Tongji Hospital

This study looks at whether giving a bone-strengthening drug (denosumab) early, along with standard immunotherapy, can prevent bone problems like fractures or spinal cord compression in people with liver cancer that has spread to the bones. About 50 adults aged 18 to 75 will be r…

This study tests whether combining lenvatinib (a targeted therapy) with a PD-1 inhibitor (immunotherapy) can shrink or slow advanced solid tumors that have a specific genetic change called 11q13 amplification. About 60 adults with various cancers (like esophageal, head and neck, …

This study looks at 364 adults with advanced liver cancer that cannot be removed by surgery. It compares two treatment combinations: one using a standard procedure called TACE plus two drugs, and another using a different procedure called HAIC plus the same two drugs. The goal is…

This study tests a traditional Chinese medicine called Calculus Bovis Sativus (CBS) in 300 people who have had a brain hemorrhage. CBS is made from bezoar ingredients and is thought to reduce inflammation and protect brain cells. The goal is to see if it improves recovery and red…

This study tests a new treatment called ACE1831 for people with moderate to severe lupus that hasn't responded to other therapies. ACE1831 uses immune cells from healthy donors to help control the disease. The study will check if the treatment is safe and if it can reduce lupus s…

This study tests whether a HUAWEI smartwatch with artificial intelligence can help people who had a heart attack monitor their health during home recovery. About 1,050 adults will either use the AI smartwatch, a regular smartwatch, or standard care for three months. The goal is t…

This study tests whether glimepiride, a standard diabetes medication, can reduce the risk of heart-related death, heart transplant, or worsening heart failure in people with type 2 diabetes and chronic heart failure. About 1,484 adults aged 18-80 will receive either glimepiride o…

This early-stage study tests a new cell therapy for adults with relapsed or treatment-resistant acute myeloid leukemia (AML). Participants receive a single infusion of specially engineered immune cells (CAR-ITNK cells) that target two proteins, CD70 and CLL1, on leukemia cells. T…

This study tests a new daily pill called ivarmacitinib for people with rheumatoid arthritis who did not get better with standard treatments. The drug works by blocking inflammation signals in the body. Researchers will check if it reduces joint pain and swelling after 12 weeks, a…

This study tests whether a deep learning model can identify which liver cancer patients benefit from immunotherapy (PD-1 inhibitors) after surgery to prevent the cancer from returning. About 300 adults who had their liver cancer completely removed will be followed to see if the A…

This study tests a new drug called firsekibart in 30 people with a type of systemic sclerosis (scleroderma) that affects the skin. The goal is to see if the drug can improve skin thickness and other symptoms. Participants will receive the drug and be compared to similar patients …

This study looks at people with liver cancer that has spread outside the liver. It tests whether surgically removing the main liver tumor, along with standard drug therapy, helps them live longer compared to drug therapy alone. About 280 adults aged 18-75 with a resectable liver …

This study compares remote robotic liver surgery to local robotic surgery in 148 adults with liver disease. Participants are randomly assigned to one type of surgery and followed for 42 days to check recovery and complications. The goal is to see if remote surgery is as safe and …

This study tests whether a combination of targeted therapy (RC48-ADC) and immunotherapy (toripalimab) plus radiation can help people with HER2-positive muscle-invasive bladder cancer avoid bladder removal. About 45 adults who have already had chemotherapy will receive the drug co…

This study tests a new combination of treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The treatment combines a procedure called TACE with three drugs: tislelizumab (immunotherapy),…

This early-phase study tests a new type of CAR-T cell therapy for people with B-cell acute lymphoblastic leukemia or non-Hodgkin lymphoma that has come back or not responded to treatment. Participants get one infusion of specially engineered immune cells and are followed for thre…

This study tests a combination of three drugs—firsekibart, tislelizumab, and lenvatinib—in 25 adults with advanced liver cancer that has a TP53 gene mutation and has not responded to previous immunotherapy. The goal is to see if the combination can shrink tumors and control the d…

This study looks at people with liver cancer that has spread to a few spots outside the liver. All participants first get a combination of two drugs (sintilimab and lenvatinib). Those whose cancer is controlled are then randomly assigned to either continue the drugs alone or also…

This study will test an artificial intelligence (AI) model that uses MRI scans to tell the difference between benign uterine fibroids and a rare but aggressive cancer called uterine sarcoma. Researchers will enroll 500 women who are scheduled for surgery or long-term follow-up. T…

This study is testing a new blood test that looks for specific genetic markers (GNB4 and Riplet gene methylation) to detect if liver cancer has come back after treatment. About 162 adults who have had or will have surgery, transplant, ablation, or chemoembolization for liver canc…

This study will test a new blood test that looks for DNA changes to detect ovarian cancer, especially in its early stages. Researchers will collect blood samples from 1000 women who have ovarian masses and are scheduled for surgery or biopsy. The goal is to see how well the test …

This early-stage study tests whether a Chinese herbal formula called TJAOA103 can safely ease genitourinary symptoms of menopause, such as vaginal dryness, itching, burning, pain during sex, and urinary issues. About 113 women aged 45 to 70 will take the herbal formula twice dail…

This study looks at whether removing the adenoids (and sometimes tonsils) can improve allergy symptoms in children aged 3 to 12 with allergic rhinitis. It compares surgery to standard medication, measuring symptom changes and local allergy markers over 6 months. The goal is to se…

This study will test whether a virtual reality (VR) mindfulness program can help patients feel less anxious and experience less pain during minimally invasive vascular surgery done under local anesthesia. About 160 adults will be randomly assigned to either receive the VR mindful…

This study looks at whether a drug called osellidine can control pain during hysteroscopic surgery better and with fewer side effects than standard painkillers. About 310 women having day surgery will be observed to compare pain relief, side effects like breathing problems or con…

This study looks back at the medical records of 600 women with advanced ovarian cancer who took PARP inhibitor drugs after initial treatment. Researchers want to see if those who ate a low-carb diet had better survival than those who ate a regular diet. No special diet is given—p…

This study will test a computer model that predicts infertility risk in women with uterine fibroids. Researchers will follow over 7,000 women aged 20-50 who want to conceive and have fibroids. The goal is to see how well the model works and improve it, so doctors can better ident…

This study looks for biological markers that can predict bladder injury caused by radiation therapy. Researchers will collect samples from 220 adults who receive high-dose abdominal radiation. The goal is to create a model that helps doctors identify patients at risk for bladder …

This study looks for biological markers that can predict radiation-induced intestinal injury in people receiving high-dose abdominal radiation. Researchers will collect samples from 220 adults to build a model that forecasts this side effect. The goal is to improve early detectio…

This study looks at whether a blood test that detects tiny bits of tumor DNA (called minimal residual disease) can predict if liver cancer will come back after surgery. Researchers will follow 276 patients who had their liver cancer removed and test their blood over time. The goa…

This study will follow 1550 adults diagnosed with various neurological autoimmune diseases (like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis) to see how these conditions progress and respond to treatments in everyday medical practice. Unlike controlled drug…

This study looks at how different surgical tools used during lung cancer surgery affect coughing after the operation. About 248 adults having lung surgery will be randomly assigned to receive either energy-based or mechanical cutting tools. The goal is to find out which tool caus…