PNEUMONIA

This study looks at how well a 20-valent pneumococcal vaccine works against pneumonia in adults aged 65 and older who are hospitalized with the infection. Participants provide a urine sample and medical history, and researchers compare vaccination rates between those with vaccine…

This study tests an investigational drug called AV-001 in people hospitalized with pneumonia caused by COVID-19 or other respiratory infections. The goal is to see if AV-001 is safe and helps patients recover faster when added to standard care. About 120 participants will receive…

This study looks at whether using higher pressure during noninvasive breathing support (a mask that helps you breathe) can help people with pneumonia or acute lung injury avoid needing a breathing tube. About 700 adults will be randomly assigned to either high or low pressure. Th…

This study looks at whether some children with mild pneumonia can recover without antibiotics. About 700 kids aged 6 months to 18 years who visit the emergency room with pneumonia but are well enough to go home will take part. Doctors will compare standard antibiotic treatment ag…

This study looks at whether children with medical complexity who have pneumonia can safely stop antibiotics earlier, based on when they become clinically stable. Researchers will enroll 50 patients aged 2-25 at Boston Children's Hospital. The goal is to reduce unnecessary antibio…

This large study tests many treatments, including drugs for COVID-19 and flu, to see which ones help prevent death in people hospitalized with pneumonia. About 70,000 participants are involved. The goal is to find effective therapies to improve survival and speed up recovery.

This study tests whether a special blood filter called oXiris works better than the standard M100 filter for people with pneumonia who also develop acute kidney injury. About 60 adults will be randomly assigned to one filter during continuous blood cleaning (CRRT). Researchers wi…

This study looks at whether adding a gentle brain stimulation technique (rTMS) to standard swallowing therapy can lower the chance of pneumonia in people who have trouble swallowing after a stroke. About 70 adults with moderate to severe swallowing issues will take part. The goal…

This study looks at whether low-intensity laser therapy can improve the immune response in children with Down syndrome who have pneumonia. Forty children will receive either laser therapy plus breathing exercises and standard medical care, or just breathing exercises and standard…

This study tests a new ventilator (INBENTUS VERSATILE) in 81 adults who need help breathing due to conditions like pneumonia, ARDS, or COPD. Participants will use the ventilator for 3 to 48 hours, and researchers will monitor for side effects and how well the machine works. The g…

This study is testing a device called Inflammacheck that measures certain chemicals in a person's breath to see if it can help tell if someone has lung cancer. The goal is to create a simple, non-invasive tool that could be used in clinics to quickly decide who needs further test…

This study tests a new portable chest X-ray machine that takes moving images (15 frames per second) right at the bedside in the ICU. Researchers want to see if it gives doctors better information about lung and diaphragm function compared to standard X-rays. About 230 adults with…

This study checks whether standard devices that measure blood flow and fluid needs work correctly in patients on ECMO, a machine that pumps and oxygenates blood outside the body. About 30 adults with severe lung failure will be enrolled. The goal is to improve how doctors manage …

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases like COPD, pneumonia, and pneumothorax. Researchers will measure LSI in 700 adults with various lung conditions and healthy volu…

This study is working to create a better way to diagnose pneumonia in older adults (65+) who come to the emergency room. Researchers will observe 250 patients with suspected pneumonia and test if new biomarkers can improve accuracy. The goal is to help doctors quickly tell if it'…

This study checks how well standard ICU monitors measure blood flow and fluid needs in 30 adults on VA-ECMO, a machine that pumps and oxygenates blood outside the body. Researchers will compare three monitoring methods to see which works best during this special situation. The go…

This study tests whether improved oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with small to moderate brain bleeds will be randomly assigned to receive either standard care or enhanced mouth care plus ant…

This study tests whether adding a special breathing treatment called intrapulmonary percussive ventilation (IPV) to standard care helps people with pneumonia who are on a breathing machine. About 96 adults will be randomly assigned to receive either standard care alone or standar…

This study tests whether breathing high doses of nitric oxide gas can help critically ill pneumonia patients on ventilators recover. About 34 adults will receive either the gas or a placebo for 5 days, and researchers will monitor safety and cure rates. The goal is to see if this…

This study tests whether exposure to bright blue light can reduce inflammation and organ damage in people hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. About 144 adults will be randomly assigned to receive either blue-enriched ligh…

This study tests a personalized approach to giving steroids to adults hospitalized with pneumonia. Instead of a one-size-fits-all dose, doctors will use a blood test (CRP) to decide the right amount and timing for each patient. The goal is to reduce steroid side effects while sti…

This study compares a combination of two sedatives (propofol and ketamine) against propofol alone in elderly ICU patients who need a breathing tube. The goal is to see if the combo reduces dangerous drops in blood pressure. About 41 patients aged 65 and older with heart disease a…

This study compares a new type of hospital care, called an Acute Medical Unit, to standard hospital care for older adults with sudden medical illnesses like infections or falls. Researchers want to see if this model reduces time spent in the hospital, improves quality of life, an…

This study follows people with Hyper IgE Syndrome (HIES), a rare immune disorder that causes severe eczema, lung infections, and other health problems. Researchers will track up to 600 participants and their relatives over time to learn how genetic changes cause the disease and h…

This study measures three blood markers (GDF-15, MR proADM, and Presepsin) in 60 men under 65 who have acute coronary syndrome, pneumonia, and COPD, and have received an influenza vaccine. The goal is to see if these markers relate to the patients' health and how the vaccine affe…

This study looks back at the medical records of 350 adults in France who had surgery for esophageal cancer between 2017 and 2024. The goal is to understand how often infections like pneumonia happen after this surgery, what factors increase the risk, and how these infections affe…

This study looks at proteins in lung fluid from people with pneumonia to find out what is causing their lung inflammation. Researchers hope to discover protein patterns that can help doctors diagnose different types of pneumonia more accurately. About 750 patients already schedul…

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how well the body absorbs the new tablet compared to the original version, and whether taking it with food or as a drink changes absorption.…

This study is observing 800 adults admitted to the respiratory ICU with severe pneumonia. Researchers will track symptoms, breathing support needs, and death rates to better understand the disease. No new treatments are being tested; the goal is to gather information to improve f…

This study tests whether a common substance, sodium bicarbonate (baking soda), can be used as a safe contrast agent to create images of lung blood flow using a bedside imaging method called electrical impedance tomography (EIT). About 41 adults on breathing machines in the ICU wi…

This study looks at whether a therapy called OLE (Oscillatory Lung Expansion) helps ICU patients with pneumonia clear mucus from their lungs. Researchers will use a special imaging technique called EIT to see how the lungs respond. The study includes 62 adults in the ICU who prod…

This study looks at how well a drug combination called sulbactam-durlobactam works against hard-to-treat infections caused by a superbug called CRAB. About 200 hospitalized adults will be observed, and their outcomes will be compared to those receiving other treatments. The goal …

This study uses advanced genetic sequencing to monitor antibiotic resistance in 800 pneumonia patients. Researchers will compare the types of bacteria and resistance genes found in severe versus mild cases. The goal is to better understand how resistance spreads and to improve tr…

This study looks at how medical oxygen is provided in six countries in Africa and Asia. Researchers will interview policymakers, health workers, and others to find out what works and what doesn't. The goal is to improve oxygen access for people with breathing problems like pneumo…

This study tests whether computer alerts in the electronic health record can help doctors avoid prescribing antibiotics when they aren't needed for children with lower respiratory tract infections like pneumonia, bronchiolitis, or asthma flare-ups. Most of these infections are ca…

This study is collecting blood and other samples from 2,000 adults who come to the emergency room with a suspected respiratory infection. The goal is to build a biobank to better understand how different infections affect the body. Researchers hope this will lead to new ways to d…

This study uses a special type of MRI (called hyperpolarized xenon MRI) to look at lung function in adults who have had a bone marrow transplant and developed lung problems like bronchiolitis obliterans syndrome. Researchers want to see if this imaging can better measure how well…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study is observing 4,000 adults in intensive care with ARDS, sepsis, or pneumonia to identify different types of these illnesses. Researchers will collect medical information and samples to build a biobank for future studies. The goal is to improve understanding of risk fact…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than letting parents decide if one is needed. About 2,674 children hospitalized for infections like pneumonia or urinary tract infections will take part. The goal i…

This study looks at whether using lung ultrasound to diagnose pneumonia in children aged 3 to 10 can cut down on unnecessary antibiotic use. Currently, doctors often rely on exams and chest X-rays, which aren't always accurate. The goal is to see if ultrasound can guide better tr…