Experimental fetal fluid therapy aims to save babies born without kidneys
NCT ID NCT03101891
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who survive will need intensive care, dialysis, and eventually a kidney transplant. The study is no longer enrolling for one type of kidney problem but continues for others.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
serial amnioinfusions with isotonic fluid
What this could lead to
If it works, this could help babies with severe kidney failure survive birth by improving lung growth, though they will still need lifelong dialysis and a kidney transplant.
What could go wrong
This is an early phase 1 trial with only 70 participants and no random assignment. There is a high risk of early rupture of membranes and premature delivery. The treatment does not fix the kidneys.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Columbia University
New York, New York, 10032, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Mayo Clinic
Rochester, Minnesota, 55902, United States
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Stanford University
Stanford, California, 94305, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Colorado Denver
Aurora, Colorado, 80045, United States
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University of Southern California/Children's Hospital of Los Angeles/Huntington Hospital
Los Angeles, California, 90033, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States