NON-SMALL CELL LUNG CANCER

This study tests a combination of limertinib plus chemotherapy (carboplatin and etoposide) in 30 adults with a specific type of lung cancer (EGFR-mutant NSCLC) that has transformed into small cell lung cancer after initial targeted therapy stopped working. The goal is to see if t…

This study tests whether a fecal microbiota transplant (FMT) combined with the drug tislelizumab can help people with advanced non-small cell lung cancer whose disease got worse after prior immunotherapy. The goal is to see if changing the gut bacteria can restore the immune syst…

This study tests a new drug (ANS014004) combined with a standard targeted therapy (EGFR-TKI) in people with advanced EGFR-mutated non-small cell lung cancer. The goal is to find a safe dose and see if the combination can shrink tumors or stop them from growing, especially when th…

This early-phase study tests a new drug called ITC-6146RO in about 100 adults with advanced or metastatic cancers (prostate, lung, breast, or other solid tumors) that have not responded to standard therapies. The goal is to find a safe dose and check for early signs of tumor shri…

This early-phase study tests a new daily pill, KQB368, in adults with advanced solid tumors (like lung, colon, or uterine cancer) that have a KRAS G12S or G12C mutation and no standard cure. The main goals are to find a safe dose and see if the drug can shrink tumors. About 48 pa…

This study tests a new drug called SYS6090 combined with chemotherapy or other targeted drugs for people with advanced lung cancer that cannot be removed by surgery. The goal is to see if the combination is safe and shrinks tumors. About 596 adults aged 18 to 75 with non-small ce…

This study tests two different immunotherapy drug combinations (durvalumab plus either monalizumab or oleclumab) followed by personalized radiation for people with advanced non-small cell lung cancer that has high PD-L1 levels. The goal is to see which combination works better at…

This study tests whether giving the numbing drug lidocaine during lung cancer surgery can lower the chance of the cancer returning or spreading. About 1,400 adults having minimally invasive lung cancer surgery will receive either lidocaine or a placebo through an IV. Researchers …

This study is for people with a specific type of lung cancer (EGFR-mutant) that has spread to other parts of the body after they finished a targeted therapy called osimertinib. The goal is to see if adding chemotherapy to osimertinib can help control the cancer for longer. About …

This study will test a new type of PET/CT scan that uses a special tracer called 18F-T2 to find tumors that have high levels of a protein called CAIX. About 200 adults with cancers like kidney, bladder, lung, or breast cancer will get this new scan along with a standard one to se…

This study looks at whether low-dose CT scans can help find lung cancer early in people aged 40 to 80 who have never smoked. About 2,500 participants will fill out questionnaires, give blood and urine samples, and have lung function tests and a CT scan. Researchers will track how…

This study tests a new way to perform lung surgery for early-stage non-small cell lung cancer. Surgeons will use 3D virtual reality models and a special dye (ICG) that glows under near-infrared light to see exactly which part of the lung needs to be removed. The goal is to make t…

This study looks at whether adding electro-acupuncture to usual immunotherapy and chemotherapy can help people with advanced non-small cell lung cancer. About 424 participants will receive either real or fake acupuncture during their first few treatment cycles. The main goal is t…

This observational study looks at whether changes in certain immune cells in the blood can predict how well advanced lung cancer patients respond to a combination of chemotherapy and immunotherapy. Researchers will collect blood samples from 80 participants before and after two t…

This early study tests a non-invasive device that delivers low-intensity electric fields (TTFields) to people with stage I to IIIA non-small cell lung cancer before they have surgery. The main goal is to see how these fields affect certain genes linked to DNA repair. About 18 adu…

This study compares 3D models made from CT scans without contrast dye to standard 2D contrast CT scans for planning minimally invasive lung surgery. Researchers want to see if the 3D approach is just as accurate at showing blood vessels, airways, and tumor location. About 50 adul…