Aortic aneurysm

This trial is testing a specially modified stent graft—a small mesh tube—to repair complex aortic aneurysms in people who are too high-risk for open surgery. The graft is adjusted by the physician to keep blood flowing to the kidneys and other vital organs during the procedure. T…

This study looks at how well the iCover stent works when used as a bridging stent during a procedure called fenestrated endovascular aneurysm repair (fEVAR) for complex abdominal aortic aneurysms. The goal is to see if the stent stays open and keeps the aneurysm sealed without co…

This study tracks the safety and effectiveness of the GORE® TAG® Thoracic Branch Endoprosthesis, a stent-graft device used to treat aortic arch and descending aorta conditions such as aneurysms, dissections, and transections. Researchers will follow about 155 patients who receive…

This study tests whether adding a special implant (IMPEDE-FX RapidFill) during standard aneurysm repair helps shrink the aneurysm sac more effectively. About 180 adults with large abdominal aortic aneurysms will receive the implant alongside their usual stent graft. The goal is t…

This study follows 300 people who received the GORE TAMBE device to treat complex aortic aneurysms. The goal is to confirm the device works safely and effectively outside of clinical trials. Researchers will track technical success and patient outcomes over 12 months.

This study tests a special stent device (GORE EXCLUDER) to treat thoracoabdominal and pararenal aortic aneurysms—bulges in the main artery that can rupture. About 102 people will receive the stent through a minimally invasive procedure. Researchers will check if the device is pla…

This study tests a special chimney graft technique for people with a type of aortic aneurysm that is hard to treat because it is close to the kidneys. The goal is to see if this method is safe and works well in everyday medical practice. About 150 adults will take part, and resea…

This study tests a special tube called a stent graft to repair damage in the upper part of the main artery from the heart (the ascending aorta). It is for people with bulges (aneurysms), tears (dissections), or other lesions that usually need open-heart surgery. The goal is to se…

This study follows 164 people with abdominal aortic aneurysm who receive the Ankura stent graft system, a device placed inside the aorta to reinforce the weakened area. Researchers will track major complications and treatment success over 12 months. The goal is to see how well th…

This study is following 147 people who have a bulge (aneurysm) or tear (dissection) in the main artery of the chest. All participants received the Ankura stent graft, a fabric-covered metal tube placed inside the artery to support it. Researchers are tracking how well the device …

This study looks at how well new, custom-made and off-the-shelf stent-grafts work for repairing complex aortic aneurysms (bulges in the main artery). About 750 people with aneurysms in the abdomen, chest, or arch will be treated using a less invasive procedure through blood vesse…

This study is testing a less invasive procedure using stent-grafts to treat various types of aortic disease, including aneurysms and dissections. It involves 170 participants who are considered too high-risk for traditional open surgery. The goal is to see if this endovascular ap…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study is testing a new device called the ChEVAS System for people with complex abdominal aortic aneurysms (bulges in the main blood vessel near the kidneys). The device is placed inside the blood vessel using a catheter, avoiding open surgery. Only 13 people are enrolled, an…

This study is testing a new stent device called the GORE® TAG® Thoracic Branch Endoprosthesis to treat aneurysms or lesions in the aortic arch and upper part of the main artery from the heart. About 250 participants will receive the device to see if it is safe and effective. The …

This study provides expanded access to a new device called the GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis for people with thoracoabdominal or pararenal aortic aneurysms. These are bulges in the main artery that involve branches to vital organs. The device is a stent-gra…

This study is testing a device called the E-nside stent graft system in 30 people with thoracoabdominal aortic aneurysms (a bulge in the main artery that runs through the chest and belly). The goal is to see if the device is safe and works well when placed inside the artery to re…

This study is testing a special stent graft system designed to treat thoracoabdominal aortic aneurysms, a life-threatening condition where the main artery bulges. The device is placed inside the artery to support the weakened wall and prevent rupture. Researchers are following 15…

This observational study follows 352 adults with aortic arch or descending aorta disease who receive the Thoraflex Hybrid device, sometimes with an additional RelayPro stent-graft. The goal is to evaluate safety and treatment success over 10 years, including risks like stroke, sp…

This study tests a new device called the Treovance Stent-Graft to treat abdominal aortic aneurysms (a bulge in the main artery). The device is placed inside the artery to reinforce the weak spot and prevent rupture. About 158 adults aged 18-85 with aneurysms large enough to need …

This study tests whether giving two drugs—Ulinastatin and Thymosin α1—right after emergency surgery for a torn aorta can prevent dangerous body-wide inflammation and organ failure. About 200 adults will receive the drugs, and doctors will track their organ function for a week. Th…

This study tests whether a special plug can safely fill the leftover space inside an abdominal aortic aneurysm after standard stent repair. The goal is to prevent blood leaks (endoleaks) and help the aneurysm heal. Fifteen adults with large aneurysms will receive the plug during …

This study tests a device called IMPEDE-FX that is used to fill the empty space around a stent graft after standard abdominal aortic aneurysm repair. The goal is to see if it is safe and can prevent blood from leaking into the aneurysm sac. The trial involves 15 adults who are al…

This study tests a new device called the Nectero EAST System in 46 people with abdominal aortic aneurysms (AAA). The goal is to see if it is safe and can stop the aneurysm from growing, reducing the need for major surgery. Participants receive the device through a catheter, and d…

This study planned to test a branched stent-graft for treating aneurysms in the aortic arch, a high-risk area near the heart. The goal was to see if the device could be safely placed and hold up over time. However, the study was withdrawn before enrolling any participants, so no …

This trial tests a 6-week program called Ready for Recovery that helps people prepare for aortic aneurysm surgery. The program includes education, healthy habits, stress reduction, and social support. Ten adults having elective surgery will participate to see if the program is fe…

This study follows 60 people with abdominal aortic aneurysm who are scheduled for endovascular repair (EVAR). Researchers will measure artery stiffness, heart structure and function, and certain blood markers before the procedure and at several points afterward. The goal is to un…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study explores whether a special 3D ultrasound technique, called vector flow imaging, can predict where blood clots form inside abdominal aortic aneurysms. Researchers will scan 14 people with small aneurysms (under 5.5 cm), half with existing clots and half without. They wi…

This study uses a non-invasive ultrasound device to monitor blood flow and detect tiny clots traveling to the brain during placement of a specialized stent-graft for thoracic aortic aneurysms or dissections. Researchers aim to understand how often these microemboli occur and how …

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study looks at skin cells (fibroblasts) from people with Marfan syndrome and other genetic conditions that cause thoracic aortic aneurysms (a bulging of the main artery in the chest). Researchers want to find out how these cells behave differently and what genes or proteins …

This study follows 2000 people who received the AFX2 system, a device to repair abdominal aortic aneurysms. Researchers will track complications like rupture, need for further procedures, and death over 5 to 10 years. The goal is to see how well the device performs in real-world …

This study looks at whether brothers, sisters, and children of people who have had an abdominal aortic aneurysm are more likely to develop one themselves. Researchers will analyze health records from nearly one million people in Sweden. The goal is to better understand how family…

This study follows 770 people who had aortic aneurysm repair using branched stent grafts. Researchers will check kidney function and other organ health over two years to see how different stent designs affect outcomes. The goal is to learn which approaches work best for preservin…

This study is collecting data from 400 people with abdominal aortic aneurysms to improve how doctors predict aneurysm growth. The goal is to create more personalized monitoring plans. Participants will have regular check-ups and imaging tests to track changes over time.

This study uses painless ultrasound scans to check for hidden bulges (aneurysms) in the belly and behind the knee in 507 people at higher risk, including older women who smoke and men over 65. The goal is to learn how common these bulges are and what risk factors are linked to th…

This study from Mayo Clinic aims to see how common a widened aorta (thoracic aorta dilatation) is among experienced weightlifters over age 35. Researchers will use ultrasound to measure the aorta in 45 participants who have been lifting weights for at least 5 years. The goal is s…

This study follows 300 people who already received a Zenith® Alpha Thoracic Endovascular Graft to treat a thoracic aortic aneurysm or ulcer. Researchers are checking how well the device works and how safe it is over the long term, especially looking at deaths related to the aorti…

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This study involves 40 adults undergoing aortic arch surgery to repair aneurysms or dissections. Researchers are testing a new bedside system that measures brain chemicals in near real-time to detect early signs of oxygen deprivation. The goal is to prevent strokes and confusion …

This study looks at whether people with an abdominal aortic aneurysm (a bulge in the main artery in the belly) have lower selenium levels than those without the condition. Researchers will compare 40 participants: half with the aneurysm and half without. The goal is to see if sel…

This observational study examines how the nervous system works in 139 adults with thoracic aortic aneurysms (a bulge in the chest's main artery). Participants lie down and then stand while their blood pressure and breathing are monitored non-invasively. The goal is to see if nerv…