Smart immune cells take aim at Hard-to-Treat cancers
NCT ID NCT06682793
First seen Oct 31, 2025 · Last updated Jun 17, 2026 · Updated 29 times
Summary
This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, or breast cancer) that have not responded to other therapies. The treatment uses specially engineered immune cells designed to kill cancer cells while leaving healthy cells alone. The study has two parts: first, finding a safe dose, and second, checking if that dose shrinks tumors. About 240 people will take part.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Banner MD Anderson Cancer Center
RECRUITINGGilbert, Arizona, 85234, United States
Contact Email: •••••@•••••
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Fred Hutch Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
Contact
Contact Email: •••••@•••••
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Mayo Clinic
RECRUITINGJacksonville, Florida, 32224, United States
Contact Phone: •••-•••-••••
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-••••
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33606, United States
Contact Email: •••••@•••••
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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The Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
Contact Email: •••••@•••••
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UCLA Medical Center
RECRUITINGLos Angeles, California, 90404, United States
Contact
Contact Email: •••••@•••••
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UCSD Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
Contact
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Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.