PTSD

This study looks at whether adding cognitive behavioral therapy (a type of talk therapy) to standard medication can improve symptoms and daily functioning for people with conditions like anxiety, depression, OCD, PTSD, bipolar disorder, schizophrenia, and personality disorders. A…

This study looks at whether a therapy called RRFT, which treats both substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with trauma history and both conditions will be randomly assigned to RRFT or usual care. Rese…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter trainees. About 480 recruits will take part in either an emotion regulation workshop or a standard education session during their aca…

This study tests whether a single dose of MDMA, given during a 10-day intensive therapy program, can help ease PTSD symptoms. Forty adults with PTSD will receive the combination treatment at Emory University. The goal is to see if MDMA makes the therapy work better and faster.

This study looks at whether adding oxytocin (a natural hormone) to talk therapy helps veterans with both PTSD and alcohol use disorder. About 175 veterans will receive either oxytocin or a placebo along with therapy. The goal is to see if oxytocin reduces drinking and PTSD sympto…

This study tests a 15-session creative writing program called REWRITALIZE for people with severe mental illness, including schizophrenia and bipolar disorder. The program is led by a professional author and aims to improve personal recovery, thinking skills, and social connection…

This study looks at whether adding a special type of massage therapy to standard care helps refugees and asylum seekers who survived torture or war. About 50 people will either get standard care plus massage or standard care alone. The goal is to see if the massage reduces pain, …

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and adjusts based on each person's needs, aiming to reduce PTSD symptoms and the number of emergency room visits. About 424 pa…

This study looks at whether psilocybin, the active ingredient in magic mushrooms, can safely help veterans with PTSD. Fifteen U.S. military veterans aged 21-64 with PTSD will receive psilocybin alongside therapy. The goal is to see if it reduces PTSD symptoms and is safe to use.

This study tests whether stimulating a nerve in the ear or neck can improve sleep in veterans with PTSD. About 87 veterans with sleep problems will try two different stimulation locations. The goal is to find a better way to help people fall and stay asleep without relying on cur…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with PTSD. 234 adults will be randomly assigned to receive DBR or join a waitlist. Researchers will measure changes in PTSD symptoms using a standard scale to see if DBR helps.

This study looks at whether having a psychiatric service dog makes Prolonged Exposure Therapy work better for veterans with PTSD. About 216 veterans who already qualify for a service dog will take part. Researchers will measure PTSD symptoms using questionnaires and clinician int…

This study tests a short therapy called Brief Prolonged Exposure (Brief PE) to see if it can reduce post-traumatic stress in people who have had a spinal cord injury. About 200 adults in inpatient rehab will either get the therapy or standard care. The goal is to ease PTSD sympto…

This study tests a 12-session group therapy program for active duty military personnel who are having suicidal thoughts or have recently attempted suicide. The therapy teaches coping skills and emotion regulation to reduce suicide risk. Researchers will compare it to a standard t…

This study compares two virtual treatments for PTSD: a 1-week intensive Cognitive Processing Therapy (CPT) and a 5-day relaxation training. About 140 adults with PTSD will participate to see which approach better reduces symptoms and to understand how the treatments work. The goa…

This study uses brain imaging to explore how cannabis affects inflammation and brain activity in U.S. military veterans with PTSD. Up to 100 veterans will have brain scans before and after 12 weeks of cannabis treatment. The goal is to link brain changes to improvements in PTSD s…

This study aimed to see if holistic education could help people manage stress and related conditions like anxiety, fatigue, and PTSD. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who agreed to a smoke-free, drug-free, and alcohol-free lifestyle. The …

This study looks at 65 veterans with PTSD who use cannabis heavily. Researchers want to see if reducing cannabis use improves daily functioning, mental health, and quality of life. No treatment or drug is given—just observation and surveys over time.

This study looks at whether doing therapy in the morning or late afternoon changes how well people with PTSD overcome fear. 52 adults will receive 10 sessions of prolonged exposure therapy via telemedicine, either right after waking or after 4 PM. Researchers will measure fear re…

This study looks at how people learn fear and safety by using virtual reality. Researchers will measure brain activity, heart rate, and sweat responses in 70 adults who already have a brain implant for epilepsy. The goal is to better understand anxiety and PTSD, which could lead …

This early-stage study tests whether a drug called brexanolone is safe and practical for people who have both posttraumatic stress disorder (PTSD) and alcohol use disorder. Researchers will give the drug to 25 adults aged 21-55 and watch for side effects. The goal is to gather in…

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. The researchers will compare a team-based problem-solving approach (Participatory S…