COGNITIVE IMPAIRMENT

This study tested whether a nasal insulin spray combined with the diabetes drug empagliflozin can safely improve memory and thinking in people with early Alzheimer's or mild cognitive impairment. 47 adults aged 55-85 with signs of Alzheimer's in their brain took part. The goal wa…

This study tested an experimental drug called EG-501 for people with lupus who experience cognitive impairment, often called "brain fog." The trial involved 131 participants who received either the drug or a placebo for 14 weeks. The goal was to see if EG-501 could safely improve…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older with a history of cardiovascular disease who were not alrea…

This study explored whether music improvisation training can improve self-regulation and brain health in older adults, including those with mild cognitive impairment. Fifty-three participants aged 60 and older with little to no music background took part. The goal was to see if i…

This study tested whether an optimized multichannel tDCS (a gentle brain stimulation technique) works better than standard tDCS or a fake treatment for easing depression. Sixty adults with moderate-to-severe major depression received one of the three approaches. The goal was to s…

This study tested a digital sleep therapy program for adults aged 50 and older who have trouble sleeping and memory concerns. Participants used a smartphone app to learn healthy sleep habits or received general sleep education. The goal was to see if the app could reduce insomnia…

This study looked at whether physical activity or virtual reality training works better for improving physical function, thinking skills, and quality of life in people with schizophrenia. 45 adults with schizophrenia took part in the completed trial. The goal is to find which app…

This study tested whether combining two types of cognitive rehabilitation (restorative and compensatory) can improve thinking skills in people who had a stroke and now have mild memory or attention problems. 36 adults aged 50-70 with mild cognitive impairment after a stroke parti…

This study tested whether a medicine called guanfacine, given through an IV, could help critically ill patients recover from delirium and confusion faster. 46 adults in the intensive care unit (ICU) took part. The goal was to see if the drug could reduce time spent delirious or i…

This study looked at whether digital or physical brain exercises could help older adults with mild to moderate Alzheimer's disease. Over 500 people in Portugal took part. The goal was to see if these activities could improve memory, thinking, mood, and quality of life.

This study tested a hearing care program for older adults with dementia and hearing loss. Speech-language pathologists provided the care instead of audiologists. The goal was to see if this approach could reduce troubling symptoms like agitation and improve quality of life. 77 pe…

This study tested whether transplanting healthy gut bacteria (fecal microbiota transplant, or FMT) could improve sleep in people with chronic insomnia. 80 adults received either FMT capsules or placebo starch capsules. Researchers measured sleep quality using sleep tests and ques…

This study tested a new program to help brain cancer survivors with thinking, memory, and daily life. 27 survivors and their carers took part. The program focused on real-life skills and included both patients and their carers.

This study looked at whether two types of talk therapy—cognitive behavioral therapy (CBT) and relaxation training—could help people with relapsing-remitting multiple sclerosis (MS) who also have anxiety, depression, or trouble thinking. 140 people took part, attending weekly grou…

This study tested whether a humanoid robot named HUMANE could help older adults (aged 50+) living at home feel less lonely and more supported. Sixty participants used the robot for 6 weeks, and researchers measured loneliness, memory, mood, and confidence. The goal was to see if …

This study tested whether mild electrical stimulation (tDCS and tRNS) applied to the front of the brain could improve thinking and memory in 36 adults with schizophrenia. Participants completed memory and problem-solving tasks after receiving each type of stimulation. The goal wa…

This study tested whether a program combining gentle muscle vibration with tailored exercises (aerobic, strength, and balance) could help older adults in care homes who have sarcopenia (muscle loss) and frailty. Forty adults over age 75 took part. The goal was to see if this appr…

This study tested whether a community health worker (CHW) program could help people with dementia and their caregivers after a hospital stay. Researchers enrolled 34 patients and their caregivers to see if the program was feasible and acceptable. The goal was to improve caregiver…

This study looked at whether listening to personally meaningful music can improve thinking skills and daily abilities in people with late-stage Alzheimer's disease. Researchers worked with 54 older adults who had advanced Alzheimer's. They measured changes in memory, attention, a…

This study tested a 7-week program to help older adults with both chronic pain and mild memory problems manage their pain better. Participants received weekly phone coaching and watched educational videos. The goal was to see if the program was practical and could reduce how much…

This study tested a 4-week virtual reality (VR) cognitive training program in 62 people with stable mood disorders (depression or bipolar) or psychosis spectrum disorders (like schizophrenia). The program used simulated daily-life challenges to improve thinking and daily function…

This study tested whether virtual music therapy with active participation works as well as in-person music therapy for reducing stress in older adults with memory problems. Thirty-two participants from assisted living facilities took part. Researchers measured stress levels, hear…

This study tested a 12-week intensive aerobic and resistance exercise program in 58 adults aged 40-85 with type 2 diabetes and thinking problems. The goal was to see if exercise could improve memory, metabolism, inflammation, and physical function. Participants were grouped by ri…

This study tested a 6-week outpatient rehab program for 125 adults with Long COVID. The program included exercises for breathing, strength, balance, and thinking skills. The goal was to see if it helps people walk farther and feel better in daily life.

This study tested a program where older Black caregivers, their loved ones with dementia, and a support person walk together while looking at old neighborhood photos on a tablet. The goal was to see if this combination of physical activity and social reminiscing could improve car…

This study tested whether a drug called galantamine, combined with a specific brain-training program, could improve thinking and memory in people who had a first stroke 3 months earlier. 47 adults aged 35-70 took part. The goal was to see if the combo helped brain activity and da…

This study looked at whether walking while doing simple thinking tasks (like counting or naming things) can help older adults with brain fog. 90 people aged 65+ with brain fog took part. They were split into two groups: one walked while doing mental tasks, the other just walked. …

This study tested a special training program that combines thinking exercises with whole-body vibration (standing on a gently vibrating platform) to see if it helps older adults with mild to moderate memory and balance problems. Fifty adults aged 60 to 75 with cognitive impairmen…

This study tested an online platform called LifeBio Memory that helps people with dementia and their caregivers share and record life stories. The platform uses machine learning to turn speech into text, making it easier to create personalized life story materials. 234 residents,…

This study tested a new program that screens older adults (60+) for memory and thinking problems after they leave the intensive care unit (ICU). The goal was to see if the screening is practical and helps connect people to support. About 109 participants took part, and the progra…

This study looked at how lung damage from COPD in smokers might lead to changes in the brain and problems with thinking. Researchers studied 170 adults aged 30-85 using brain scans and thinking tests. The goal was to understand these connections early in COPD to help design futur…

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted care. 26 residents, family members, and staff took part to see if the robot helped with engagement and mood. The goal was to understa…

This study looked at whether music therapy can protect thinking skills and wellbeing in healthy older adults and those with mild-to-moderate memory problems. Over 200 people aged 65+ took part in 5 months of music sessions, either one-on-one or in groups, and some used robotic he…

This study tested a simpler version of a cognitive test called Link's Cube, which measures planning and problem-solving skills. Researchers worked with 30 healthy adults to see if using fewer, larger blocks makes the test easier to use at a patient's bedside. The goal was to find…

This study tested a computer system that helps doctors identify older patients at risk for memory problems or dementia. Over 3,200 adults aged 65 and older took part. The goal was to see if the tool could lead to earlier diagnosis and better care planning, without requiring extra…

This study looked at whether inflammation in belly fat can cause confusion or memory problems after surgery. Researchers followed 115 patients having hip or heart surgery. They measured thinking skills and checked fat tissue for signs of inflammation. The goal was to understand i…

This study tested a special device that sprays insulin into the nose to see how much gets into the brain. Insulin is a hormone that helps control blood sugar, but it may also affect memory. The study included 20 adults with mild memory problems or normal cognition. Researchers me…

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other markers related to brain health. The goal was to understand how exerc…

This study examined whether people with type 2 diabetes who have nerve damage (neuropathy) also have more trouble with memory and thinking. Researchers tested 101 volunteers, some with diabetes and some without, using memory quizzes, nerve checks, and brain scans. The goal was to…

This study looked at 129 older adults (65+) having planned orthopedic surgery to see if certain substances in the blood and spinal fluid are linked to frailty and thinking problems. Researchers wanted to know if these biomarkers could help identify vulnerable patients early. The …

This study tested whether giving insulin through the nose can help people with mild memory problems. Researchers measured how much insulin reached the brain fluid and checked its effect on memory. The study included 13 adults with normal cognition or mild cognitive impairment.

This study tested a program called SHARE that helps older adults with memory problems and their family caregivers talk to their doctors about healthcare wishes. About 248 patient-caregiver pairs took part across 9 primary care clinics. The goal was to see if the program improves …

This study tested a program called Home Alone for older adults with memory problems who live by themselves. The goal was to see if the program was helpful and acceptable. Participants worked with a coach in weekly sessions to stay active, engaged, and safe at home. The study invo…

This study tested whether a 40-hour, 8-week cognitive telerehabilitation program done at home can reduce the risk of memory and thinking problems 6 months after a stroke. 86 adults who recently had a stroke took part. The treatment group did the online brain training, while the c…

This study tested a new way to improve thinking skills by combining brain-training games with low-oxygen air (like being at high altitude). 190 healthy adults and people with depression or bipolar disorder took part. The goal was to see if this approach could boost memory, focus,…

This study tested whether a new type of occupational therapy could help people with mild-to-moderate thinking problems after a stroke manage daily tasks like dressing or cooking. Only 8 people took part, and the goal was to see if the therapy was practical to deliver and study, n…

This study looks at whether blood vessel problems contribute to memory decline in older adults with high blood pressure who have memory complaints. Researchers will measure artery stiffness and brain scans in 131 participants over time. The goal is to understand the link between …

This study tested whether a nurse-led walking and sit-to-stand program is practical and liked by older adults with cognitive issues like dementia in transitional care. Six participants took part to see if the program could improve strength, mobility, and quality of life. The main…