Could a blood pressure drug lift brain fog in depression?

NCT ID NCT06408246

Recruiting now Symptom relief Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jan 11, 2026 · Last updated Jun 16, 2026 · Updated 24 times

Summary

This study tests whether guanfacine, a medication typically used for blood pressure, can improve brain network function and reduce cognitive problems in people with depression. Researchers will enroll 162 adults aged 18-60 who are currently experiencing a major depressive episode. The goal is to see if the drug helps relieve depressive symptoms and improves daily functioning and quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Stanford Psychiatry and Behavioral Sciences Department
RECRUITING

Palo Alto, California, 94305, United States
University of Illinois at Chicago
RECRUITING

Chicago, Illinois, 60607, United States

Contact

Contact

Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder Neurobehavioral Manifestations

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION