PNEUMONIA

This study tested a new 23-valent pneumococcal polysaccharide vaccine in 144 healthy volunteers aged 2 years and older. Participants received one dose of either the experimental vaccine or a control vaccine. The main goal was to check safety and measure the immune response. The t…

This study checked how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia and related infections in adults with HIV. Researchers looked at health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The goal was to see i…

This study tested whether training local health workers in 80 remote Indian villages could lower death rates among adults aged 16-60. Over 72,000 people took part. The workers provided education, treatment, and referrals for conditions like high blood pressure, diarrhea, pneumoni…

This study tested a drug called Auxora in 314 people with severe COVID-19 pneumonia. The goal was to see if it could help them recover faster and reduce deaths. Participants received either Auxora or a placebo through an IV over 48 hours. The trial was completed and results are b…

This study tested two ways of using a breathing machine during heart surgery that requires a heart-lung machine. One group received no breaths during that time, while the other received small, gentle breaths. The goal was to see which approach better prevents serious lung complic…

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the pneumonia from becoming severe, requiring intensive breathing support or causing death. Participants re…

This study tested whether giving early treatment for cytomegalovirus (CMV) and tuberculosis (TB) can help HIV-infected infants with severe pneumonia survive. Over 500 babies under one year old were enrolled. The goal was to see if this approach reduces deaths in the short and lon…

This study tested ways to safely reduce unnecessary antibiotics in hospitalized patients with possible pneumonia who had normal breathing and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to shorte…

This study looked at whether giving children hospitalized with pneumonia a longer course of antibiotics (amoxicillin-clavulanic acid) leads to better recovery than a shorter course. Over 300 children aged 3 months to 5 years took part. The main goal was to see if longer treatment…

This study tested whether using lung ultrasound to guide how ventilated newborns are positioned can prevent ventilator-associated pneumonia. 80 full-term babies on breathing machines took part. The approach aims to reduce a common complication in intensive care.

This study looked at a new program called the Next Day Clinic (NDC) at UCLA. Instead of admitting certain patients from the emergency room to the hospital, the clinic sends them home and sees them the next day. The goal is to keep people out of the hospital when it's safe, improv…

This study tested a new way of using breathing machines for COVID-19 patients with severe lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. About 220 adults on ventil…

This study tested a new approach for people with severe COPD: using a simple blood test (eosinophil count) to decide when it's safe to reduce inhaled steroids and when to add an antibiotic (azithromycin). The goal was to lower the risk of flare-ups and hospital stays while avoidi…

This study tested whether using a low-dose CT scan or lung ultrasound is more accurate than a standard chest X-ray for diagnosing pneumonia in people over 65. About 473 older adults with suspected pneumonia in the emergency room took part. The goal was to see if better imaging co…

This study looked at whether lung ultrasound (LUS) can accurately diagnose pneumonia in children in low-resource settings, compared to chest X-ray. Researchers studied 320 children with suspected pneumonia. They found that LUS missed some cases, but the goal was to see how well i…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage 8 common health problems (like pneumonia, kidney stones, and pregnancy concerns) without needing extra tests. Over 160 patients took part, and researchers compar…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked safety, immune respons…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out which patients are more likely to board, how boarding increases healthc…

This study tested a rapid test (BioFire FA Pneumonia Panel) to quickly find the germ causing pneumonia in ICU patients on breathing machines. 40 adults were randomly assigned to get the rapid test or usual care. The goal was to see if the test helps doctors choose the right antib…

This study looked at how the antibiotic ceftobiprole spreads in the blood and lungs of 12 adults with severe pneumonia who needed a breathing machine. Researchers gave a high dose continuously for 24 hours and took blood and lung fluid samples to measure drug levels. The goal was…

This completed study used health records from 2 million French adults to see if people who had pneumonia are more likely to develop heart disease, stroke, or other cardiovascular problems later on. Researchers compared pneumonia survivors to similar people without pneumonia. The …

This study observed over 1,800 children hospitalized for serious breathing issues like bronchiolitis, pneumonia, or asthma. It aimed to track how many children under 12 months were hospitalized for bronchiolitis after a new immunization became available. The study did not test an…

This study looked at how different oxygen level goals and different oximeters (the clip-on devices that measure blood oxygen) affect the amount of oxygen given to patients. Researchers studied 40 adults with COPD or other breathing problems like pneumonia. They wanted to see if t…

This study looked back at 1,000 patients who needed extra tools to place a breathing tube during surgery. The goal was to see if these patients had a higher chance of breathing in stomach contents or developing pneumonia after the operation. The findings help doctors understand r…

This study looked at whether a tool called the ARISCAT score can predict lung complications (like pneumonia or collapsed lung) after major abdominal cancer surgery. Researchers followed 410 adults who had surgery under general anesthesia. The goal was to see if the score could he…

This study looked at whether a set of care guidelines could help community hospitals use proven treatments for children with asthma, pneumonia, or bronchiolitis. Over 11,000 children participated across multiple hospitals. The goal was to see if these guidelines increased the use…

This early-stage study tested the safety of a single inhaled dose of FLAMOD, a drug that activates the immune system, in 46 healthy adults. The goal was to find a safe dose that triggers local immune responses in the lungs. This research is a first step toward possibly using FLAM…

This study involved 300 adults with pneumonia to develop and test a simple scoring system called RESPIRE. The goal was to help doctors quickly identify if the infection is caused by multidrug-resistant bacteria. By using patient information available at the hospital, the score ai…

This study tested a new way to help doctors decide when antibiotics are needed for hospitalized patients with suspected pneumonia. An electronic alert guided testing to tell if the infection was viral or bacterial. Patients with viral results were randomly assigned to either rece…

This study aimed to find biological markers (biomarkers) in 272 pneumonia patients that could predict outcomes like death or worsening illness. Researchers measured things like mortality and whether the pneumonia became severe despite treatment. The goal was to better understand …

This study looked at medical records of 239 patients aged 65 and older who had major abdominal surgery. The goal was to find out what factors increase the chance of lung complications like pneumonia or breathing failure after surgery. By identifying these risks, doctors may be ab…

This study tested whether a special lung imaging technique called Electrical Impedance Tomography (EIT) can safely help doctors choose the right ventilator pressure for infants and toddlers under 3 years old. Fourteen children with various lung or breathing problems took part. Th…

This study looked at 179 ICU patients with pneumonia to figure out the best doses of common antibiotics. Researchers measured drug levels in the blood and lungs to create personalized dosing plans. The goal is to improve treatment success and reduce the risk of drug-resistant inf…

This study tested a program where rural hospitals connect with infection experts through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant germs. Eight VA medical centers took part, and researchers measured how often an…