PTSD

This study aims to reduce suicidal thoughts and behaviors in people with PTSD. Researchers are testing whether adding a crisis response plan to standard prolonged exposure therapy works better than therapy alone. About 100 adults with PTSD and suicidal thoughts will participate, …

This study tests a combined therapy for mothers with PTSD who are at risk of maltreating their children. About 160 mothers receiving preventive services will take part. The therapy blends emotional regulation skills with parent-child interaction coaching to reduce PTSD, depressio…

This study tests a program that combines PTSD treatment with weight management for Veterans who have both conditions. The goal is to see if this combined approach helps Veterans lose more weight and reduce PTSD symptoms better than standard care. About 182 Veterans will take part…

This study tests whether a brief form of exposure therapy, given soon after a serious injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 adults admitted to Level I trauma centers. Participants will be randomly assigned to receive the brief thera…

This study is testing two short videos designed to help teens and their parents cope after a traumatic injury. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. About 92 teens aged 12-17 and their parents will watch the videos and complete surveys ove…

This study tests whether treating PTSD symptoms can prevent acute pain (like from an injury) from becoming long-term chronic pain. Researchers will use either a nerve block procedure or talk therapy to reduce PTSD in 345 adults. The goal is to see if lowering PTSD symptoms helps …

This study tests a non-invasive device that gently stimulates the vagus nerve (a key nerve connecting the brain and body) in veterans who have both mild traumatic brain injury (mTBI) and PTSD. The goal is to see if it improves memory, reduces PTSD symptoms, and changes brain acti…

This study tests whether insulin given as a nasal spray can reduce symptoms of posttraumatic stress disorder (PTSD). Researchers will enroll 20 adults with current PTSD to see if the treatment lowers their symptom scores. The approach is experimental and aims to ease symptoms, no…

This study tests an online therapy program for people who have both PTSD and long-term pain. The goal is to see if it helps reduce PTSD symptoms and pain-related struggles. About 40 adults who speak Swedish and have stable medication will take part, with some starting the program…

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and complete assessments before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves bo…

This study tests whether adding extra support sessions to a standard mental health program helps refugees and asylum seekers feel less distressed and integrate better. About 1200 participants in Switzerland will receive the program, which is delivered by trained non-professionals…

This study is testing a new therapy that treats PTSD and chronic pain together in one program. It is for adults who have both conditions. The therapy includes 12 virtual sessions over six weeks, combining proven techniques for each condition. The goal is to see if this combined a…

This study looks at whether art therapy can improve emotional expression and regulation in military members with posttraumatic stress symptoms. About 40 active-duty or recently separated veterans will attend 11 sessions over 6-8 months, including art therapy, questionnaires, and …

This study is testing a psycho-education program for people who have experienced sexual violence. The goal is to see if the program can improve their quality of life, self-esteem, and mental well-being. The study will involve 60 participants who are already receiving care at a sp…

This study looks at whether a procedure called a cervical sympathetic block can reduce PTSD, anxiety, and other trauma-related symptoms in Special Operations Veterans. About 75 veterans will receive the block alone or with added therapy. The goal is to see if this approach provid…

This early-stage study tests whether psilocybin-assisted therapy in a group setting is safe and feasible for people with PTSD. About 36 adults, including veterans, first responders, female survivors of sexual violence, and Indigenous people, will receive the treatment. The goal i…

This early-stage study tests whether psilocybin mushrooms are safe for adults with PTSD and whether they might help ease symptoms. Up to 24 participants will eat dried mushrooms mixed into chocolate. The main goal is to check for side effects, but researchers will also look at ho…

This study tests a new, single-session therapy called PATH-SS for people who have experienced sexual assault. It aims to reduce symptoms of PTSD and depression. About 45 adults in Ohio will receive the therapy and be followed for one month to see if symptoms improve.

This study tests if a special type of yoga, called trauma-adapted yoga, can help teenagers with ADHD or PTSD. About 180 teens will either do yoga plus their usual care or just their usual care. Researchers will check if yoga improves symptoms like stress, focus, and pain.

This study tests whether adding memory-support techniques to standard PTSD therapy helps people learn and remember key therapy content. About 100 adults with PTSD will receive either standard therapy or therapy with extra memory aids. The goal is to see if better recall leads to …

This study tests a handheld device that sends gentle electrical pulses to the vagus nerve in the neck, which helps control stress. About 40 adults with PTSD will use the device at home daily for 12 weeks. Researchers will track symptom changes and safety to see if this approach c…

This study looks at whether a group therapy called Cognitive Processing Therapy (CPT) can help reduce PTSD symptoms and rule violations in incarcerated men and women. About 900 participants from six prisons will join the 24-week program. Researchers will measure changes in PTSD s…

This study tests whether adding augmented reality (AR) to standard exposure therapy helps U.S. military personnel with PTSD feel better. Forty veterans or active-duty members will be split into two groups: one gets AR-enhanced therapy, the other gets therapy alone. Researchers wi…

This pilot study looks at whether a telehealth program can help family members of ICU survivors cope with anxiety, depression, and PTSD. About 150 participants will use an online platform and have health check-ins. The goal is to see if this approach is practical and helpful for …

This study tests a 12-session workshop called STEP-Home-SP for veterans who left the military within the last three years. The workshop teaches skills to manage the transition, provides suicide prevention education, and helps connect veterans to VA care. The goal is to ease reint…

This study looks at ways to help veterans with PTSD who aren't getting better from their first treatment. Researchers will test switching to a different therapy and using text message reminders to encourage homework. The goal is to find the best approach for each person. About 30…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce PTSD symptoms in US Veterans. Fifteen participants will receive two guided psilocybin sessions. The goal is to see if this approach is safe and helps ease t…

This study tests which parts of therapy work best to help children aged 8-17 with post-traumatic stress disorder (PTSD) after a traumatic event. Researchers will compare different treatment components to a placebo to see what reduces symptoms most. Participants will attend weekly…

This study compares group-based MDMA-assisted therapy to individual sessions for people diagnosed with PTSD after the events of October 7, 2023. Researchers want to see if the group approach is as safe and effective as individual therapy. Participants will receive MDMA in a contr…

This study compares a new form of therapy for PTSD that mixes computer-guided exercises with therapist sessions to the current best treatment. About 160 adults with PTSD will receive either the new blended therapy or standard prolonged exposure therapy. The goal is to see if the …

This study tests a new group program called BEAR for women who have experienced trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Researchers want to see if it's possible to run this…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce PTSD symptoms in women who experienced sexual assault. About 70 women will receive the treatment in a supervised setting. The goal is to see if this approac…

This study tests a self-management program for people who have recently received a shock from their implantable defibrillator (ICD). The program includes heart rate monitoring and online lessons to reduce anxiety and prevent PTSD. 60 participants will be randomly assigned to the …

This study tests a drug called CORT108297 that blocks the stress hormone cortisol to help ease PTSD symptoms in veterans. About 40 veterans with PTSD will take the drug to see if it reduces their symptoms and is safe. The goal is to gather information for larger future studies.

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study tests whether having a dream while under anesthesia can reduce symptoms of PTSD. About 42 adults with PTSD will be randomly assigned to either deep sedation (to encourage dreaming) or light sedation (to avoid dreams). Researchers will compare changes in PTSD symptoms b…

This study tests a 12-16 week online program called Parenting STAIR for military-connected mothers who have experienced trauma and have young children ages 2-10. The program helps moms manage strong emotions from past stress and improve their parenting skills. Researchers will co…

This study looks at whether different levels of exercise (light, moderate, or high intensity) can help people with PTSD better remember safety cues after fear learning. 200 adults with PTSD will complete a 3-day brain imaging task and be randomly assigned to rest or 30 minutes of…

This study is testing whether a type of talk therapy called metacognitive therapy (MCT) can be delivered in a group setting for people with post-traumatic stress disorder (PTSD) in regular psychiatric care. The goal is to see if it is practical and acceptable to patients, and to …

This study tests if a simple injection of dextrose (sugar water) into the neck can reduce PTSD symptoms like anxiety, brain fog, and depression. About 24 adults who have tried at least two medications and two non-drug treatments for PTSD will receive either the injection or delay…

This study is creating and testing a short, virtual therapy program for LGBTQ+ people who have experienced trauma and use alcohol. In the first part, participants share their thoughts to make the program more helpful and inclusive. In the second part, some participants can try th…

This study compares two types of talk therapy for PTSD caused by military sexual trauma: exposure therapy and interpersonal therapy. About 208 survivors will receive one of the treatments to see if they are equally effective at reducing PTSD symptoms. The goal is to offer more ef…

This study tests a therapy called Targeted Cognitive Training (TCT) for 80 veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses computer exercises to improve how the brain processes sounds and information. Researchers will use EEG brain s…

This study tests whether a special thinking and attention training program works as well when done via video call as it does in person. It is for veterans who have both a mild traumatic brain injury and PTSD and struggle with focus and memory. The goal is to see if the program im…

This study tests a special sleep therapy (trauma-informed CBT for insomnia) in women veterans who have both PTSD and trouble sleeping. The goal is to see if improving sleep helps them feel more ready and willing to start PTSD treatment. About 100 women will be randomly assigned t…

This study tests a type of talk therapy called Trauma-Focused Psychodynamic Psychotherapy (TFPP) for veterans with PTSD who haven't gotten better with standard treatments. About 75 veterans will be randomly assigned to either TFPP or their usual care. The goal is to see if TFPP c…

This study is testing a digital therapeutic app called OTX-601 to see if it can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. About 40 people with PTSD will use the app, and researchers will track changes in their symptoms over 27 weeks. The goal is to find …

This study is testing whether a low dose of clonidine, a drug usually used for high blood pressure, can help veterans with PTSD sleep better and feel less stressed. About 32 veterans will take the drug for 6 weeks while researchers track changes in sleep quality, PTSD symptoms, a…

This study is testing whether a specific type of acupuncture can help reduce symptoms of post-traumatic stress disorder (PTSD) in 75 active-duty military members and their families. Participants will receive acupuncture and be monitored using standard PTSD questionnaires and bloo…

This study is testing whether a 12-week therapy program called ECCCLORE is practical and acceptable for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, stress, and relationships. Researchers will enroll …

This study tests a non-trauma psychotherapy for military veterans and service members who have both PTSD and a mild or moderate traumatic brain injury (TBI). The treatment involves individual talk therapy sessions to help manage PTSD symptoms. The study will enroll 30 participant…

This study tests a mental health support program for 150 people who recently left the ICU. The program includes digital tools, coaching, and psychiatric help to reduce anxiety, depression, and PTSD symptoms. Participants are compared to those receiving usual care over six months.

This study tests a faster way to diagnose and manage PTSD in primary care clinics on Chicago's South Side. Researchers will track how many people are screened, diagnosed, and treated for PTSD. The goal is to improve care for those affected by trauma.

This study looks at whether community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to see if this approach works in real-wo…

This study looks at how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will use a special imaging technique (PET/MRI) to measure changes in the arteries and bone marrow. The goal is to …

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake and aware while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departm…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study looks at whether a single dose of estradiol (a hormone) can lower the number of intrusive, unwanted memories after a traumatic experience. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The goal is …

This study looks at how a type of talk therapy for PTSD, called cognitive processing therapy (CPT), changes brain activity related to feeling pleasure. Researchers will use brain scans (fMRI) to see if therapy helps the brain's reward system work better. The study involves 120 ad…

This study compares two different screening methods for PTSD in 804 pregnant Black women. The goal is to see which approach better identifies PTSD symptoms, improves use of prenatal and mental health care, and leads to healthier births. Participants will be in their first trimest…

This study looks at how growing up with a heart condition can affect mental health, specifically post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults with congenital heart disease to find out what experiences (like painful surgeries or bullying) raise the r…

This study aims to understand the brain mechanisms behind fear and anxiety in people with PTSD or generalized anxiety disorder. Participants, who already have brain electrodes implanted for medical reasons, will do computer tasks and virtual reality exercises while their brain ac…

This study looks at whether exercise can affect how people with PTSD learn and remember emotional information. One hundred adults with PTSD from interpersonal violence will have MRI scans while recalling traumatic memories, then do either moderate or light exercise. The goal is t…

This study looks at whether a computer-based working memory training program can help veterans with PTSD better learn to unlearn fear. The training aims to improve the brain's ability to hold and use information, which may make fear extinction (a key part of PTSD recovery) more e…

This study looks at how a simple potato starch supplement changes gut bacteria in 30 veterans who have both cirrhosis (liver scarring) and PTSD. Researchers want to see if this natural fiber can improve the balance of good bacteria in the gut, which may help with brain health. Pa…

This study looks at how a non-invasive brain stimulation technique called TMS affects the brain's fear circuits. Researchers will test 250 people with and without PTSD to see how different TMS settings change brain activity and skin responses. The goal is to better understand how…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which brain networks improve. The goal is to find out how therapy works in the brain, which could…

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…