Experimental womb fluid therapy aims to save babies with fatal kidney condition

NCT ID NCT03101891

First seen Feb 02, 2026 · Last updated Apr 28, 2026 · Updated 9 times

Summary

This study tests an experimental treatment for pregnant women whose babies have no amniotic fluid because of severe kidney problems. The treatment involves repeatedly adding sterile fluid into the womb to help the baby's lungs grow enough to survive after birth. The study includes 70 participants who choose either to receive the treatment or to have standard monitoring. Babies who survive will need lifelong kidney dialysis and eventually a kidney transplant.

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Contacts and locations

Locations

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Columbia University

    New York, New York, 10032, United States

  • Johns Hopkins Hospital

    Baltimore, Maryland, 21287, United States

  • Mayo Clinic

    Rochester, Minnesota, 55902, United States

  • Stanford University

    Stanford, California, 94305, United States

  • University of California San Francisco

    San Francisco, California, 94158, United States

  • University of Colorado Denver

    Aurora, Colorado, 80045, United States

  • University of Southern California/Children's Hospital of Los Angeles/Huntington Hospital

    Los Angeles, California, 90033, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.