Osteonecrosis

This trial asks whether it is safe to skip the routine removal of impacted teeth before radiation therapy for nasopharyngeal carcinoma. Half of the participants will have the extraction as usual, while the other half will not. The study will compare the risk of jaw bone damage (o…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to a standard hip procedure (core decompression with bone marrow cells) can reduce pain in people with early-stage avascular necrosis of the hip. The trial will enroll 400 p…

This study investigates whether a patient's own platelet concentrate, called A-PRF, can improve early wound healing after tooth extraction in people at high risk for medication-related osteonecrosis of the jaw (MRONJ). Participants are adults who have taken or are taking bone-str…

This study compares two surgical methods for repairing large cartilage defects in the knee: augmented microfracture (AMT) and matrix-assisted chondrocyte implantation (MACT). It will enroll 80 people aged 15-50 with symptomatic defects. The goal is to see which technique better i…

This study compares a new scaffold implant (MaioRegen Prime) to standard surgical cleaning (debridement) for treating deep cartilage lesions in the knee. About 400 patients aged 18-60 with knee lesions will be randomly assigned to one of the two procedures. The main goal is to se…

This study tests whether a substance made from a patient's own blood, called platelet-rich fibrin (L-PRF), can prevent a serious condition called jawbone death after tooth extraction. The trial will include 40 people at high risk due to past radiation or certain medications. Half…

This study tests whether adding a mind-body therapy called Basic Body Awareness Therapy (BBAT) to standard corrective exercises can improve body image, self-esteem, and posture in 60 adolescents with postural hyperkyphosis (a rounded upper back). Participants will do exercises tw…

This study compares two non-invasive treatments—kinesio taping and dry cupping—for people with thoracic kyphosis (an excessive rounding of the upper back). Researchers will measure changes in pain and the angle of the curve in 48 physically active adults aged 18 to 30. The goal i…

This study compares two surgical techniques for treating medication-related osteonecrosis of the jaw (MRONJ), a condition where jawbone dies due to certain drugs. Thirty-four adults with stage 1 or 2 MRONJ will be randomly assigned to receive either traditional rotary instrument …

This study tracks 30 people receiving a CATALYSTEM cementless hip implant to measure how much the stem moves (subsides) in the thigh bone over two years. Using specialized CT scans, researchers aim to see if the implant stays firmly in place, which is key for long-term success. P…

This study is developing a way to predict who might develop a serious jaw bone condition called medication-related osteonecrosis of the jaw (MRONJ) after dental procedures. Researchers are following adults who have taken bone-strengthening drugs like bisphosphonates or denosumab …

This study will look at how jaw bone quality changes over time in patients with medication-related osteonecrosis of the jaw (MRONJ), a side effect of drugs like bisphosphonates. Researchers will analyze existing CBCT scans from 25 adults to measure bone density and structure at d…

This study looks at how diastasis recti abdominis (a separation of the belly muscles) relates to spine curvature in women who recently gave birth. Researchers will measure spine angles in 110 women aged 21-35, both with and without the condition, using safe, non-invasive methods.…

This study will use DEXA bone scans to see how the CoreHip hip replacement stem affects bone density around the implant over two years. Forty adults with hip arthritis or other hip conditions will be enrolled. The goal is to understand if the implant's design helps maintain healt…

This study looks at whether manual therapy (hands-on treatment) on the upper back can improve posture and oxygen levels in people who use e-cigarettes. Researchers will measure changes in spine curvature and blood oxygen in 20 adult participants. The goal is to see if this simple…