mQFPD) in 60 adults with mild-to-moderate COVID-19. The goal was to see if it is safe and feasible to use. Participants took either the herbal formula or a placebo for 14 days while self-quarantining at hom…

This large study tested whether common medications already approved for other conditions can help reduce symptoms in people with mild-to-moderate COVID-19 who are not sick enough to be hospitalized. Over 10,000 adults aged 30 and older took either a study drug or a placebo and re…

This study tested whether common medications already used for other conditions could help people with mild to moderate COVID-19 recover faster. Over 3,200 adults aged 30 and older with a positive COVID test and at least two symptoms took either a study drug or a placebo pill at h…

This study tested a 6-week program called Heart Up! that uses text messages and support from nurses and loved ones to help adults with heart disease become more physically active and feel less hopeless. About 224 patients took part. The goal was to see if extra social support cou…

This study looked at eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used special eye imaging to find problems like inflammation, blood clots, and nerve damage that could threaten vision. The goal was to better understand how COVID-19 affects the ey…

This study looked at 543 people who survived severe COVID-19 lung damage (ARDS) to see how their social and economic background affected their recovery. Researchers measured physical and mental health six months after leaving the hospital. The goal is to create personalized suppo…

This study followed 211 older adults who were hospitalized with COVID-19 to see how well they regained their ability to move, think, and do daily tasks over time. Researchers measured changes in mobility, balance, and frailty from hospital stay through recovery. The goal is to un…

This study used advanced total-body PET scans to compare lung function in 13 people who had COVID-19 with healthy individuals. Researchers measured how well the lungs' blood-air barrier worked, and followed up with COVID-19 patients 4 months later to see if any changes persisted.…

This study followed 105 pregnant women diagnosed with COVID-19 to learn how their immune systems responded and whether that protection passed to their babies. Researchers measured antibodies in mothers and newborns, and also looked at breast milk after vaccination. The goal was t…

This study looked at whether the COVID-19 vaccine triggers a strong immune response in people with multiple myeloma or Waldenstrom's macroglobulinemia. Researchers measured antibody levels 28 days after the final vaccine dose in 146 participants. The goal was to understand vaccin…

This study followed 187 people who had COVID-19 for two years to see how their antibody levels changed over time. Researchers also looked at whether the severity of the infection or other patient factors affected antibody persistence. The goal was to better understand long-term i…

This study gathered kidney tissue, blood, and urine samples from 90 adults hospitalized with COVID-19 who also had acute kidney injury. Researchers aimed to better understand how COVID-19 affects the kidneys and to identify potential treatments. Participants provided samples duri…

This study looked at how long COVID-19 antibodies stay in the blood of 829 patients who had a positive COVID-19 test. Researchers used automated lab tests to check for antibodies during the hospital stay and for up to 12 months afterward. The goal was to understand the body's imm…

This study looked at why some people who were hospitalized for COVID-19 still feel tired and short of breath. Researchers measured breathing muscle strength in 50 survivors—half had been on a ventilator, half had only needed extra oxygen. The goal was to understand how severe COV…

This study followed 6,000 adults who had COVID-19 symptoms to see how their health changed over 18 months. Participants completed online surveys every 3 months. The goal was to learn about long-term problems like chronic fatigue or heart issues, not to test a treatment.

This study looked at why placing patients with severe lung failure (ARDS) on their stomachs improves breathing. Researchers used ultrasound to measure lung changes in 60 adults, including those with COVID-19. The goal was to understand who responds best to this position and why.

This study measured COVID-19 antibodies in over 2,800 primary care health workers (like doctors, dentists, and pharmacists) and their household members in France. The goal was to find out how many people had been exposed to the virus and understand their immune response. Results …

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers checked their thinking, mood, and physical abilities—like walking and breathing—as they moved from hospital to home. The goal was to understand the challenges of post…

This study looked at eye problems in 23 COVID-19 patients in intensive care. Researchers checked for damage to the cornea, retina, and optic nerve to find and treat issues early. The goal was to prevent permanent vision loss in these seriously ill patients.

This study looked at how the thymus gland, which produces immune cells called T cells, affects COVID-19 severity. Researchers examined 85 hospitalized patients to see if genetic differences in thymus function are linked to worse lung damage. The goal was to better understand why …

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies and how their bodies respond to the virus or the vaccine. Over two years, 152 adults and children with CF from European clinics gave blood samples to check for antibodies. The goal was to under…

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities in St. Louis. Over 1,300 students and staff took part. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom test…

This study looked at how having COVID-19 or feeling stressed during pregnancy might affect a baby's brain development. Researchers followed 62 mothers and their infants, measuring stress, mental health, and baby brain activity. The goal is to better understand and support familie…

This study tested whether a simple breath analysis could help diagnose or predict liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants to detect unique chemical patterns. The goal was to develop a non-invasive test for disease diagn…

This study followed 214 people who tested positive for COVID-19. Participants received daily text messages asking about their symptoms, like fever, cough, and loss of taste. The goal was to learn how symptoms change throughout the day and over the course of the illness. This was …

This study looked at how well the Comirnaty (Pfizer) COVID-19 vaccine works in people with weakened immune systems, such as those with HIV, organ transplants, or certain blood cancers, compared to healthy people. About 539 adults received two doses of the vaccine, and researchers…

This study followed 300 adults who had mild to moderate COVID-19 and were not hospitalized. Researchers called them each month for a year to see how long symptoms lasted and how they affected daily activities. The goal was to understand lingering symptoms and when people felt ful…

This study looked at how working in intensive care during the COVID-19 outbreak affected the mental health of doctors, nurses, and other caregivers. Over 700 healthcare workers answered surveys about post-traumatic stress, anxiety, depression, and burnout. The goal was to underst…

This study followed 355 adults in Suffolk and North Essex who had Long COVID for up to 36 months after infection. The goal was to understand their symptoms and how the condition affects daily life, so doctors can better diagnose and treat it. Researchers focused on a wide range o…

This study followed 1,366 people in Luxembourg who tested positive for COVID-19, tracking their symptoms and health for up to a year. The goal was to find out which factors lead to severe illness versus mild disease. Researchers collected health data and blood samples from a smal…

This study tracked 11,000 COVID-19 patients to see how often they developed dangerous blood clots in arteries or veins. Researchers looked at risk factors, treatments, and outcomes over 30 and 90 days. The goal was to better understand and prevent these complications.

This study looked at how to encourage regular COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find the best messages and strategies to keep scho…

This study enrolled 57 adults with no or mild COVID-19 symptoms to understand how their immune system responds to the virus. Researchers measured immune markers like interferons and cytokines in blood samples. The goal was to see if these patients can clear the virus quickly, unl…

This study looked at 32 adults in the ICU on ECMO (a heart-lung machine) who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole moved through their bodies to find the best dose. The …

This study looked at 332 adults who had severe COVID-19 pneumonia and needed oxygen in the hospital. Researchers used CT scans and breathing tests to check for lasting lung damage three months after discharge. The goal was to understand how often and how severe these respiratory …

This study looked at how the COVID-19 pandemic affected the mental health of nursing home staff in Occitanie, France. Over 500 workers answered surveys about post-traumatic stress, depression, and burnout. The goal was to understand how common these problems were during the healt…

This study surveyed 714 breast cancer survivors to understand their experiences with COVID-19 vaccination, focusing on lymph node swelling. Researchers wanted to know if this common vaccine side effect causes extra worry or risk of lymphedema in patients who had lymph node surger…

This study followed 200 adults who had COVID-19 to see if the virus causes long-term heart problems or mental health changes. Participants wore health trackers and completed surveys about anxiety, depression, and substance use. The goal was to learn more about recovery, not to te…

This study looked at how COVID-19 spread in four hospitals in Bamako, Mali. Researchers tested 450 patients and healthcare workers for the virus and checked their immunity. They also tested a fast, portable molecular test and studied virus changes over time. The goal was to bette…

This study looked at over 12,000 nursing home residents to see how well COVID-19 prevention measures (like visitor restrictions and isolating sick residents) worked. Researchers wanted to know if these steps lowered deaths from COVID-19 but also if they might have increased death…

This study looked at how a mix of home and in-person exercise sessions affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 participated in 18 tailored exercise sessions. The goal …

This study followed over 1,000 people in the Dominican Republic to understand how COVID-19 spreads and how to control it. Researchers tracked symptoms, tested for antibodies, and checked handwashing habits. The goal was to learn more about the virus and find better ways to preven…

This study tracked 219 adults with severe COVID-19 who needed a ventilator to breathe. Researchers wanted to see how many also developed serious fungal infections, especially a lung infection called aspergillosis. They used standard tests to check for fungi, but did not give any …

This study followed 113 people with cystic fibrosis (CF) for two years to see how many developed COVID-19 antibodies from infection or vaccination. Researchers collected blood samples and health data to understand if CF patients have different immune responses or milder COVID-19 …

This study looked at how the COVID-19 pandemic changed the way multiple sclerosis (MS) relapses were reported and managed. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April-June 2020) to those who had a relapse during the same months …

This study tested whether adding a rapid TB test (Xpert Ultra) to standard care helps find tuberculosis earlier in young children hospitalized with severe pneumonia. Over 2,500 children aged 2 to 59 months from six high-TB-burden countries took part. The goal was to see if early …

This study looked at how the COVID-19 pandemic affected online gambling in France and Sweden. Researchers analyzed data from 120,000 gamblers to see if lockdowns and stress led to more gambling. The goal was to understand changes in gambling habits and identify groups at risk for…

This study looked at whether weakness in the diaphragm, a key breathing muscle, causes ongoing shortness of breath and fatigue in people who had COVID-19 but were not hospitalized. Researchers measured breathing muscle strength and used ultrasound to check diaphragm function in 2…