Could an antioxidant help gaucher disease? new study investigates

NCT ID NCT02583672

Completed Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study measured levels of brain chemicals related to oxidative stress and inflammation in people with type 1 Gaucher disease and healthy volunteers. Researchers gave 33 participants with Gaucher disease the antioxidant N-acetylcysteine (NAC) for about 90 days to see if it changed these chemical levels. The goal was to understand the role of oxidative stress in the disease, not to test a cure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: N-acetylcysteine (NAC)
What this could lead to: If successful, this could point toward using antioxidants like NAC to reduce inflammation and oxidative stress in Gaucher disease.
What could go wrong: This is a small, early-phase study with only 33 participants, focused on measuring chemical changes rather than clinical improvement. Results may not lead to a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Gaucher disease Gaucher disease type I

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GAUCHER DISEASE TYPE 1

Contacts and locations

Locations

New York University

New York, New York, 10016, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States

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