Stanford University

This study tests whether giving three drugs (gemcitabine, docetaxel, and toripalimab) before standard radiation can safely and effectively treat a specific type of nasopharyngeal cancer caused by the Epstein-Barr virus. About 24 adults with advanced but non-spread cancer will rec…

This early-phase study tests whether giving a radioactive drug (Lutathera) both before and after surgery is safe and feasible for people with metastatic neuroendocrine tumors of the gut or pancreas. About 10 adults with slow-growing tumors that have spread to lymph nodes or liver…

This study tests whether injecting a man's own platelet-rich plasma (PRP) into his testicles can help him produce sperm. It includes 10 men who have already had a failed sperm retrieval procedure. If successful, this could offer a new option for couples trying to conceive.

This early-phase study tests niclosamide, a drug currently used for worm infections, combined with standard chemotherapy in children whose acute myeloid leukemia (AML) has returned or not responded to prior treatments. The main goal is to find a safe dose and check for side effec…

This early-phase study tests whether a second infusion of the CAR T-cell therapy axicabtagene ciloleucel (Axi-Cel) is safe for adults with aggressive non-Hodgkin lymphoma who are at high risk of the cancer returning after their first standard CAR T treatment. About 20 participant…

This early-phase study tests a new treatment called KYV-101 for people with progressive forms of multiple sclerosis (MS) that are not responding to standard therapies. The treatment uses a patient's own immune cells, modified to find and attack harmful B cells that may drive the …

This study aims to see if a patient-centered, team-based care model supported by technology can improve blood sugar control in adults with type 2 diabetes. About 120,000 participants from 16 health centers will be involved over up to 3 years. The main focus is reducing the number…

This study tests whether a gene therapy called BVEC can help prevent squamous cell carcinoma (a type of skin cancer) from returning after it is removed in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition that causes fragile, blistering skin.…

This study is for people with early-stage non-small cell lung cancer who have finished standard treatment. A blood test looks for tiny bits of cancer DNA (ctDNA) that might mean the cancer could come back. If the test is positive, participants get a drug called durvalumab to try …

This early-phase trial tests a new cell therapy called Orca-T in people with advanced blood cancers (like leukemia) who are getting a stem cell transplant from a partially matched donor. The goal is to see if Orca-T can reduce serious complications, such as graft-versus-host dise…

This study tests a combination of three immunotherapy drugs (relatlimab, nivolumab, and ipilimumab) in 60 people with melanoma that has spread to the brain. The goal is to see if the treatment can shrink or stabilize brain tumors for at least 6 months. Participants may have sympt…

This early-phase trial tests whether statins, a common cholesterol medicine, can prevent strictures (narrowing of the bowel) in adults with Crohn's disease. About 20 participants will take either statins or a placebo daily for 6-12 months. Researchers will check colonoscopy resul…

This study tests the Cardiohelp device, a heart-lung machine, in up to 50 children with severe heart failure to see if it is safe and effective for up to 30 days. It also compares two blood thinners, heparin and bivalirudin, to find which causes fewer bleeding or clotting problem…

This early-phase trial tests a new treatment for adults with recurrent glioblastoma, an aggressive brain cancer. Doctors take a patient's own immune cells, modify them to recognize and attack cancer cells, and deliver them directly into the brain. The main goals are to see if the…

This early-phase trial tests a new approach for people with advanced blood cancers who are getting a stem cell transplant. Instead of using strong drugs to prevent graft-versus-host disease (a common complication where donor cells attack the patient), researchers will give specia…

This study looks at whether giving hospitalized diabetes patients who have trouble getting enough food access to free meals and nutrition education can reduce food insecurity and improve health. About 160 adults with type 1 or type 2 diabetes will be randomly assigned to receive …

This early-phase trial tests a personalized cell therapy called B7-H3 CAR T cells in 48 adults with ovarian cancer that returned after platinum chemotherapy. The treatment involves taking a patient's own immune cells, modifying them to better recognize and attack cancer, then inf…

This study tests a second type of CAR T-cell therapy (CD22 CAR T) for children and young adults whose B-cell leukemia came back after standard CD19 CAR T treatment. About 20 participants will receive the new cells 28 to 42 days after the first therapy. The main goals are to check…

This early-stage study tests a drug called efgartigimod in 5 adults with IgG4-related disease, a condition that causes swelling in glands and organs. Participants receive weekly injections for 12 weeks to see if the drug reduces swelling in the tear glands, saliva glands, or panc…

This study compares two surgeries for Fuchs endothelial dystrophy, a condition that clouds the cornea. One group gets a standard corneal transplant (DMEK), the other gets a newer procedure that strips damaged cells and uses Ripasudil eye drops to help healing. 60 adults will be f…

This early-stage trial tests whether specially engineered immune cells (GD2CART) can be safely made and given to children and adults with a rare, aggressive brain or spinal cord tumor called H3K27M-mutant diffuse midline glioma. The study aims to see if the cells can be produced …

This study tests whether giving radiation before surgery can completely eliminate ductal carcinoma in situ (DCIS), a very early form of breast cancer. Half of the 50 participants will have surgery right away, while the other half will receive radiation first and then have surgery…

This study tests whether extra support, including motivational interviewing and guided opioid tapering, can help people who have been on long-term opioids safely stop or reduce them after spine surgery. Some participants also receive a muscle relaxant (tizanidine) or a placebo. T…

This study tests whether a daily ergothioneine supplement can restore low levels of this nutrient in people with kidney failure who are on dialysis. Dialysis removes waste but also depletes helpful substances like ergothioneine. Researchers will measure blood levels before and af…

This early-stage trial tests a new treatment for children and young adults with medulloblastoma or similar brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified to recognize and attack a protein called G…

This study tests a special dye that attaches to lung cancer cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove all cancer tissue more accurately. About 30 adults with lung cancer or lung metastases will receive the dye before thei…

This study tests a special dye that attaches to brain tumor cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove more tumor tissue while sparing healthy brain. About 46 adults with malignant glioma or vestibular schwannoma will rece…

This study tests a special dye that makes brain tumor cells glow during surgery, helping surgeons remove more of the tumor safely. About 12 children and young adults (ages 6 months to 25 years) with suspected brain tumors will receive the dye before their planned surgery. The mai…

This study tests a low-risk surgical procedure called LYMPHA, done at the same time as breast cancer lymph node removal, to see if it can prevent lymphedema—a chronic, painful arm swelling. About 80 adults aged 18-75 undergoing breast cancer surgery will be randomly assigned to r…

This study tests if people with knee osteoarthritis can learn to change how they use a calf muscle while walking to reduce stress on the knee. Participants get gentle buzzes as feedback after each step to help them adjust. The goal is to see if this new walking pattern can lower …

This study tests whether N-acetylcysteine (NAC), a nutritional supplement, can reduce repetitive behaviors in children with autism. About 144 children aged 3 to 12 will receive either NAC or a placebo for 12 weeks. Researchers will measure changes in behavior and brain activity t…

This study tests whether zolpidem, a sleep medication, can improve sleep in children and teens with autism. About 26 participants aged 8 to 17 will receive either the drug or a placebo, then switch after a period. The goal is to see if the drug helps them fall asleep faster and s…

This study tests whether adding fermented foods like yogurt, kimchi, and sauerkraut to the diet can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. About 21 adults with confirmed UC will eat fermented foods for a period while re…

This study tests whether a 16-week therapy program for autism (Pivotal Response Treatment) works better when done at a center or at home. It includes 120 young children (ages 2-5) with autism and significant language delays. The goal is to see which setting helps improve social c…

This study tests whether a rapid, non-invasive brain stimulation technique can reduce hoarding symptoms. Ten adults with hoarding disorder will receive the treatment and be monitored for changes in their urge to acquire and keep possessions. The goal is to see if this safe, outpa…

This study compares a new multi-branched drain system (Interi) to standard drains in women having implant-based breast reconstruction after mastectomy. The goal is to see if the new drain reduces complications, shortens drain time, and improves patient comfort. About 20 women wil…

This study tests whether guanfacine, a medication typically used for blood pressure, can improve brain function and reduce depressive symptoms. Researchers will enroll 162 adults with depression to see if the drug helps with thinking problems and leads to remission. The goal is t…

This study explores whether virtual reality (VR) field trips can help hospitalized children feel more joy and awe. About 100 kids aged 5 to 17 will use VR to visit famous wonders of the world, combined with hands-on activities at their bedside. Researchers will measure changes in…

This study tests whether virtual reality (VR) can make physical therapy more effective for children and young adults with cancer who are staying in the hospital. Forty participants, ages 10 to 25, will try both VR-assisted and traditional physical therapy to see which helps them …

This study tests a telehealth program that teaches parents how to help their autistic children who strongly need things to stay the same. The program is adapted from an existing anxiety treatment and delivered entirely online. Researchers will see if parents can learn the techniq…

This study tests whether a smartphone app that uses brain scan feedback can help people with mild to moderate depression. About 240 adults will use the app to learn how to boost positive emotions. The goal is to see if this approach is safe and can reduce depression symptoms, pav…

This pilot study tests a non-invasive 3D-printed external penile device for men with moderate to severe erectile dysfunction from any cause. Nine men and their female partners will try the device during intercourse. The goal is to see if it is safe and improves erectile function,…

This study compares local anesthesia (with sedation) to general anesthesia for 1-3 level lumbar decompression surgery in people with lumbar spinal stenosis. Researchers want to see if local anesthesia works as well and leads to better pain and disability outcomes. About 100 adult…

This study tests a new type of spinal cord stimulation for people with long-lasting pelvic pain that hasn't improved with other treatments. The device automatically adjusts its energy output based on real-time feedback. Researchers will measure pain levels, disability, and qualit…

This study compares the Gokhale Method (a posture therapy) with standard physical therapy for people with chronic lower back pain. About 100 adults aged 18-65 with moderate to severe pain will participate. Researchers want to see which approach reduces pain and improves daily fun…

This pilot study from Stanford University aims to find out whether receiving brain stimulation (rTMS) in the morning or evening works better for treating insomnia. Ten adults with insomnia will receive ten sessions over two weeks. Researchers will track sleep quality and brain ac…

This study tests whether having a dream while under anesthesia can reduce symptoms of PTSD. About 42 adults with PTSD will be randomly assigned to either deep sedation (to encourage dreaming) or light sedation (to avoid dreaming). Researchers will compare changes in PTSD severity…

This study tests two early interventions—Written Exposure Therapy and Capnometry Guided Breathing—to reduce PTSD symptoms in women after childbirth. About 70 women who had a traumatic birth or whose baby was in the NICU will be assigned to one of these treatments or usual care. T…

This early-stage trial tests whether insulin eye drops are safe for people with glaucoma and other optic nerve diseases. About 52 participants will use the drops for 1-2 months while researchers monitor side effects and check for any changes in eye structure or vision. The goal i…

This study tests whether using a virtual reality (VR) headset during behavioral activation therapy can help older adults (65+) with major depression feel better. Researchers want to see if VR makes the therapy more engaging and effective. The study involves 30 participants and fo…

This study tests whether a cardiac rehabilitation program helps adults with Fontan failure walk more each day, improve exercise ability, and feel less frail. Fifty participants will either join the rehab program or receive usual care. The goal is to see if rehab can improve daily…

This study tests a new device called the Blossom Smart Expander for women undergoing breast reconstruction or augmentation. Instead of weekly needle injections to slowly stretch the skin, this device automatically and gently adds saline based on the body's own pressure. The goal …

This study tests a non-invasive device that uses radiofrequency energy to treat chronic nerve pain after injury or surgery. About 95 adults with nerve pain will receive the treatment to see if it reduces pain. The device is already FDA-approved for other uses, and the goal is to …

This study tests a smart system that reads facial expressions to see if older adults are truly engaged during computer-based brain training. The goal is to keep people motivated and improve their thinking skills, especially those at risk for Alzheimer's disease. About 80 adults a…

This study looks at whether children with narcolepsy type 1 prefer a new extended-release sodium oxybate taken once at night over the current non-extended-release versions. About 36 children will try both types and report which they like better. The study also checks safety, conv…

This study tests a mobile app that gives women with overactive bladder personalized tips and tools to manage their symptoms. The goal is to make treatment easier to access and stick with. About 30 women will use the app for 12 weeks to see if it improves their bladder health know…

This study looks at whether a treatment called DTPA chelation can reduce symptoms of Gadolinium Deposition Disease (GDD), a condition caused by gadolinium from MRI contrast dyes staying in the body. About 50 adults with GDD will receive at least 5 treatment sessions over two days…

This study tests a new group therapy program called BEAR (Building Empowerment and Resilience) for women aged 18-75 who have experienced interpersonal trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self…

This study compares two online treatments for chronic pain: an 8-week cognitive behavioral therapy program (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which one works better for reducing pain intensity and helping people get back to dail…

This study compares two methods of delivering pain medicine through a nerve block after surgery: a continuous slow drip versus scheduled small doses. The goal is to see which approach provides better pain relief and reduces the need for strong opioid painkillers. The study will e…

This study looks at whether embryos that were flagged as abnormal by genetic testing can still result in healthy babies. Researchers will track 300 participants who choose to transfer these embryos, monitoring pregnancy rates, birth outcomes, and children's health up to age 5. Th…

This study uses a non-invasive brain stimulation technique called TMS to see if it can change brain activity in people with schizophrenia. Researchers will measure brain waves before and after stimulation to learn how the hippocampus, a key brain region, is affected. The goal is …

This study uses surveys and interviews to learn how COVID-19 impacts cancer patients. About 50 adults with cancer will share their experiences over 12 months. No treatment is given; the goal is to gather information to better understand and support this group.

This study is a registry that collects contact and basic health information from people interested in joining future clinical trials for allergies or asthma. No treatment or experimental therapy is given. The goal is to build a list of potential volunteers so researchers can quic…

This study will develop a simple index to measure how well the body uses insulin and overall heart and metabolic health in children and teens with obesity. Researchers will use data from wearable devices like fitness trackers and glucose monitors, along with lab tests, to underst…

This study looks at whether analyzing the DNA of a patient's tumor can help doctors recommend more effective treatments. It involves 100 adults with advanced solid tumors that have spread or are hard to treat. The goal is to see if this personalized approach is practical and lead…

This study tests a web-based program called Partners Connect for military couples where one partner drinks too much. The goal is to see if the program helps the drinking partner cut back and encourages the service member to seek help. About 744 couples will participate, and resea…

This study is creating a web-based tool for romantic partners who are worried about their partner's drinking. Researchers will collect data from 275 couples to understand how partners can best communicate and support change. The goal is to improve the drinker's habits, the concer…

This observational study at Stanford University looks at whether the amount of carotenoids (natural pigments) in your skin is linked to how your immune system ages. Researchers will measure skin carotenoid levels and compare them to signs of skin aging, blood markers of aging, an…

This study compares different computer programs that analyze heart signals and images from people with atrial fibrillation (AFib). Researchers want to see which algorithms best identify the areas causing the irregular heartbeat. About 1,000 adults who are already scheduled for AF…

This study looks at how statin therapy changes bile acids and gut bacteria in people with primary sclerosing cholangitis (PSC), a liver disease with no cure. Researchers will collect samples from 15 adults with PSC to understand the disease better. The goal is not to treat PSC di…

This study at Stanford University uses machine learning to better understand different types of atrial fibrillation (AF), a common heart rhythm problem that can cause dizziness, stroke, and death. Researchers will collect data from 120 adults undergoing a heart procedure called a…

This study tests two experimental insulin formulas to see if they work faster than a standard insulin in adults with type 1 diabetes. Twenty participants will receive each insulin during three separate visits, and blood samples will track how quickly the insulin enters the bloods…

This study is for people with triple-negative breast cancer who still have signs of cancer after standard chemotherapy. Researchers will use a simple blood test (liquid biopsy) to look for tumor DNA and see if it can tell who will benefit from the drug capecitabine. The goal is t…

This study tests whether trained community health workers (Promotores de Salud) can help Latino/a adults better connect with mental health services. About 192 participants will attend six educational sessions to learn about mental health, reduce stigma, and improve coping skills.…

This study looks at whether ultra-processed foods (like sugary drinks and snacks) activate reward and memory areas in the brain more than minimally processed foods. Researchers will scan the brains of 162 teens aged 13–15 while they taste and view different foods. The goal is to …

This study looks at how a 12-week exercise program (cardiac rehab) changes thousands of proteins in the blood of people with heart failure. Researchers want to find which proteins improve symptoms, so they can later develop medicines that mimic exercise's benefits. About 90 adult…

This study looks at 100 adults having total shoulder replacement to compare a standard repair of a key shoulder muscle with a repair using a special material called Biobrace. The main goal is to see if ultrasound images show differences in how the muscle heals. Researchers will a…

This study from Stanford University looks at why people's blood sugar levels react differently to the same foods. Using continuous glucose monitors, researchers will track 100 healthy adults, people with prediabetes, and those with type 2 diabetes after eating specific meals. The…

This study looks at how the flu vaccine protects people who have had COVID-19, including those with long-term symptoms like fatigue or diabetes. Researchers will compare immune responses between 230 adults and children (ages 9-64) who had COVID-19 and those who did not. The goal …

This study collects tumor tissue from people with Hodgkin's or non-Hodgkin's lymphoma to learn more about the molecular and cell biology of their cancer cells. Participants must already be scheduled for a routine procedure to remove lymph nodes or other tissue. No new treatment i…

This study collects tissue and blood samples from people with stomach or esophageal cancer, as well as those at high inherited risk, to learn how genes and proteins contribute to these cancers. Researchers aim to better understand the disease, not to test a new treatment. About 1…

This study compares two types of pain medications (anti-convulsants and anti-depressants) in 450 adults with chronic pain. Unlike typical trials, it includes patients with other health problems to get results that apply to more people. The goal is to see which drug works better a…

This study tests whether a motion-capture system (like the kind used in video games) can make physical therapy more engaging for hospitalized children. Researchers want to see if it's easy for kids aged 6-17 to use and if it helps them move more while in the hospital. The goal is…

This study aims to learn more about the genes and proteins that cause head and neck cancer to grow and spread. Researchers at Stanford University will study tissue samples from 500 patients undergoing surgery for this cancer. The goal is to find new ways to diagnose and treat the…

This study looks at how a single dose of N-acetylcysteine (NAC), a well-tolerated supplement, changes brain chemicals in children with autism who have repetitive behaviors. About 24 children aged 3 to 12 will have brain scans and EEGs before and after taking NAC. The goal is to u…

This study aims to understand how repetitive brain stimulation (TMS) changes brain activity. Researchers will record brain signals from 49 adults with epilepsy who already have electrodes implanted for their medical care. The goal is to find reliable markers of TMS effects, which…

This study aims to learn more about the cells and molecules found in a gentle wash of the uterus (uterine lavage) collected from 50 women during gynecologic surgery. Researchers will analyze the samples to see what types of cells are present and look for genetic or protein marker…

This study looks at children and young adults (up to age 26) with B-cell leukemia or lymphoma who have received immunotherapy drugs like blinatumomab or Kymriah. Researchers will collect information on survival, remission, and any unmet needs through surveys. The goal is to bette…

This study tests whether data from smartphones and smartwatches can help identify teens and young adults with cancer who are struggling emotionally. About 25 participants aged 10-25 will use an app and wearable for two months. The goal is to speed up access to mental health servi…

This study aims to learn more about oropharyngeal carcinoma, a type of throat cancer, and its link to HPV. Researchers will collect blood samples from 1000 patients before treatment and at six follow-up visits. Tumor samples may also be taken when available. The goal is to better…

This study is a large registry that will follow 5,000 adults who receive or remove an IVC filter—a device placed in a large vein to prevent blood clots from traveling to the lungs. Researchers will review medical records to see how patients fare over the long term. The goal is to…