Periapical periodontitis

This study tests whether a special irrigation solution called nanochitosan can help regenerate damaged tissue in infected teeth. Sixty adults with dead teeth and chronic infection will receive one of three irrigation methods during a single dental visit. Researchers will check fo…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This study looks at how well 3D printed bone grafts work for supporting dental implants in people with gum disease or bone loss. Researchers will check if the implants stay stable and how much the graft shrinks over 1 to 6 years. About 100 healthy adults who already received this…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study compares a new cleaning solution made from ferumoxytol nanozymes to the standard treatment for root canal infections. About 72 adults with infected teeth will receive either the new solution or the usual one during their root canal procedure. Researchers will measure h…

This study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will compare …

This study compares two materials used to fill root canals during retreatment of infected teeth: standard gutta-percha and a newer material called MTA. About 58 adults with small infections around the tooth root will be treated and followed for one year. Researchers will check he…

This study compares two medicines placed inside a tooth after root canal treatment to see which one helps heal infections around the tooth root faster. About 62 adults with infected single-rooted teeth will receive either triple antibiotic paste or calcium hydroxide. The research…

This study tests whether using a donor bone graft (allograft) works as well as using your own bone (autograft) to repair defects where a tooth infection has damaged the surrounding bone. Fifty adults with these defects will receive one of the two grafts along with a collagen memb…

This study looks at whether adding other medicines to a standard root canal disinfectant (calcium hydroxide) can kill more bacteria in infected teeth. The trial will involve 45 adults with a tooth infection called apical periodontitis who need a repeat root canal. Researchers wil…

This study tests whether using platelet-rich fibrin (PRF) – a concentrate made from a patient's own blood – can reduce pain and improve healing after endodontic microsurgery (root-end surgery). Twenty adults with failed root canals and persistent infection in front teeth or premo…

This study tests if garlic gel can replace the usual medicine placed inside teeth during root canals. About 96 people with infected permanent teeth will get either garlic gel or calcium hydroxide. Researchers will check pain, swelling, and X-ray healing to see if garlic works as …

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This study tests whether a less invasive dental procedure called full pulpotomy can heal infected molars as well as root canals. Researchers will treat 128 adults with deep cavities and compare healing in teeth with and without infection at the root tip. If successful, it may off…

This study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether a newer bioceramic filling material reduces pain after root canal treatment better than the standard calcium hydroxide filling. Twenty-eight adults with painful lower molar infections will receive one of the two fillings during their root canal. Pain leve…

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study compares two single-dose pain relievers—piroxicam and prednisolone—given before a root canal to see which one reduces pain better afterward. Sixty adults with an inflamed tooth nerve and infection will take one of the drugs right before treatment. The goal is to find a…

This study will test if a technique called 'apical patency'—gently passing a small file just past the root tip during cleaning—can reduce pain after a root canal. 48 adults with a dead nerve and infection in a back molar will be randomly assigned to receive either this technique …

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study gathers mouth pictures from 150 adults with different gum conditions to teach an AI system how to spot gum disease. Participants simply have their teeth and gums photographed with a special probe. No treatment or medication is involved—just data collection to improve f…

This study will check if certain gene variations (MMP-2 and MMP-3) are linked to how well the bone around a tooth heals after root canal treatment. Fifty adults with chronic tooth infections will get standard root canal therapy and be followed for 12 months. Researchers will comp…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

This study looks at how much final-year dentistry and psychology students know about gum disease (periodontitis) and whether that knowledge is linked to their own gum health. About 60 students will fill out a questionnaire and get a dental check-up. The goal is to see if more kno…

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at how well root canal treatments work when done in general dental clinics, rather than specialist offices. Researchers will check about 1500 patients who had root canals in 2023 to see if infections remain after treatment. The goal is to understand why results m…