PERIODONTAL DISEASES

This study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will compare …

This study looks at how well 3D printed bone grafts work for supporting dental implants in people with gum disease or bone loss. Researchers will check if the implants stay stable and how much the graft shrinks over 1 to 6 years. About 100 healthy adults who already received this…

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study compares three oral care routines in 90 adults aged 60+ who have gum disease and mild cognitive impairment. One group uses a special light device plus a manual toothbrush, another uses a powered toothbrush, and the control group uses a soft manual toothbrush. The goal …

This study aims to validate an Italian version of a widely used questionnaire for screening periodontitis (gum disease). Researchers will also develop an enhanced version with additional questions and test how accurately it identifies people with the condition. About 495 adults a…

This study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and a questionnaire can accurately detect gum disease compared to a standard dental exam. Researchers will use artificial intelligence to analyze the images and combine the d…

This study is developing a new, non-invasive test for gum disease using a saliva sample and artificial intelligence. Researchers will collect saliva from 200 adults (some with gum disease, some healthy) and use a special sensor to detect disease-related signals. The goal is to cr…

This study will measure levels of oxidized LDL (a type of 'bad' cholesterol linked to heart disease) in the gum fluid of 40 adults aged 30-60. Half have severe gum disease (stage III/IV periodontitis) and half have healthy gums. The goal is to see if gum disease is connected to h…

This study follows 100 adults with healthy gums or various stages of gum disease for two years. Researchers will collect saliva and plaque samples to see if certain markers can predict who will get worse. No treatments are tested—the goal is to learn which biological signs might …

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque from 25 adults with advanced gum disease who have not yet started treatment. The goa…

This study looks at three different methods dentists use to remove a tiny amount of enamel between teeth to make room for clear aligners (like Invisalign). Seventy-five adults will be randomly assigned to one of the three techniques. The main goal is to see which method is most a…

This study looks at whether certain substances in spit and fluid around dental implants can help detect a gum disease called peri-implantitis early. Researchers will compare 80 people with healthy gums, regular gum disease, or implant-related gum disease. The goal is to find bett…

This study looks at whether teeth that bear more chewing force are more likely to have severe gum disease. Researchers will measure bite patterns in 50 adults with natural teeth or fixed dental work. The goal is to understand the link between chewing loads and gum health, which c…

This study will check levels of the Klotho gene and protein, along with certain bacteria and viruses in the mouth, in 108 adults with or without gum disease and acute coronary syndrome (a serious heart condition). The goal is to see if these factors are connected, which could hel…

This study looks at how certain proteins and antioxidants in the fluid around your gums change as your gums heal after a standard deep-cleaning treatment. Researchers will measure these substances in 21 adults with gum disease before treatment and again at 1 and 3 months after. T…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…