Osteonecrosis

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…

This early-stage trial tested a new gene therapy called FLT201 in 10 adults with Gaucher disease type 1. The therapy uses a harmless virus to deliver a working copy of the gene that produces a missing enzyme. The main goal was to check safety and see if the treatment can boost en…

This study tested a triple therapy—surgery, stem cells, and hyperbaric oxygen—in 24 patients with early-stage osteonecrosis (bone death) of the hip. After two years, patients reported better hip function and fewer needed a hip replacement. The approach aims to stop the bone from …

This study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …

This study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured us…

This study tested a new shoulder implant called the Catalyst CSR System in 87 people with shoulder arthritis or bone damage. The implant is designed to preserve more natural bone than traditional replacements. Researchers measured pain, movement, and implant safety over two years…

This study looked at 22 people with jaw bone damage caused by medications for osteoporosis or cancer. They all had surgery to remove the damaged bone. Half also received a gel made from their own blood (platelet-rich fibrin) placed into the wound. The goal was to see if this gel …

This study tested whether adding bone graft fibers instead of particles to a standard bone substitute leads to more new bone growth in the upper jaw. Twenty-six adults needing sinus augmentation before dental implants received both types of graft material. Researchers measured bo…

This study tested whether hyperbaric oxygen therapy (HBOT) can help heal severe tissue damage caused by past radiation treatment. 39 adults who had radiotherapy and developed serious radiation injuries received HBOT sessions in a pressurized chamber while breathing pure oxygen. T…

This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. T…

This study looked at how well a specific hip replacement system (the Allofit IT Shell with Longevity Liners) works over 10 years. 197 people with hip problems like arthritis or bone death received the implant. The main goal was to see how many implants were still in place without…

This study tested a new way to rebuild lost jaw bone using a patient's own stem cells mixed with a 3D-printed scaffold. Seven adults with missing teeth in the front of the mouth received the treatment. The goal was to see if this approach could safely create enough new bone to su…

This study tested a new implant called Agili-C for people with knee cartilage damage or early arthritis. 251 participants received either the implant or standard surgery. The goal was to see if the implant improved pain and function over 5 years. Results suggest it may be a helpf…

This study compared two surgical methods to repair damaged knee cartilage: a newer cell-based technique (autologous chondrocyte implantation) and a standard bone-graft method (mosaicoplasty). 58 adults aged 18-50 with isolated knee lesions took part. The goal was to see which app…

This pilot study tested whether applying prescription fluoride varnish to teeth every three months during the first year after radiation therapy for head and neck cancer can reduce cavities and gum problems. 13 adults with at least 4 natural teeth and certain cancers took part. T…

This study tested a robotic system called CORI that helps surgeons plan and perform knee replacement surgery. The goal was to see if the robot helps place the new knee joint more accurately. 126 adults who needed a partial or total knee replacement took part. The results showed t…

This study looked at how well a specific knee replacement, the Medacta GMK Sphere, works over time. Researchers measured how often patients forgot about their artificial knee in daily life, two and five years after surgery. The study involved 260 adults with osteoarthritis who ne…

This study followed 76 adults who received a total shoulder replacement using the MIRAI modular prosthesis. Researchers measured how well the shoulder functioned and how stable the implant was over five years. The goal was to see if the implant helps patients move better and last…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested whether keeping blood pressure in a lower, healthier range could prevent a painful bone condition called osteonecrosis in children and young adults being treated for leukemia. Fifty-one participants were randomly assigned to either intensive or standard blood pr…

This study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…

This study compares two types of Pilates—one done in water and one on a mat—to see which better improves breathing, mobility, and quality of life in older women with a curved upper spine (kyphosis). Forty women aged 55 to 65 with mild to moderate kyphosis will follow a 12-week pr…

This study tested whether a non-opioid pain regimen (celecoxib plus acetaminophen) works as well as an opioid regimen (oxycodone plus acetaminophen) for pain after ankle arthroscopy. 112 adults were randomly assigned to one of the two groups. The goal is to find a safer way to ma…

This pilot study tested a combined program of hold-relax stretching and progressive exercises in 6 adolescent athletes with Osgood-Schlatter disease. The goal was to see if it could reduce knee pain and improve range of motion. Results are preliminary and need confirmation in lar…

This study compared two types of exercises—thoracic extension and global postural corrective exercises—in 30 adults with hyper kyphosis (excessive rounding of the upper back). Researchers measured pain, range of motion, and posture to see which approach worked better. The goal wa…

This study compared two types of exercise—back extensor strengthening and core stability—in 40 adults aged 18-40 with mild to moderate thoracic kyphosis (a rounded upper back). Participants did exercises for 6 weeks, and researchers measured changes in pain, spinal movement, post…

This study looked at whether adding kinesiotape to standard quadriceps strengthening exercises improves knee strength, pain, and function in 60 young adults (ages 18-25) with Osgood-Schlatter disease. Participants did leg exercises with or without the tape. The goal was to see if…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study looked at two treatments for Osgood-Schlatter disease, a common cause of knee pain in growing teens who play sports. One group wore a leg cast for 4 weeks followed by physical therapy, while the other group stopped all sports for 8 weeks and did physical therapy. The g…

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study tested a 12-week home exercise program for heart rehab patients with hyperkyphosis (excessive forward curve of the upper back). 62 participants were split into three groups: those doing the home exercises plus standard rehab, those doing only standard rehab, and those …

This study tested a 12-week holistic exercise program for 62 teenage boys with thoracic kyphosis (excessive rounding of the upper back). One group did corrective exercises plus postural awareness training, while another did only back-focused exercises. Both groups saw improvement…

This study tested a hands-on technique called diaphragmatic myofascial release in 44 adults with thoracic kyphosis (excessive rounding of the upper back). The goal was to see if releasing tension in the diaphragm muscle could improve chest expansion and heart rate. Participants r…

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study follows up with head and neck cancer patients about 7 years after they finished radiation therapy. Researchers will check for cavities, gum disease, tooth loss, bone damage, and saliva flow. The goal is to understand the long-term dental side effects of cancer treatmen…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This early-stage study tested the safety and tolerability of a new drug called RAB001 in 16 healthy adults. Researchers gave single and multiple injections at two dose levels to see how the body handles the drug and if it causes side effects. This is a first step before testing t…

This study looked at bone tissue from 34 men who had hip replacement surgery due to femoral head necrosis (bone death in the hip joint). Researchers used advanced imaging and spectroscopy to identify changes in bone structure and composition. The goal was to better understand wha…

This study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether patients need a blood transfusion. 102 patients were randomly assigned to get a drain or not. The goal is to see if drains help or hurt in terms of blood loss…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study measured the stiffness, tone, and elasticity of back and chest muscles in 88 adults with and without hyperkyphosis (excessive rounding of the upper back). Researchers used a handheld device and a flexible ruler to compare muscle properties and spinal curvature. The goa…

This study measured levels of brain chemicals related to oxidative stress and inflammation in people with type 1 Gaucher disease and healthy volunteers. Researchers gave 33 participants with Gaucher disease the antioxidant N-acetylcysteine (NAC) for about 90 days to see if it cha…

This study looks at how the position of the shoulder blade relates to arm movement, strength, and performance in children aged 7 to 14 with a rounded upper back (thoracic hyperkyphosis). Researchers measured shoulder blade position, joint motion, muscle strength, and upper body f…

This study examined the connection between a rounded upper back (thoracic kyphosis) and shoulder pain, movement, strength, and daily function in 30 adults aged 18 to 60 with a kyphosis angle over 40 degrees. Researchers measured the curve of the spine, pain levels, shoulder motio…

This study looked back at 54 people who had a hip replacement with a specific part called the CL TRAUMA cemented stem. The goal was to see if the part was safe and worked well. Researchers measured how well patients could move and if they had pain using a standard hip score.

This study looked at 14 men with no teeth in their lower jaw to compare two types of connectors (multiunit abutments vs. OT Equator abutments) for implant-supported dentures. The goal was to see which connector led to less bone loss around the implants over 9 months. X-rays were …

This study reviewed existing research on poor posture (like forward head posture and rounded shoulders) in children aged 6 to 18. It looked at how growth and daily activities, such as using technology, affect posture. The goal was to identify gaps in knowledge and suggest ways to…

This completed study looked at 151 children with common postural conditions like flat feet, knock knees, or scoliosis. Researchers used wearable motion sensors and clinical tests to measure balance and motor control, then compared the results to healthy children. The goal was to …

This study followed 162 people who received a G7 hip cup system during hip replacement surgery. Researchers measured pain, function, and hip movement using standard scores. The goal was to see how the device performs in everyday patients with arthritis or other joint problems.

This study looked at 110 adults with different hip problems, such as arthritis or labral tears, to understand how these conditions affect posture, muscle strength, balance, pain, and quality of life. Researchers used special 3D imaging and pain tests to measure these factors. The…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at 40 people who had a total hip replacement through a small incision in the front of the hip. Researchers compared two types of metal stems (AMIStem and Quadra) to see how bone density around the implant changed one year after surgery. The goal was to find out …

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study tested whether a smartphone inclinometer app can reliably measure the forward curve of the upper spine (thoracic kyphosis) compared to a standard flexible ruler. Sixty adults with at least a 30-degree curve were measured by two different raters. The goal was to see if …