PTSD

This study tests whether a self-guided mobile app for cognitive behavioral therapy for insomnia (CBTI) can improve sleep and related issues like depression and PTSD in 144 active-duty service members. Participants use the app for five weeks, and researchers measure changes in sle…

This study tests whether a new drug, HB-1, can safely reduce PTSD symptoms compared to a placebo. About 200 adults aged 18 to 65 with PTSD will take the drug or placebo for 12 weeks. Researchers will measure symptom changes using a standard PTSD scale.

This study tests whether a single dose of COMP360, a lab-made version of psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely…

This study tests whether suvorexant, a medication already used for insomnia, can help Veterans with PTSD and sleep problems better overcome fear responses. About 40 Veterans will take the drug for 7 nights and undergo fear conditioning and extinction tests. The goal is to see if …

This study looks at how poor sleep affects warfighters with PTSD, traumatic brain injury, or chronic stress. It tests a smartwatch that vibrates gently when it detects a nightmare or stress surge during sleep. The goal is to see if this device can improve sleep quality, daytime f…

This study tests whether a 5-day accelerated form of transcranial magnetic stimulation (TMS) can reduce PTSD symptoms in veterans. About 90 veterans with chronic PTSD who still have symptoms despite current treatments will receive either real or sham TMS. The goal is to see if th…

This study tests whether adding a nerve block injection (stellate ganglion block) to standard talk therapy (cognitive processing therapy) can better reduce PTSD symptoms. 270 adults with PTSD will receive either the combination, talk therapy plus a placebo injection, or the injec…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with intensive talk therapy can help people with chronic post-traumatic stress disorder (PTSD). Fifteen adults with moderate to severe PTSD will receive the treatment and be m…

This study looks at whether cannabis can help veterans with PTSD manage symptoms like anxiety, depression, and suicidal thoughts. About 280 veterans who rarely use cannabis will receive it alongside standard talk therapy. The goal is to see if this combination improves mental hea…

This study tests whether a drug called psilocybin (found in certain mushrooms) combined with talk therapy can safely reduce PTSD symptoms. About 150 Georgia military veterans will be randomly assigned to one of two therapy approaches. The goal is to see if this combination is mor…

This study tests whether virtual reality (VR) can help people who feel traumatized after COVID-19. About 100 healthcare workers and COVID-19 survivors will use VR to safely face and process their stressful memories. The goal is to reduce PTSD, anxiety, and depression over 5 weeks…

This study tests if a simple injection of dextrose (sugar water) into the neck can reduce anxiety, brain fog, and depression in people with PTSD who haven't improved with standard treatments. Fifty adults who have tried at least two medications and two non-drug therapies will rec…

This study looks at stress and PTSD in Black teenage girls who have been involved with the justice system, along with their parents or caregivers. Researchers want to understand what helps or hinders these teens from using mindfulness-based stress reduction. The goal is to learn …

This study looks at why many veterans with PTSD do not start recommended talk therapies like CPT or PE. Researchers will track the treatments 40 veterans actually receive and use that information to design a program that helps veterans transition to these effective therapies fast…

This study follows 300 Ukrainian veterans with combat-related amputations to see if longer evacuation times and extended tourniquet use increase the risk of developing PTSD. Participants will be tracked for 18 months using PTSD symptom questionnaires. The goal is to identify key …

This study looks back at data from 80 veterans and first responders who completed a 12-week wellness program that combined therapy, exercise, and nutrition. Researchers will use wearable rings to track sleep and activity, along with surveys and interviews, to see how the program …

This study tests a gentle brain stimulation method called temporal interference (TI) in healthy volunteers and people with anxiety or PTSD. Researchers want to see if TI can change brain activity and reduce symptoms like worry, fear, and emotional distress. The study involves 300…

This study aims to find out which factors—like how flexible your thinking is, how much support you have, and your body's stress response—can predict if someone will develop PTSD after a major injury. Researchers will follow 250 adults treated in the emergency department for 6 mon…