CEREBRAL PALSY

This trial compares two rehabilitation techniques—constraint-induced movement therapy (CIMT) and proprioceptive neuromuscular facilitation (PNF)—to see which better improves hand dexterity in children with cerebral palsy. The study includes children aged 8 to 13 with moderate men…

This study tests whether a smart ankle-foot orthosis (a brace that gives feedback on walking) can improve mobility in 60 children with cerebral palsy. Some participants can also choose to receive a single injection of 5-Azacitidine, a drug used in cancer, to see if it boosts the …

This study tests whether a 16-week program of spinal stimulation (using electrodes on the skin) combined with walking or activity training can improve movement in children with cerebral palsy. Some participants can also choose to receive a single injection of a drug called 5-Azac…

This study looks at whether giving iron supplements to children with low iron before hip surgery can reduce their need for blood transfusions and improve recovery. The trial includes 180 children aged 0-18 who are scheduled for a specific type of hip surgery, many of whom have ce…

This study tests whether starting a personalized home therapy program early (before age 2) can improve motor skills in babies at high risk for cerebral palsy. Researchers will compare children who receive this early program with those who get standard care. The goal is to see if …

This study tests whether injecting a child's own bone marrow cells into the spine, combined with rehabilitation, can improve motor function in children with cerebral palsy from birth injuries. Sixty children aged 1 to 6 years will be randomly assigned to receive either the cell t…

This study tests whether a virtual version of the Abecedarian Approach, an early childhood education program, can help children ages 0-5 who had a brain injury from lack of oxygen (HIE) or were born very prematurely. Researchers will enroll 225 families and measure parent satisfa…

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

This study looks at how well a special intensive therapy called ACQUIRE Therapy works for children with motor problems caused by conditions like cerebral palsy, autism, or brain injury. The therapy involves many hours of play-based exercises each day, often with a cast or splint …

This study tests a wearable robotic exoskeleton designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device fits on the legs and can assist or resist movement during walki…

This study tests a program called Therapy Together, where caregivers lead hand therapy exercises for young children with cerebral palsy who have limited use of one hand. The program lasts 8 weeks and aims to improve hand function and daily skills. Researchers will compare these c…

This study is testing a new, non-invasive respiratory sensor (pneuRIP) to detect lung problems in 250 children with severe cerebral palsy. The goal is to see if the sensor can screen for issues like pneumonia or airway blockage, and to understand how lung function relates to spin…

This study tests whether giving magnesium sulphate to pregnant women at high risk of preterm birth can protect their babies from cerebral palsy. About 138 women between 32 and 35 weeks of pregnancy will receive either magnesium or a placebo before delivery. Researchers will then …

This study tests a therapy called HABIT-ILE, which uses structured hand and leg exercises, to see if it can improve both motor skills and cognitive functions like memory and attention in children with spastic cerebral palsy. 42 children will receive 90 hours of therapy and be com…

This pilot study tests whether a 10-week treadmill training program combined with blood flow restriction (using cuffs on the legs) can safely improve walking speed in 13 children aged 8 to 18 with cerebral palsy. The children will walk on a treadmill three times a week, gradually…

This study tests whether gentle vibration on the face and neck can reduce drooling and improve muscle tone in children with cerebral palsy. Twenty children will receive either vibration plus standard therapy or a sham treatment. The goal is to see if this simple approach can ease…

This study tests whether a 24-week Frame Running training program can improve physical function, daily activity, and quality of life in children aged 8-18 with cerebral palsy or similar physical disabilities. Participants start with a low-intensity 12-week period, then move to a …

This study tests a new therapy called MOBILE to help children with cerebral palsy walk better. Fourteen children will try the therapy for 30 hours over 6 weeks. The goal is to see if the therapy is acceptable and helpful for children and families in a community setting.

This study tests whether a mild, non-invasive electrical stimulation on the back (transcutaneous spinal cord stimulation) can reduce spasticity—stiff, tight muscles—in children with cerebral palsy. Researchers will compare spinal cord activity in 30 children with CP and typically…

This study looks at whether adding whole-body vibration (standing on a vibrating platform) right before serial casting can improve ankle movement in children with cerebral palsy. About 45 kids aged 3-17 will do exercises with or without vibration before getting their weekly cast.…

This study looks at whether adding a single session of whole-body vibration to treadmill training can improve walking and reduce muscle stiffness in children with cerebral palsy. About 20 kids aged 6-17 who can walk will participate. The goal is to see if combining these therapie…

This small safety trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can safely improve hand and arm function in 10 adolescents with spastic cerebral palsy. Participants will use the device during upper limb rehabilitation sessions. The main…

This study is testing whether targeted ankle resistance training and a smart ankle assist device can improve walking in children with cerebral palsy (ages 8-21). Researchers will measure changes in walking speed, muscle activity, and endurance. The goal is to find better ways to …

This study tests whether immersive virtual reality (VR) therapy can improve cognitive, motor, and social skills in children aged 8 to 18 with ADHD, autism, or cerebral palsy. Participants will use the CAREN VR system, which provides interactive exercises with visual, sound, and t…

This study tests whether adding playful nerve-gliding activities to standard physical therapy can improve hand grip strength and dexterity in children with cerebral palsy. About 34 children aged 6-12 will be split into two groups: one gets routine therapy plus play-based hand exe…

This study looks at whether a robotic walking trainer, called Trexo, can help people with walking problems from conditions like cerebral palsy or brain injury. About 120 participants will use the robot in a hospital setting to see if it's practical and helps them reach their pers…

This study tests whether a wearable trunk brace, called the SPIO Core-Max Expedition TLSO, can improve head, trunk, and arm function in infants aged 6 to 18 months with cerebral palsy. Thirty infants will wear the brace for 2 hours daily over 6 months, and researchers will measur…

This study tests whether using a ride-on toy for 6 weeks can help children with cerebral palsy use their weaker arm and hand more. Ten children will wear a mitten on their stronger hand to encourage using the other hand while driving and playing. Researchers will measure changes …

This study tests a new approach called ENGAGE, where children with disabilities (like autism or cerebral palsy) help set their own therapy goals. About 96 kids aged 5-12 and their therapists will be split into two groups: one using ENGAGE and the other using usual therapy. Resear…

This study tests a new home-based program that uses a special treadmill and virtual reality to help children with conditions like cerebral palsy, muscle diseases, or obesity improve their walking. About 30 children aged 6 to 17 will try the program at home for at least 3 sessions…

This study tests a 10-week hand strength training program for 14 children aged 6-12 with spastic cerebral palsy. The goal is to see if it improves their grip strength and ability to manipulate objects in their hand. Researchers will measure changes using a dynamometer and the Mel…

This study tests a special therapy called Cognitive Sensory Motor Training (CSMT) to see if it can improve hand and arm function in children with cerebral palsy. The therapy combines physical tasks with mental exercises to boost coordination and sensory awareness. Researchers wil…

This study tests whether ankle braces made with 3D scanning and printing work as well as those made the old-fashioned way with plaster casts. About 50 people aged 8 and older with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury will try both types …

This study looks at whether a special therapy done at home through video calls can help infants with cerebral palsy use their weaker arm more. About 267 babies aged 4 to 13 months will be assigned to different sequences of the therapy or standard care. The goal is to see if the t…

This study aims to see if behavioral coaching, using wearable activity monitors, can help people with cerebral palsy increase their daily steps and improve mobility. Researchers will track changes in walking speed, balance, and brain activity in 32 participants. The goal is to fi…

This study tests a motor training program called 'Let's Move' for infants aged 3-8 months who are at high risk for cerebral palsy. The program involves weekly sessions alternating between clinic visits and video telehealth at home for 16 weeks. Researchers want to see if the prog…

This study tests a special neck brace designed to help children with cerebral palsy improve their head and neck control. The brace uses sensors, springs, and small motors to support and gently guide head movements during training. Researchers will enroll 30 children and measure c…

This study tests whether serious games (special video games that combine movement and thinking) can improve balance, memory, and quality of life in 30 children with cerebral palsy. Kids play daily for 30 minutes over 10 days, alongside their usual rehab. Researchers will measure …

This study uses safe brain imaging techniques (NIRS and EEG) to see how the brain controls movement in people with and without cerebral palsy. Researchers will compare brain activity patterns and test whether biofeedback training can help people with cerebral palsy improve their …

This study uses MRI scans to look at brain and spinal cord structure and function in people with cerebral palsy who experience chronic pain. Researchers hope to find patterns in the brain that are linked to pain and sensory issues. Participants aged 8 and older with cerebral pals…

This study looks at how children and young adults with cerebral palsy move, using special sensors like ultrasound, brain wave caps, and muscle stickers. Researchers want to learn more about movement to improve robotic leg braces that could help people walk better. Participants wi…

This study looks at how children with cerebral palsy (CP) adapt their walking when given feedback from a treadmill, sensors, and a wearable exoskeleton. Researchers want to understand how kids learn new movement patterns and whether training or surgery can improve their walking. …

Cerebral palsy (CP) is a brain injury that affects movement, but diagnosing it can take up to 2 years. This study follows 600 high-risk infants (premature, brain-injured, or with abnormal exams) across Irish hospitals. Researchers will use EEG sleep tests, protein markers, and co…

This study is looking at whether the brains and spinal cords of adults with cerebral palsy shrink or change over time, which might explain why some people lose function as they age. Researchers will collect and compare past and new MRI scans from 30 adults with CP across the U.S.…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study is testing whether a smartphone app can accurately measure how children with cerebral palsy move, like jumping and walking. Researchers will compare the app's results with standard motion-capture systems. The goal is to make it easier and cheaper to assess motor skills…

This study tests whether small wearable sensors (called IMUs) placed in shoes and on the body can accurately measure how children walk. Researchers will first check the sensors in healthy children aged 7–17, then in children with cerebral palsy who can walk without aids. The goal…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study examines the role of the plantaris, a small calf muscle, in children having surgery for tight ankles (equinus). Researchers will randomly change the order of tendon cuts during surgery to measure how much each contributes to ankle movement. The goal is to understand if…

This study looks at a special clinic called TLC that helps adults with conditions like cerebral palsy, spina bifida, and developmental disabilities get better, coordinated care. Many of these people face a 'cliff' when they leave children's healthcare and struggle to find adult d…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This observational study aims to understand how infants and toddlers develop thinking, language, movement, and social skills in the first few years of life. Researchers will assess 1,200 children aged 16 days to 42 months using standardized tests and parent questionnaires. The go…

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This registry collects information from up to 15,000 people with cerebral palsy in Switzerland, tracking their diagnosis, treatments, and outcomes over time. Researchers will use this data to study the condition and improve care. Participants must have a confirmed CP diagnosis an…

This research study follows the cognitive development of infants, both healthy and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, thinking, and language skills. The goal is to better understand how thes…

This study uses MRI scans of babies during natural sleep to understand how the brain develops in both healthy infants and those at risk for cerebral palsy. Researchers will follow about 200 infants from 3 months to 2 years old, using advanced imaging and motor skill tests. The go…

This study is working to create better methods for evaluating how children with and without stroke or cerebral palsy use their arms and hands. Researchers will observe 80 children, including those with perinatal stroke and typically developing infants, using video and play-based …

This study is testing whether a mobile health app system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their self-management skills and wellness. About 160 participants will use the app for one yea…

This study looks at how the brain and spinal cord work together in people with cerebral palsy compared to those without. Researchers will use brain scans and simple tasks to measure these signals. Some participants will also receive a mild electrical current over the scalp or spi…

This study aims to build a computer model that helps doctors predict developmental problems in babies diagnosed with brain injury, especially those at risk for cerebral palsy. Researchers will collect data from standard medical tests and ask parents to fill out two online questio…

This study follows 100 infants diagnosed with or at high risk for cerebral palsy from birth to age 2. Researchers will track changes in motor skills, speech, cognition, and more to understand how the condition naturally progresses. The goal is to gather knowledge that could impro…

This study aims to create and validate a Turkish version of a short neurological exam called the BRIEF-HINE for babies at high risk of brain problems. Researchers will test 120 infants aged 3 to 12 months who have conditions like premature birth or brain injury. The goal is to se…

This study follows 500 children with cerebral palsy who are having leg or spine surgery. Researchers will track their pain and opioid use for a year after surgery using surveys and sensory tests. The goal is to find out who develops chronic pain and why, so doctors can better pre…