PNEUMONIA

This study checks how well the PCV20 vaccine prevents pneumonia and other lung infections in adults 18 and older who are at higher risk. Researchers will look at health records from over 800,000 people at Kaiser Permanente Southern California, comparing those who got the vaccine …

This study follows healthy pregnant women who previously received an experimental Group B Streptococcus (GBS) vaccine to see if their immune protection lasts. It also tests whether a booster dose given during a new pregnancy is safe and boosts immunity, aiming to protect newborns…

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to either a 5-day or 10-day course, with some receiving a placebo a…

This study tests whether a new DNA test (mNGS) can help doctors identify the bacteria or virus causing pneumonia faster than standard methods. About 114 ICU patients on breathing machines will be randomly assigned to get either the new test or usual care. The goal is to see if fa…

This study looks at whether a thin, flexible tube with a camera (bronchoscopy) can help find the exact germ causing pneumonia in children who are not getting better with standard antibiotics. About 58 children in the pediatric ICU will have this procedure to collect lung samples.…

This study tests whether a single, low-dose radiation treatment to the lungs can reduce inflammation in hospitalized adults with COVID-19 pneumonia. The goal is to see if this approach lowers the need for breathing machines and shortens hospital stays. About 37 participants will …

This study investigates why some antibiotics fail to reach the lungs in patients with pneumonia, even when blood levels are adequate. Researchers will measure antibiotic concentrations in lung fluid from 101 adults who are not responding to treatment. The goal is to identify fact…

This study looks at whether a new way of paying for healthcare, called bundled payments, improves quality and lowers costs. Researchers will analyze Medicare data from 440 provider organizations for common conditions like osteoarthritis and pneumonia. The goal is to see if this p…

This study looks at 1,800 adults in Hong Kong hospitals who have pneumonia. Researchers use a simple urine test to find out which types of pneumococcus bacteria are causing the infection. The goal is to learn which bacterial strains are most common, which can help improve vaccine…

This study looks at 100 adults hospitalized in intensive care with pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers track how patients are treated, how long they stay in the hospital, and whether the bacteria resist common antibiotics. The goal is to better under…

This study tracks 120 patients who receive a left ventricular assist device (LVAD), a mechanical heart pump. Researchers want to see how often infections happen after surgery and how the immune system changes. The goal is to find clues that could help predict and prevent infectio…

This study involves 40 hospitals to see if a customized antibiotic stewardship program reduces unnecessary antibiotic use when patients leave the hospital. It focuses on adults hospitalized with pneumonia or urinary tract infections. The approach is tailored to each hospital's ne…

This study aimed to see if quinine could be used as a marker to detect aspiration (leakage of fluids into the lungs) in critically ill patients on breathing machines. The plan was to collect samples from the mouth and windpipe to measure quinine levels. However, the study was wit…