Attention deficit-hyperactivity disorder

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial is testing whether an experimental medication called centanafadine, taken once daily as extended-release capsules, can help adults with attention-deficit/hyperactivity disorder (ADHD) who also experience emotional dysregulation—difficulty managing emotions like irritab…

This phase 2 trial explores whether fecal microbiota transplantation (FMT) is safe, tolerable, and practical for adolescents aged 13–17 with ADHD. Participants receive oral FMT capsules after bowel prep, alongside antibiotics, to see if changing gut bacteria can influence ADHD sy…

General anesthesia in early childhood may raise the risk of ADHD-like behaviors and learning problems later on. This trial tests whether a non-invasive device delivering synchronized 40-Hz light and sound can help restore brain function after surgery. Researchers will monitor bra…

This trial tests a 12-week home-based program called SPRINT for infants aged 7-15 months who were born preterm or have a family history of conditions like ADHD, autism, or developmental delay. Parents use an app to guide daily play activities aimed at improving parenting skills a…

This study tests whether Foquest, a once-daily extended-release methylphenidate capsule, is safe and effective for treating ADHD in adults aged 65 and older. Participants take the medication for about 10 weeks, starting at 25 mg and adjusting up to 100 mg based on response. The m…

This trial tests whether the MIND diet, a brain-healthy eating plan rich in vegetables, berries, nuts, and fish, can reduce ADHD symptoms in children aged 6 to 12 who are not taking medication. Over 12 weeks, half the children follow the MIND diet while the other half receive sta…

This phase 3 trial tests whether viloxazine extended-release capsules, taken once daily, can safely reduce ADHD symptoms in Korean children and adolescents aged 6 to 17. Participants receive either the drug or a placebo for 8 weeks, with doses adjusted based on response. The stud…

This study tests a special type of talk therapy (cognitive-behavioral therapy, or CBT) designed for adults with ADHD who are in prison. Researchers will compare it to a standard prison program and a waitlist. They want to see if the therapy reduces ADHD symptoms, depression, anxi…

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …

This study tests a new system called AHEF designed to help doctors diagnose attention-deficit/hyperactivity disorder (ADHD) in children aged 6 to 12. The trial includes children with possible ADHD symptoms as well as healthy children, and measures how accurate and safe the system…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This trial tests whether cognitive behavioural therapy for insomnia (CBT-I), with or without bright light therapy, can improve sleep and other outcomes in adolescents with ADHD who also have insomnia and a late sleep schedule. Participants aged 10-24 will receive CBT-I plus eithe…

This study tests a new, non-drug treatment for veterans with ADHD who still struggle with impulsivity despite medication. The treatment, called intermittent theta-burst stimulation (iTBS), uses magnetic pulses to gently stimulate brain areas linked to self-control. Thirty-five ve…

This study investigates whether a synbiotic supplement—a mix of probiotics and prebiotics—can improve emotion regulation and reduce gastrointestinal problems in adults with ADHD. Participants take either the synbiotic or a placebo capsule daily for 12 weeks. The main focus is on …

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This trial tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce inattention in adults with ADHD. Forty adults with ADHD will receive either real or fake tDCS for five days in a row. Researchers will meas…

This study will test whether adding music therapy to standard physical therapy helps children with spastic cerebral palsy improve their concentration and walking. Forty children aged 5 to 7 will either receive physical therapy alone or physical therapy combined with rhythmic musi…

This study tests whether daily iron supplements can improve restless sleep and ADHD symptoms in 70 children with ADHD who have low iron levels. Participants will take either iron or a placebo for 3 months, and their sleep and attention will be measured using motion-sensing leg ba…

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study tests whether a home-based music program can improve attention and thinking speed in people who have had a stroke. About 36 Malaysian stroke survivors with mild to moderate cognitive issues will take part. They will use music exercises at home, with help from a caregiv…

This study looks at whether a therapy called Acceptance and Commitment Therapy (ACT) can help fathers of children with special needs feel more flexible in their thinking and improve their mental health. About 50 fathers will take part, with half getting ACT and the other half rec…

This study tests whether a virtual reality system (VRRS) can improve executive functions like memory, planning, and attention in 50 children aged 8-12 with ADHD. Kids will do 12 sessions of VR-based cognitive exercises over 6 weeks. Researchers will also check if these skills hel…

This study will test whether adapted karate training can improve self-regulation, daily function, and social participation in children aged 6-12 with ADHD. Fifty-five participants will either receive karate training first or wait, then switch. The training involves two 60-minute …

This study tests if a diet rich in fiber and fermented foods can reduce core ADHD symptoms in adults aged 18-50. Two hundred participants will be randomly assigned to either this special diet or standard healthy eating advice for 12 weeks. Researchers will track changes in sympto…

This study will compare two behavioral programs for children aged 9-12 with ADHD: the OutSMARTers group program and individual counseling. About 100 children will be randomly assigned to one of the programs or a short waitlist. Researchers will measure changes in behavior, emotio…

This study tests whether playing a virtual reality game called Electrical Maze can improve sustained attention in neurodivergent children aged 9 to 18, including those with autism, ADHD, or learning differences. Over 6 weeks, 40 participants will play the VR game twice a week for…

This study compares two medications, methylphenidate and guanfacine, to see which works better for treating ADHD in children ages 3 to 5. About 370 children with moderate to severe ADHD will take one of the drugs, and doctors will rate how much their symptoms improve. The goal is…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce symptoms of ADHD and autism in children and teens aged 6-19. Participants will receive either real or sham (fake) stimulation over three weeks. The goal is to see if it is safe and if it im…

This study tests whether intensive music-based rhythm training can improve attention, thinking, and reading in children aged 8 to 10 with complex neurodevelopmental disorders (like ADHD plus dyslexia). Six children will take part in a structured program, and researchers will meas…

This study will test a new, non-invasive treatment called transcranial photobiomodulation (tPBM) for children with ADHD. The treatment uses light to stimulate the brain. Researchers will enroll 54 children aged 6 to 18 to see if tPBM can improve ADHD symptoms, sleep, and brain ac…

This study looks at whether children with ADHD and their parents will actually use a digital app called LUSHA for three months. The app is designed as a game to motivate behavior change and improve parent-child interaction. Researchers will track how often families use the app an…

This study looks at whether structured breathing exercises can help 12th graders reduce exam anxiety, improve attention, and boost academic performance. Sixty students preparing for university entrance exams will practice specific breathing techniques over several sessions. Resea…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This observational study looks at whether snack consumption and eating behavior are linked to the severity of ADHD in children aged 6 to 12. Researchers will survey children with ADHD and a control group about their eating habits and snack choices. The goal is to understand if ce…

This study investigates whether one year of boxing training can improve attention in adolescent athletes aged 13-15. Researchers will use the Attention Network Test to measure changes in alerting, orienting, and executive control. The goal is to understand how boxing affects brai…

This study looks at how common heart problems are in children with ADHD. Researchers will compare 50 children with ADHD who take medication to 50 healthy children. They will use ECG and echocardiograms to check for heart issues.

This study tests whether a simple, non-invasive brain test (EEG) can predict which of two common ADHD medications—methylphenidate or amphetamines—works best for a child. About 220 children aged 7-11 with ADHD will try both medicines in a random order over 7 weeks. The goal is to …

This study looks at whether drinking caffeinated coffee helps professional chess players think faster and make better moves during tournament games. Twelve top-level players (rated 2300-2600 Elo) will play chess after drinking either regular coffee or decaf, without knowing which…

This study will check how often people with ADHD also have fibromyalgia, and vice versa. Researchers will collect blood and urine samples from 100 adults to look for shared biological markers. The goal is to better understand why these two conditions often occur together.

This study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …

This study aims to create a therapy program using Acceptance and Commitment Therapy (ACT) for fathers of children with special needs in Hong Kong. Researchers will interview 20 fathers and social workers to understand their challenges and what kind of support would help. The goal…

This study is looking for early clues—like brain activity, genetics, and environment—that might predict autism, ADHD, and related mental health issues in children and young adults. Researchers will follow 800 participants from infancy through young adulthood across 10 internation…

This pilot study will test whether eye-tracking and balance tests can help identify early signs of ADHD in children aged 3 to 5. Researchers will compare 30 children with ADHD symptoms to 30 healthy children of the same age. The goal is to develop a platform for earlier detection…

This study looks at whether children with ADHD have different levels of inflammation and nutrition markers compared to children without ADHD. Researchers will follow 80 children aged 7 to 17 for one year to see if these markers affect how well they respond to common ADHD medicati…

This study aims to create a system to assess and improve motor skills in children aged 4 to 12 with neurodevelopmental disorders like ADHD. Researchers will test different exercise programs to see which ones best help these children move better and think more clearly. The goal is…

This observational study will look at 185 children with epilepsy to find out how many also have ADHD symptoms. Researchers will track changes in ADHD symptoms and quality of life over 12 weeks. The goal is to identify risk factors and understand how ADHD affects epilepsy outcomes…