PERIODONTAL DISEASES

This study tests two materials for filling bone defects caused by advanced gum disease: a collagen matrix and a bovine bone mineral. Eighty adults with deep gum pockets will receive one of the materials during surgery. Researchers will measure changes in gum attachment and bone h…

This study is testing whether a special laser device (FX-405) can improve the treatment of gum disease when used along with standard deep cleaning (scaling and root planing). About 70 adults with moderate to severe gum disease will receive eight 10-minute laser sessions over five…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

This study tests whether using a toothpaste with sodium bicarbonate (baking soda) and fluoride can help maintain gum health in adults who have already had non-surgical gum treatment. One hundred participants will use either the special toothpaste or a placebo for six months, whil…

This study compares a new surgical approach for advanced gum disease to the standard method. The new technique makes a single incision in the middle of the gum between teeth and preserves the granulation tissue (healing tissue) that normally is removed. Researchers will follow 50…

This study tests whether a gel containing lovastatin, a cholesterol drug, can improve standard gum disease treatment. Researchers will compare the medicated gel to a placebo gel in 44 adults with periodontitis, including both smokers and non-smokers. The goal is to see if the gel…

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This study looks at whether vitamin D levels and supplements can reduce inflammation in people with gum disease (periodontitis or gingivitis). Researchers will measure markers of inflammation in blood and gum fluid before and after treatment. The study involves 120 adults with di…

This study tests whether adding a substance made from your own blood (injectable platelet-rich fibrin) to a standard bone graft helps repair bone damage caused by gum disease. Sixteen adults with advanced periodontitis will receive either the combination treatment or the graft al…

This study compares three different surgical methods to treat gum disease (periodontitis). The goal is to see which technique best reduces deep gum pockets and helps gums reattach to teeth. About 60 adults with gum disease will be randomly assigned to one of the three procedures.…

This study tests whether adding a special gel (rhPDGF, L-PRF, or EMD) to standard deep-cleaning helps repair bone damage from gum disease better than cleaning alone. 88 adults with advanced gum disease and bone pockets will be randomly assigned to one of four groups. Researchers …

This study is testing whether an online questionnaire can accurately assess a person's risk for gum disease (periodontitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then get a standard dental exam on the same day. Researchers will compare the two resu…

This study looks at two different stitch materials used after gum surgery to see which one helps the gums heal better in the first 10 days. About 84 adults having gum surgery will get one of the two stitches. Doctors will check healing signs like skin regrowth, bleeding, and swel…

This study tests whether using a microscope during gum surgery leads to better healing than standard dental loupes (magnifying glasses). About 25 adults with gum disease will take part. Researchers will check how well the gums heal and how long the stitching takes.

This observational study in 46 people with severe gum disease (periodontitis) aims to understand how different types of gum tissue heal after surgery. Researchers will compare tissue samples from smokers and non-smokers to see if smoking affects healing. The goal is to learn more…

This observational study looks at whether a specific immune pathway (JAK1/2) is overactive in people with gum disease (periodontitis) compared to those with healthy gums. Researchers will collect gum tissue from 30 adults to measure pathway activation. The goal is to understand t…

This study is looking for 180 adults aged 18-65 to see if certain markers in blood and saliva can predict how well someone heals from gum disease treatment. Participants will have a dental exam and provide blood and saliva samples. Those with gum disease will receive standard non…

This study looks at how the severity of pemphigus vulgaris, a chronic autoimmune skin disease, relates to gum health. Researchers will measure mouth sores and blood markers in 20 adults with the condition and compare them to gum measurements like pocket depth. The goal is to unde…

This study looks at whether training medical staff and using electronic health records can encourage older adults (55+) on Medicaid to visit the dentist more often. About 929 participants from 12 primary care clinics will be split into two groups: one where doctors get extra trai…

This study looks at how the edge of a clear aligner at the gumline affects bacteria in the gum groove. 39 people in the final phase of orthodontic treatment will wear aligners with two different edge designs—one covering 2 mm of gum, the other following the gumline exactly. Resea…

This study looks at how people's oral hygiene habits and gum health (like gingivitis or periodontitis) affect their quality of life. About 160 adults will have their gums examined and fill out a questionnaire about how their mouth feels day-to-day. The goal is to better understan…

This study looks at how antibiotics like amoxicillin and metronidazole work in the body when used with deep cleaning for severe gum disease. Researchers want to find the best dose and treatment length (3 vs 7 days) to kill harmful bacteria without overusing antibiotics. About 45 …

This study checks how often Candida albicans, a common fungus, is found in Syrian adults with gum disease (periodontitis). Researchers will collect samples from 100 patients to see if the fungus is linked to more severe gum problems. The goal is to better understand what role Can…