Tongji Hospital

This study looks at whether removing extra lymphoid tissue in the back of the nose during standard sinus surgery can better control inflammation in people with nasal polyps. Thirty-two adults with nasal polyps and high blood eosinophils will be randomly assigned to get either sta…

This study tests a combination of two drugs—tislelizumab (an immunotherapy) and huaier granule (a traditional Chinese medicine)—as the first treatment for people with liver cancer that cannot be removed by surgery. About 94 adults will receive this combination to see if it shrink…

This study tests a new treatment called KD01, a modified virus that targets and kills cancer cells, for women with cervical or endometrial cancer. In Phase I, it is given to patients whose cancer has not responded to other treatments. In Phase II, it is tested in younger women wh…

This study tests whether a special high-MCT nutritional formula given before and after Kasai surgery can improve growth in infants with biliary atresia, a rare liver disease. About 120 infants under 3 months old will receive either the special formula or standard feeding. The goa…

This study tests a new combination of four drugs for people with advanced bile duct cancer that cannot be removed by surgery. The treatment adds an immunotherapy drug (adebrelimab) and a common cholesterol-lowering drug (simvastatin) to standard chemotherapy. The goal is to see i…

This study compares two anesthetics—ciprofol and propofol—to see which better prevents heart injury after non-cardiac lung surgery. About 1,058 adults aged 45 to 80 having video-assisted thoracoscopic surgery will take part. The goal is to lower the risk of heart damage, a common…

This study is for people with early-stage liver cancer who are scheduled for surgery. Researchers are using an artificial intelligence tool to analyze each patient's scans and health data to predict their personal risk of the cancer returning. Patients identified as high-risk wil…

This early-stage study tests a new treatment called KD01, a modified virus that targets and kills bladder cancer cells. It is given directly into the bladder through a catheter. The trial includes 29 people with different stages of bladder cancer, focusing on safety and how well …

This study looks at whether two different versions of Angong Niuhuang Pills can help people recover from an acute ischemic stroke. Researchers will enroll 100 adults aged 18-80 and follow them for 84 days to check brain function, gut health, and immune response. The goal is to se…

This early-stage trial tests a new treatment called NouvSoma001 for people with neuromyelitis optica spectrum disorders (NMOSD), a rare disease that attacks the nerves in the eyes and spinal cord. The treatment uses tiny particles from stem cells, given via a spinal injection, to…

This study tests a new treatment called AZD0120 (GC012F) in 12 adults with end-stage kidney disease who have high levels of antibodies that make it very hard to find a matching kidney donor. The treatment uses specially engineered immune cells (CAR-T) to target and reduce these a…

This study tests whether the drug telitacicept works better than the standard drug cyclophosphamide for lung scarring (interstitial lung disease) caused by lupus. About 100 adults with early lupus and lung changes on CT scans will take part. The main goal is to see if telitacicep…

This early-phase study is testing a new treatment called universal CAR-T cells (RD06-05) in up to 36 adults with relapsing or refractory multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, or autoimmune encephalitis. The therapy uses speciall…

This study looks at how well antibody-based medicines work for people with a rare nerve disease called neuromyelitis optica (NMO). About 200 adults in China will take part, and researchers will track relapses, disability, and side effects over time. The goal is to find safer and …

This early-stage study tests a new cell therapy called QH103 in up to 6 people with relapsed or hard-to-treat autoimmune diseases like multiple sclerosis and myasthenia gravis. The therapy uses specially engineered immune cells to target and calm the overactive immune system. The…

This phase 3 trial tests whether a new drug (QL1706) plus bevacizumab works better than standard chemotherapy for women with advanced ovarian clear cell carcinoma. About 226 women aged 18 to 74 with newly diagnosed stage IC-IV disease will be randomly assigned to receive either t…

This study tests a medicine called glycerol phenylbutyrate in 40 Chinese children with urea cycle disorders, rare genetic conditions that cause dangerous ammonia buildup. The goal is to see if the drug safely controls ammonia levels over 5 years. Participants must follow a strict…

This study tests whether a minimally invasive procedure that drains the brain clot using a clot-busting drug (tenecteplase) helps people recover better than standard medical care alone. About 768 adults with a moderate-sized brain hemorrhage will be randomly assigned to either th…

This early-phase study tests a single injection of a gene therapy called V001-BCMA for people with autoimmune diseases like lupus, vasculitis, and scleroderma that have not responded to standard treatments. The therapy targets BCMA, a protein on immune cells, to try to control th…

This early-phase study tests a new CAR-T cell treatment called CT1190B for people with B-cell non-Hodgkin lymphoma that has come back or not responded to standard therapy. The main goals are to find a safe dose and see how well the treatment works. About 27 adults aged 18-75 will…

This study is for people newly diagnosed with primary central nervous system lymphoma (PCNSL), a rare brain cancer. It tests a combination of four drugs (methotrexate, rituximab, sintilimab, and pirtobrutinib) to see if it works better than standard treatments. About 110 adults w…

This study tests if a 300mg dose of secukinumab is safe and effective for Chinese adults with active ankylosing spondylitis (AS), a type of arthritis that causes back pain and stiffness. Participants must have tried at least two NSAIDs without success and never used biologic drug…

This study aims to create an AI model that can analyze MRI scans to diagnose 48 different brain conditions, such as tumors, strokes, and infections. Researchers will collect data from 1,000 patients to train the AI and compare its accuracy to that of doctors. The goal is to impro…

This study is testing a new blood test that looks for tiny molecules called MicroRNA in people with breast cancer. The goal is to see if this test can accurately detect the disease. Researchers will compare results from 100 participants, including healthy volunteers, to measure h…

This study tests whether getting a flu vaccine after a heart attack can lower the risk of another heart attack, stroke, or death. About 6,620 adults who recently had a heart attack will receive either a flu shot or a placebo. Researchers will follow them for one year to see if th…

This study looks at whether adding a nerve block for pain (celiac plexus block) to standard first-line cancer therapy helps people with advanced bile duct or pancreatic cancer. About 103 participants will receive both treatments and be followed for up to 2 years. The goal is to s…

This study tests whether combining a painkiller called tegileridine with a nerve block can better control pain after lung surgery. About 118 adults having lung surgery will receive this combination. The goal is to reduce pain, lower the need for extra pain drugs, and help patient…

This study looks at whether acupuncture can ease chronic constipation. 72 adults with long-term constipation will get either manual acupuncture or electroacupuncture (with a mild electric current) three times a week for 12 weeks. The goal is to see which method increases the numb…

This study tests two different sleep medicines (remimazolam and ciprofol) in children aged 2-12 having their tonsils removed. The goal is to see which one causes fewer breathing issues like coughing, airway blockages, or low oxygen during and right after surgery. About 114 childr…

This study looks at how a common bowel-cleansing laxative (PEG) used before colonoscopy changes the gut bacteria in people who have had their gallbladder removed. Researchers will compare 10 people with prior gallbladder removal to 10 people with an intact gallbladder. Stool samp…

This study reviews past medical records of people with Familial Mediterranean Fever (FMF) to see how well different drugs control symptoms and how safe they are. Researchers will look at how much symptoms improve based on patient reports. The goal is to learn which treatments wor…

This study tests a new, non-invasive MRI technique to monitor kidney function after a transplant. Instead of relying on blood tests or invasive biopsies, the MRI measures blood flow and oxygen levels in the kidney. The goal is to detect early signs of rejection or damage, potenti…

This study is creating a detailed database of 800 liver cancer patients to track their full treatment journey and long-term outcomes. The goal is to better understand what treatments work best in real-world settings. Participants must be 18 or older with a confirmed liver cancer …

This study tests whether an AI model can accurately predict if early-stage liver cancer will come back within 2 years after surgery. Researchers will follow 353 patients who have surgery, using their medical data and scans to train and validate the AI. The goal is to identify hig…

This study looks at 1,500 colorectal cancer patients who had surgery to remove their tumor. Researchers will use artificial intelligence to analyze CT scans, tissue samples, and medical records to predict if the cancer will spread to the liver. The goal is to create a tool that h…

This study aims to find new biomarkers in blood, urine, and other samples that could help predict who is at risk for ischemic stroke and how the disease will progress. Researchers will compare 7,000 participants—including stroke patients and healthy volunteers—over four years usi…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung problems after delayed hip surgery in people aged 65 and older. About 40 participants will be assigned to one of the two anesthesia types. The goal is to help doctors choose the safer option f…

This study explores whether a new type of MRI can accurately measure fat and metabolism in the liver without needing a needle biopsy. Researchers will scan 500 people with fatty liver disease and compare the results to standard tests. The goal is to make diagnosis, monitoring, an…

This study is observing whether a pain-blocking injection given during chest surgery can lower the chance of serious problems like lung infections or breathing trouble afterward. About 500 adults having keyhole or robot-assisted chest surgery will take part. The goal is to see if…

This study is gathering information from 50,000 people with headaches to create a better system for diagnosing and treating them. Researchers will collect medical history, treatment data, and biological samples to understand different headache types. The goal is to help doctors m…

This study explores whether emotional distress, like anxiety or depression, impacts how well liver cancer patients respond to immunotherapy. Researchers will follow 651 newly diagnosed adults with liver cancer who are starting treatment. The goal is to see if those with emotional…

This study tests a computer model that uses CT scans, tissue images, and patient data to predict if colon cancer will spread to the liver within two years after surgery. Researchers will enroll 160 patients with stage I-III colorectal cancer who are having curative surgery. No ex…