Periapical periodontitis

This study looks at whether placing a calcium hydroxide paste inside a tooth between root canal appointments helps infected teeth heal better. About 110 adults with painful tooth infections will receive standard root canal treatment over multiple visits. One group gets the extra …

This study looks at whether a special dental sealer (bioceramic) helps heal infections and reduces pain after a repeat root canal done in one visit. About 70 adults with failed root canals and silent infections in their back teeth will take part. They will get the new sealer or a…

This study compares two ways to remove infection at the tip of a tooth root: using a rotary bur (a small drill) or a piezoelectric unit (a vibrating tool). 124 adults with root infections will have surgery and then be followed for 12 months to see which method leads to better bon…

This trial tests four methods of activating the cleaning liquid during root canal treatment in adults aged 20 to 40 with an infected lower first molar. The goal is to see which method helps the infection at the root tip heal best after 12 months. Participants receive one-visit ro…

This study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…

This study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…

This study tests whether oleanolic acid, a natural plant compound, works better than standard medicines (calcium hydroxide and Ledermix) when placed inside a root canal. The goal is to reduce bacteria and inflammation in teeth with infection. Thirty-six adults with infected singl…

This early-phase trial tests whether calcium silicate and pectin, placed inside the tooth, can kill bacteria better than standard calcium hydroxide in root canals of dead teeth with abscesses. 63 adults with a single infected premolar will receive one of the three medications. Th…

This study compares two methods to clean infected root canals during a single dental visit: laser-activated irrigation and sonic-activated irrigation. Sixty adults with chronic apical periodontitis (a tooth infection) will receive one of the two treatments. Researchers will measu…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study compares a new calcium silicate-based sealer to the standard resin-based sealer for root canals in molar teeth. About 136 adults aged 18-65 with infected molars will receive one of the two sealers. The goal is to see which material leads to better healing and fewer sym…

This study compares two materials used to seal the tip of a tooth root during surgery for persistent infections after root canal treatment. About 110 adults will receive either MTA or TotalFill BC-RRM Fast Set Putty. Researchers will check healing with 3D X-rays after one year to…

This study compares two types of dental sealers used during root canal treatment: TotalFill (a bioceramic sealer) and AH Plus. The goal is to see which one leads to better healing of infections at the tooth root tip. 170 teeth from adults at a dental clinic in Singapore are being…

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days an…

This study compares two treatments for severe tooth pain: vital pulp therapy, which tries to save the tooth's nerve, and standard root canal treatment, which removes it. Researchers will measure pain after 24 hours and one week, and check healing at 6 and 12 months using AI to re…

This study looks at two ways to clean root canals (rotary vs. reciprocating files) and whether rinsing with very cold saline (cryotherapy) reduces pain after the procedure. Sixty adults with infected but painless teeth will be randomly assigned to one of four groups. Patients wil…

This study tests two ways to clean a tooth during a root canal: laser-activated irrigation and passive ultrasonic irrigation. Researchers want to see which method leads to less pain and better quality of life afterward. 90 adults with infected or damaged permanent teeth are takin…

This study looks at two different cleaning solutions used during root canal treatment for teeth with long-term infection. The goal is to see which method helps the infection heal better and causes less pain afterward. 63 healthy adults with infected front or premolar teeth will b…

This study tests a less invasive surgical approach for treating persistent tooth infections. Instead of removing all infected tissue and using stitches, surgeons remove only part of the tissue and seal the area with a medical glue. The goal is to see if this method reduces pain, …

This study tests whether adding N-acetylcysteine (NAC) to standard root canal treatment can reduce pain and improve healing in people with infected, dead teeth. Forty adults with mature teeth and signs of infection around the root tip will receive either NAC or standard medicatio…

This study looks at two different materials used to fill root canals after infection. 64 adults with infected but painless teeth will get one of the two sealers. Researchers will track pain for a week and check healing with X-rays over time to see which works better.

This study tests whether adding a common mouthwash ingredient (chlorhexidine) to a standard root canal medicine (calcium hydroxide) helps reduce pain after treatment. 80 adults with infected front teeth will receive one of two mixtures. Pain levels are checked at 12, 24, and 48 h…

This study tests two different pastes placed inside the tooth between root canal visits to see which one reduces pain and helps the bone heal better. Eighty adults with infected but painless front teeth will receive either Bio-C Temp or Metapaste. Pain is tracked for a week, and …

This study looks at three different methods to activate cleaning fluids during root canal retreatment: ultrasonic, sonic, and laser. The goal is to see which one causes the least pain and helps the infection heal best. Seventy-five adults with previously treated teeth that still …

This study follows up to 500 people with acute or chronic inflammatory disorders, such as infections or immune problems, over time. Researchers will monitor participants with standard tests and may screen them for other studies. The goal is to better understand these conditions a…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study collects blood, urine, and tissue samples from 330 adults with advanced lung or head and neck cancer to improve precision medicine. Researchers will analyze genetic changes in these samples and grow some tumors in mice to compare DNA. The goal is to refine liquid biops…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study checks how many teeth remain functional 10 years after root canal treatment using a sealer called Endomethasone N. Researchers will review records from 179 adults who had the treatment at least 5 years ago. The goal is to understand the long-term success and safety of …

This study looks at whether a person's genetic makeup influences how well a tooth infection heals after root canal treatment. Researchers will collect saliva samples from 96 adults with chronic apical periodontitis and analyze specific genes related to inflammation and bone repai…

This study looks at how an acute tooth infection (apical periodontitis) affects the masseter muscle, a key jaw muscle used for chewing. Researchers will use ultrasound to measure muscle thickness and stiffness before and after dental treatment with calcium hydroxide. The goal is …

This study follows 60 adults with infected teeth who receive standard root canal treatment. Researchers collect fluid from around the tooth before and after treatment to see if certain proteins can predict whether the infection heals on X-rays after one year. The goal is to find …

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study looks at how different root canal cleaning methods—laser and ultrasound—affect the immune response in people with and without type 2 diabetes who have a tooth infection called apical periodontitis. Researchers will measure certain immune markers in fluid from around th…

This study tests whether using ozone water during root canal treatment can reduce oxidative stress (a sign of inflammation) in the jawbone. Sixty adults with a single-rooted tooth and a silent infection will be randomly assigned to receive either ozone water or salt water as a fi…