PERIODONTAL DISEASES

This study tested whether using a calibrated interdental brush (sized to fit each gap) reduces gum bleeding better than a non-calibrated brush in 51 healthy young adults aged 18-30. Participants used one type of brush daily for three months. The main goal was to compare gum infla…

This study tested whether adding enamel matrix proteins (Emdogain) and a bovine bone graft to a minimally invasive gum surgery (M-MIST) helps heal deep gum defects better than surgery alone. Forty-five adults with at least one deep gum pocket were treated and followed. The main g…

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This study looked at whether using a piece of a patient's own tooth can help repair bone gaps around new dental implants placed right after a tooth is pulled. 63 adults aged 20 to 45 with a damaged front tooth were treated. Some got the standard implant, some got an extra tooth g…

This study tested whether a special bone graft material containing zinc, combined with a platelet-rich fibrin block, could help repair bone damage caused by gum disease. Thirty adults with gum disease received the treatment, and researchers measured gum health and bone healing. T…

This study tested whether taking antibiotics along with standard deep-cleaning treatment (scaling and root planing) improves gum health in adults with periodontitis. 236 participants from dental practices across the U.S. were randomly assigned to receive either antibiotics (amoxi…

This study looked at whether using a 980nm diode laser along with standard deep cleaning improves gum health and reduces body-wide inflammation in people with gum disease, both those who have had a heart attack and those who haven't. About 80 participants under 70 years old were …

This study tested a special gum surgery technique (EPPT) alone or combined with enamel matrix derivative and a bone graft material to treat bone defects caused by gum disease. Fifty-eight adults with moderate to advanced gum disease participated. The goal was to see if the combin…

This study tested whether a probiotic called TCI188 (Pediococcus acidilactici) can improve oral health in adults with severe gum disease. 55 participants took the probiotic, and researchers measured changes in gum pocket depth and bleeding. The goal was to see if the probiotic co…

This study looked at whether adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning helps treat gum disease. Twenty adults with deep gum pockets and bleeding were treated on both sides of the mouth—one side got the light therapy, the other d…

This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in gum health and tooth appearance compared to those who keep smoking. Over 18 months, 460 healthy adults were followed. The goal was to mea…

This study tested a gum surgery that combines a connective tissue graft with a special protein gel (enamel matrix derivative) to help regrow bone and gum tissue in people with advanced gum disease. Seventeen adults with deep gum pockets received the treatment, and researchers mea…

This study tested whether a hyaluronic acid gel or a chlorhexidine mouthwash works better as a follow-up home treatment after deep cleaning for gum disease. Forty adults with periodontitis used one of the two products for 15 days after their dental cleaning. Researchers measured …

This study looked at whether measuring a substance called pentraxin in the fluid around teeth can help detect early gum disease in people who have fixed dentures. Researchers studied 90 patients to see if pentraxin levels could reveal inflammation that isn't visible during a regu…

This study looked at whether three specific proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers measured these proteins in 60 adults who were non-smokers and otherwise healt…

This study tested a new high-frequency ultrasound probe to see if it can measure gum pocket depth as accurately as the standard manual probing method for diagnosing periodontal disease. Thirty-nine adults participated, and researchers compared measurements from both methods. The …

This study tested a special ultrasonic cleaning device that uses hydroxyapatite (a natural tooth mineral) to reduce pain and sensitivity during gum disease maintenance. Forty adults with moderate to severe periodontitis had half their mouth cleaned with the new device and the oth…

This study tested whether adding a substance made from the patient's own blood (L-PRF) to standard gum surgery improves healing and reduces pain. Twenty-one adults with gum disease had both types of surgery on different sides of their mouth. Researchers measured pocket depth and …

This study tested whether lozenges made from propolis (a bee product) could reduce gum inflammation and plaque in 100 young adults aged 19–24 with moderate gingivitis. Participants used the lozenges for 7 days, and researchers measured gum health and saliva markers of inflammatio…

This completed study from Cairo University looked at whether people with multiple sclerosis (MS) are more likely to have gum disease. Researchers examined 293 Egyptian adults with MS, checking for signs of periodontal disease using standard dental measurements. The goal was to se…

This completed study examined the types of bacteria in the mouths of 30 people, some with gastritis (stomach inflammation) and some without. Researchers used advanced DNA sequencing to compare the oral bacteria between the groups. The goal was to see if stomach health is linked t…

This study looked at how diet affects gum inflammation in healthy people. Researchers compared vegans and omnivores by temporarily stopping their oral hygiene to see how their gums reacted. The goal was to understand if a vegan diet might reduce gum inflammation compared to an om…

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these markers. …

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study looked at 56 extracted teeth to see which polishing method — bristle brush, rubber cup, or air polishing — makes the tooth surface smoothest after scaling. Smoother teeth may help prevent plaque buildup and improve oral health. Researchers used a powerful microscope to…

This study explored the connection between gum disease severity and levels of certain antibodies (ACPAs) in people with rheumatoid arthritis. Researchers measured these antibodies in fluid from the gums before and after non-surgical gum treatment. The goal was to better understan…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This study looked at 61 adults with peripheral artery disease to see if their gum health was linked to levels of a chemical called TMAO in their blood and saliva. Researchers compared people with healthy gums, gum disease, or no teeth. The goal was to understand if oral health mi…

This study looked at 227 adults with HIV who were on antiretroviral therapy to see if poor oral health (like cavities and gum disease) is linked to metabolic problems and ongoing inflammation. Researchers measured dental health, bone density, and quality of life. The goal was to …

This study looked at 400 dental and medical students to see how their dental health relates to their quality of life. Researchers measured plaque, gum health, and cavities, and asked students about how their mouth affects their daily life. The goal was to understand differences b…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study looked at whether adding einkorn, an ancient cereal, to the diet could change the types of bacteria in the mouth. Researchers focused on bacteria linked to gum disease and cancer risk. Thirty-one healthy adults ate einkorn and had their oral bacteria measured over time…

This study looked at two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 adults with healthy gums, gingivitis, or periodontitis. Researchers measured these proteins before and after non-surgical gum treatment to see if they could help track gum inflammation and bone loss. The g…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people with obesity and gum disease (stage II or III). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link betw…

This study looked at whether people with psoriasis have worse gum health and how that affects their quality of life. Researchers examined the mouths of 226 adults (some with psoriasis, some without) and asked them to fill out questionnaires. The goal was to better understand the …

This completed study looked at 108 Turkish adults to see if understanding dental health information is linked to gum health. Participants took a reading test about dentistry and had a dental exam. The goal was to find out if people with lower health literacy have worse gum diseas…

This study looked at how smoking impacts gum health in 484 adults. Half were current smokers, half were non-smokers. Researchers measured plaque, gum bleeding, pocket depth, and gum disease severity. The goal was to understand the link between smoking habits and periodontal disea…