COLORECTAL ADENOCARCINOMA

This early-phase trial is testing a new radioactive drug that seeks out a protein called Nectin-4 found on many cancer cells. The drug delivers a dose of radiation directly to the tumor, aiming to destroy it while sparing healthy tissue. About 150 adults with advanced bladder, br…

This early-stage study tests whether combining two drugs (sacituzumab govitecan and capecitabine) is safe for people with advanced gastrointestinal cancers that have stopped responding to standard treatments. About 20 adults with stomach, colorectal, or pancreatic cancer will tak…

This early-stage trial tests a new drug (CHS-114) combined with an immunotherapy (toripalimab) in 154 people with advanced or metastatic solid tumors. The goal is to see if the combination is safe and can shrink tumors. Participants must have at least one measurable tumor and be …

This early-stage study tests a new treatment using a patient's own immune cells, engineered to recognize and attack cancer cells with a specific KRAS mutation (G12D). It is for adults with advanced solid tumors like lung, colorectal, pancreatic, or endometrial cancer that have no…

This study tests whether two drugs, fruquintinib and tislelizumab, can control leftover cancer cells in people with colorectal cancer who have completed chemotherapy but still show signs of minimal residual disease (MRD) on a blood test. About 20 adults with stable disease will r…

This study tests a new drug called BNT329 in people with advanced solid tumors that have a specific marker (CA19-9). The main goals are to check safety and find the best dose. About 245 participants will take part. The drug works by targeting cancer cells and may help control tum…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, or breast cancer) that have not responded to other therapies. The treatment uses specially engineered immune cells designed to kill cancer cells while leaving healthy cell…

This study tests whether the antibiotic metronidazole can lower the amount of a specific bacteria (Fusobacterium nucleatum) in colorectal cancer tumors. About 40 adults with untreated colorectal cancer will take metronidazole before surgery. Researchers will compare bacteria leve…

This early-phase trial tests a two-step vaccine strategy in adults with advanced colorectal or small bowel cancer that has stopped responding to standard treatments. Participants first receive one vaccine injection, followed by two doses of a second vaccine four weeks apart. The …

This study tests whether combining the targeted drug cabozantinib with immunotherapy drugs (durvalumab, with or without tremelimumab) is safe and effective for people with advanced stomach, esophageal, liver, or colorectal cancer. About 117 adults with stage 3 or 4 disease that c…

This early-phase study tests a new drug, CLSP-1025, designed to attack cancer cells that have a specific change in the p53 gene (called R175H). The study enrolls adults with advanced solid tumors (like lung, colon, or breast cancer) that have this mutation and a specific immune t…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This study tests a combination of three drugs (trastuzumab-deruxtecan, capecitabine, and bevacizumab) as a first treatment for people with HER-2 positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see how well the drugs shrink tumors. About …

This study tests a new nanovaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer patients who have had surgery and chemotherapy but are at high risk of their cancer coming back. The vaccine is designed to train the immune system to …

This study looks at whether drinking instant coffee every day for 6 weeks can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 adults who completed surgery, chemo, or radiation at least 2 months ago will par…

This early-stage study is testing an experimental oral drug, VVD-133214, in people with advanced solid tumors that have specific genetic features (MSI or dMMR). The drug works by blocking a protein that helps these cancers grow. The study will check safety and how well the drug w…

This early-stage trial tests a new drug called INBRX-109 in people with advanced solid tumors, including Ewing sarcoma and colorectal cancer. The drug is designed to attach to a protein on cancer cells and trigger their death. The main goals are to check safety and see if the dru…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This phase 3 study compares a new drug, AK112, combined with chemotherapy against the standard treatment (bevacizumab plus chemo) for people with metastatic colorectal cancer that has not been treated before. The goal is to see if the new combination helps patients live longer wi…

This study is testing a new blood test called DENEB that looks for tiny genetic markers (microRNAs) to detect colorectal cancer and precancerous polyps early. Researchers will collect blood samples from 2,000 people who are also getting a colonoscopy, then compare the test's accu…

This study tests a special dye and imaging system to help surgeons see colorectal, pancreatic, esophageal, and stomach cancers during surgery. About 66 adults scheduled for cancer surgery will receive the dye, and the imaging system will check if it lights up cancer tissue. The g…

This study is developing a blood test that uses tiny particles called exosomes and artificial intelligence to find colorectal cancer in people under 50. The goal is to catch the disease early without needing a colonoscopy. Researchers will test blood samples from 400 participants…

This study is testing a new blood test that measures a protein called MMP14 to see if it can better detect colorectal cancer or precancerous growths. Researchers will enroll 650 people aged 50-74 who already need a colonoscopy after a positive stool test. The goal is to find a cu…

This study tests a new microwave-based device, called MiWEndo, that is used during a standard colonoscopy to help doctors find polyps in the colon. About 50 people who already have a polyp in their rectum will take part. The goal is to see if the device is safe and can find more …

This study tests a daily injection called TCMCB07 in 120 people with newly diagnosed colorectal cancer who are starting chemotherapy. The goal is to see if it can help maintain body weight and muscle mass, which often drop during treatment. Participants will receive either the st…

This study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…

This study looks at how chemotherapy and radiation affect the reproductive and sexual health of young adults with early onset colorectal cancer. Researchers will track hormone levels and fertility over time in 120 men and women. The goal is to better understand the long-term effe…

This study is testing if a simple blood test can find tiny bits of tumor DNA left after treatment, which might help doctors know if colorectal cancer will return sooner than current methods. About 1,000 people with colorectal cancer who have finished or are about to start treatme…

This study watches 40 adults with colorectal cancer who have no visible tumors but still have cancer DNA in their blood (minimal residual disease). Researchers will see how well biomarker-directed therapy, chosen by their own doctor, works to clear that DNA. The goal is to learn …

This study tests whether artificial intelligence can predict serious complications after colorectal cancer surgery by analyzing CT scans, MRI, and tissue images. Researchers will look back at data from 750 past patients and also study 210 future patients. The goal is to see if AI…

This study looks at whether a blood test that finds tiny bits of tumor DNA can better predict if colorectal cancer will return after surgery than the usual method of examining the removed tumor. About 1,600 people with stage I-III colorectal cancer will give blood samples after s…

This study is testing a new lab test that helps doctors choose the most effective chemotherapy drugs for each patient. It involves 20 people with advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The test analyzes a small tissue sample to see wh…

This early-stage trial is testing whether fluoxetine (Prozac), a common antidepressant, can alter immune cells inside colorectal tumors. Ten adults with untreated colorectal cancer will take fluoxetine before surgery. Researchers will compare tumor samples taken before and after …