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Could a nasal spray of insulin help PTSD?

NCT ID NCT04044534

First seen Oct 31, 2025 · Last updated Jun 19, 2026 · Updated 21 times

Summary

This Phase 2 trial tests whether a daily nasal spray of insulin can reduce PTSD symptoms in 20 adults aged 21-65 with current PTSD. Participants receive either intranasal insulin or a placebo for a set period. The main goal is to see if symptoms improve, measured by a standard PTSD scale.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • VA Connecticut Healthcare System

    RECRUITING

    West Haven, Connecticut, 06516, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

intranasal insulin

What this could lead to

If it works, this could point toward a new way to ease PTSD symptoms using a familiar drug.

What could go wrong

This is a very small early-stage trial with only 20 people, so results may not apply broadly. It is testing symptom relief, not a cure.

Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.