Placenta disorder

This study tested whether giving pregnant women a balanced energy and protein supplement (BEP) can improve birth weight and reduce complications like low birth weight and preterm birth. Over 3,300 women in Bangladesh were randomly assigned to receive either BEP or standard prenat…

This trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who sur…

This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care…

This pilot study tested whether waiting 30-45 seconds before clamping the umbilical cord, instead of clamping immediately, is feasible and might improve blood health in extremely low birth weight premature infants (24-27 weeks gestation). 54 infants were enrolled. The goal was to…

This study tested whether filling the bladder with a blue dye before surgery helps surgeons avoid accidentally injuring the bladder or ureters during a cesarean hysterectomy for placenta accreta. Sixty women were randomly assigned to receive the dye or standard care. The goal was…

This study looked at whether a fast blood test (ROTEM) done during surgery for placenta accreta can help doctors decide when to give blood transfusions. 32 women took part, with half getting the rapid test and half getting standard lab tests. The goal was to see if the rapid test…

This study tested whether taking low-dose aspirin (150 mg) daily, starting in the first trimester, could reduce pregnancy complications in women with type 1 or type 2 diabetes. The trial included 137 women and looked at outcomes like preeclampsia, early preterm birth, low birth w…

This study tested a new surgical method to remove very large uteri (over 20 weeks size) during total laparoscopic hysterectomy. The technique uses a cold knife to cut the uterus into a long strip that can be pulled out through the vagina, avoiding large abdominal incisions. Twent…

This study tested whether trained community health workers visiting pregnant women at home could improve health for both mothers and children in a rural area of South Africa. The program focused on supporting women with HIV, depression, or alcohol use, and on improving child grow…

This study tested whether tranexamic acid, a drug that helps blood clot, can safely stop vaginal bleeding in pregnant women with abruptio placenta (when the placenta separates from the womb too early). 116 women at 24 weeks or more of pregnancy received either the drug or a place…

This study looked at whether giving more red blood cell transfusions (liberal strategy) to extremely low birth weight babies (under 1000 grams) helps them survive without brain damage compared to a more restrictive approach. Over 1800 infants from NICUs were followed until 22-26 …

This study tested a simple technique called cystoinflation—filling the bladder with 200 mL of saline during surgery—to see if it prevents bladder injury in women with placenta accreta spectrum (PAS). 84 women were randomly assigned to receive the bladder fill or standard surgery.…

This study looked at whether a substance in the blood called adropin can help identify placenta accreta spectrum, a serious condition where the placenta grows too deeply into the womb. Researchers measured adropin levels in 84 pregnant women—42 with the condition and 42 healthy—t…

This study tested whether a special ultrasound using contrast dye can better diagnose placenta accreta, a condition where the placenta grows too deeply into the womb and can cause severe bleeding after birth. Researchers studied 80 pregnant women at high risk for this condition. …

This study looked at whether a protein called EG-VEGF in the blood of pregnant women could predict pre-eclampsia or poor fetal growth. Researchers took blood samples and performed ultrasound scans on 142 women early in pregnancy. The goal was to see if EG-VEGF levels could serve …

This study tested whether functional MRI can detect differences in oxygen flow in the placenta and fetus between healthy pregnancies and those with intrauterine growth restriction (IUGR). Pregnant women breathed pure oxygen while MRI scans measured the BOLD effect, a signal chang…

This study tested whether taking a low-dose aspirin (160 mg) each night, starting before 16 weeks of pregnancy, could prevent pre-eclampsia and small babies in first-time mothers at high risk. Over 1,100 women with abnormal blood flow in the uterine artery were randomly assigned …

This study tested the safety and effectiveness of the DEXTER robotic system in 52 patients having a hysterectomy (removal of the uterus) and related surgery for non-cancerous conditions. The main goals were to see if the robotic procedure could be completed without switching to o…

This study looked at whether doing a mandala coloring activity could lower stress and fear of childbirth in women hospitalized with high-risk pregnancies. 149 pregnant women took part. The researchers measured their anxiety, stress, and fear levels before and after the activity.

This study examines whether two specific ultrasound measurements—the ratio of the transverse cerebellar diameter to abdominal circumference and the ratio of mid-thigh circumference to femur length—can more accurately estimate gestational age in both healthy and growth-restricted …

This study looks at how the womb lining heals after different types of womb-sparing surgery for placenta accreta, a serious pregnancy condition where the placenta grows too deeply into the womb wall. Researchers will use a small camera (hysteroscopy) three months after surgery to…

This completed study examined levels of certain proteins and growth factors in the placentas of 48 women with placenta previa or placenta percreta during the third trimester. Researchers measured substances like decorin, laminin, and collagen in placental tissue and blood samples…

This study looked at whether a 4-week resistance training program is doable for women who had pregnancy complications like preeclampsia or preterm birth. Seven new moms participated, and researchers measured how well they stuck with the exercises and how they felt about them. The…

This completed study looked at 36 pregnant women to understand why the membranes around the baby break too early (PPROM). Researchers measured certain proteins called syndecans in the mother's blood and in the placenta and amniotic membrane after birth. The goal was to find clues…

This study measured a substance called preptin in the umbilical cord blood of 72 newborns. Researchers compared levels in babies with low or high birth weight to those with normal weight, and also looked at babies born to mothers with diabetes. The goal was to see if preptin leve…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study followed 81 pregnant women whose babies were growing slowly in the womb (a condition called IUGR). Researchers used ultrasound to measure blood flow in a key fetal blood vessel every week during the third trimester. They then checked if these measurements could predict…

This study used MRI scans to measure blood flow in the placenta of 135 women undergoing pregnancy termination for fetal reasons between 16 and 32 weeks. The goal was to create a set of normal reference ranges for placental perfusion, which could help doctors identify when the pla…

This study looked at pregnant women at high risk for placenta accreta, a serious condition where the placenta grows too deeply into the womb. Researchers wanted to find out which factors, such as how the condition is diagnosed and managed, affect the mother's health. Over 600 wom…

This study tested a special stitch device (STRATAFIX Spiral PDS Plus) used in robot-assisted surgeries for weight loss (sleeve gastrectomy) and hysterectomy. 161 adults took part. The main goal was to see how well it controlled bleeding after stitching. Doctors also rated how eas…

This study involved 40 pregnant women whose babies were not growing well (fetal growth restriction). Researchers wanted to see if a single session of moderate exercise would change the baby's well-being. They measured the baby's health using ultrasound before and after the exerci…

This study compared robot-assisted laparoscopy using the Senhance Surgical System to conventional laparoscopy for hysterectomy and other uterine surgeries. Researchers measured operating time, blood loss, and safety in 78 patients. The goal was to see if the robot offers advantag…

This study tested whether starting a hysterectomy by cutting the back of the vagina (posterior colpotomy first) helps keep the vagina longer compared to the usual method. Eighty women having a hysterectomy for non-cancer reasons took part. The main goal was to measure any differe…

This study tested a new, noninvasive device that uses light to monitor blood flow and oxygen in the brains of extremely premature babies. Researchers followed 100 infants born before 29 weeks to see if the device could detect problems linked to brain bleeding. The goal is to give…

This completed study looked at whether a blood test for a substance called ADMA can measure blood vessel health in children with growth hormone deficiency or those born small for their age. Researchers compared ADMA levels to ultrasound measurements of artery function in 23 child…

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This study tested whether a special ultrasound scoring system (Placenta Accreta Index) can help doctors decide the safest type of surgery for pregnant women with placenta accreta, a condition where the placenta grows too deeply into the womb. Researchers studied 154 women with pl…

This completed study investigated levels of a protein called CD71 in placentas from 39 women with preeclampsia and 39 healthy pregnant women. Researchers also looked at newborn outcomes. The goal was to better understand how preeclampsia develops. No treatment was tested; this is…

This study measured the amount of free-floating DNA and nucleosomes in the blood of 137 women to see if these levels differ between those with pregnancy complications (like preeclampsia or blood clots) and healthy women (both pregnant and non-pregnant). The goal was to better und…

This study looked at 100 preterm babies who were small for their gestational age and needed IV nutrition. Researchers compared two ways to calculate their nutritional needs: using the baby's actual birth weight versus using a corrected weight (the weight they would be at the 10th…

This study tested whether a special brain MRI could predict which unborn babies with poor growth (intrauterine growth restriction) will have health problems after birth. Researchers scanned 82 fetuses before 32 weeks of pregnancy and compared the results to their health at delive…