COGNITIVE IMPAIRMENT

This study tested a special device that sprays insulin into the nose, aiming to deliver it directly to the brain. Researchers wanted to see if this method could increase insulin levels in the fluid around the brain and potentially improve memory in people with mild cognitive impa…

This study tested whether a 12-week intensive exercise program could improve brain function and overall health in middle-aged and older adults with type 2 diabetes. Researchers enrolled 58 participants, assigning some to the exercise program and others to continue their usual car…

This study tested whether a new type of brain stimulation works better for depression than the standard method. Researchers compared three approaches in 60 adults with moderate-to-severe depression: a new multi-channel stimulation, the conventional stimulation, and a sham (fake) …

This study tested whether a drug called EG-501 could improve thinking and memory problems, often called 'brain fog,' in people with lupus. 131 adults with lupus and confirmed cognitive impairment were randomly assigned to receive either EG-501 or a placebo (inactive substance) fo…

This study tested whether a nasal insulin spray and a diabetes pill (empagliflozin), alone or together, could help people with early memory loss or Alzheimer's disease. It involved 47 adults aged 55-85 who showed early signs of Alzheimer's. The main goal was to check if the treat…

This study tested whether an intravenous form of the drug guanfacine could help treat delirium (acute brain confusion) in patients who are critically ill in the ICU. The goal was to see if the treatment could reduce the number of days patients experienced delirium or coma, help t…

This study tested whether a special three-week program could improve thinking skills. Participants, including healthy adults and people with stable depression or bipolar disorder, spent time in a room with low oxygen levels (like being at high altitude) while doing brain-training…

This study tested whether combining two different brain training approaches could help stroke survivors with mild thinking problems. Researchers worked with 36 participants who had experienced a stroke and had mild cognitive impairment. They compared different rehabilitation tech…

This study tested a computer program designed to help primary care doctors identify older adults at risk for dementia or memory loss. The tool, integrated into the clinic's electronic health record, flagged at-risk patients and gave doctors resources for next steps like assessmen…

This study tested a new program designed to check for memory and thinking problems in older adults after they leave the intensive care unit (ICU). It involved 109 people aged 60 and older who had a long ICU stay. The program screened patients at 6 weeks and 6 months after dischar…

This study tested whether a 24-week program of home-based physical activity and computer brain training could help prevent or delay memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older to compare different combinations of the exercise an…

This study tested whether a social robot could help people with dementia or memory problems feel more connected and engaged. Researchers gave a tablet and a robot to residents in an assisted living community for three weeks. The goal was to see if the robot's activities, like tri…

This study tested whether listening to personalized, favorite music could help improve daily living skills and cognitive function in people with advanced Alzheimer's disease. It involved 54 participants aged 65 and over who were diagnosed with late-stage Alzheimer's. Researchers …

This small pilot study tested whether a phone-based coaching program could help older adults who have both chronic pain and memory problems. Participants received weekly phone calls from a health coach and watched educational videos about managing pain at home. Researchers wanted…

This small study tested whether a new type of occupational therapy is practical to use for people who have trouble with daily activities after a stroke due to thinking problems. The therapy was designed by experts to help with tasks like getting dressed, cooking, and managing a h…

This study tested a new brain training program designed to help people who have survived brain cancer but are struggling with memory, thinking, or behavior changes. The program involved both the patient and a family caregiver to help practice new skills at home. Researchers wante…

This study tested whether taking capsules containing healthy gut bacteria from a donor (fecal microbiota transplantation) could improve sleep for people with chronic insomnia. 80 participants were randomly given either the real treatment capsules or identical-looking placebo caps…

This study tested whether a digital sleep therapy app could reduce insomnia in adults aged 50 and older who also reported memory or thinking problems. Researchers compared the app, which guides users through sleep improvement techniques, against basic online sleep education. The …

This study tested a new home-based coaching program designed to help older adults with memory loss who live alone. The program involved weekly meetings with a coach to help participants stay active, safe, and socially connected at home. Researchers wanted to see if the program wa…

This study compared two different activity programs to see which might better help people with schizophrenia. Researchers tested whether regular physical exercise or training using virtual reality (VR) could improve physical abilities, thinking skills, and quality of life. The st…

This study tested a program called SHARP-CG, designed to support older Black caregivers of people with dementia. Small groups walked together three times a week for 16 weeks, using a tablet to view historical photos of their neighborhood as conversation starters. Researchers meas…

This study tested whether a 4-week virtual reality (VR) brain training program could improve thinking skills and daily functioning in people with stable depression, bipolar disorder, or schizophrenia. 62 participants were randomly assigned to receive either the active VR cognitiv…

This study tested a new online tool designed to make it easier for caregivers to help people with dementia share their life stories. The tool uses speech-to-text and artificial intelligence to create personal storybooks from conversations. Researchers wanted to see if using these…

This study tested a 6-week outpatient rehabilitation program designed to help people with Long COVID. The program included tailored physical therapy, breathing exercises, and brain training to address common symptoms like fatigue, shortness of breath, and thinking problems. Resea…

This study tested whether music therapy could help older adults maintain their thinking skills and improve their quality of life. It involved 210 people aged 65 and over, including those who were healthy and those with mild to moderate memory or thinking problems. Researchers com…

This study tested whether two types of group talk therapy could help people with multiple sclerosis (MS) feel better and think more clearly. Researchers compared a cognitive behavioral therapy (CBT) program and a psychophysiological regulation therapy to standard care in 140 part…

This study tested a new way to provide hearing care to people living with dementia at home. A speech-language pathologist delivered affordable hearing help instead of an audiologist. Researchers wanted to see if this improved patients' behavioral symptoms and overall quality of l…

This study tested whether two types of gentle, non-invasive electrical brain stimulation could improve thinking skills like memory and problem-solving in people with schizophrenia. Thirty-six adults with schizophrenia received different stimulation types in a random order to see …

This study tested whether a special exercise program that combines mental tasks with physical movement, plus whole-body vibration therapy, could help improve thinking skills and balance in older adults with mild to moderate memory and thinking problems. Fifty participants aged 60…

This study tested three different nasal spray devices to see how effectively they could deliver insulin to the brain fluid. Researchers also checked if the insulin affected memory. The goal was to gather information to help design better future studies, not to treat or cure memor…

This study looked for connections between physical frailty, memory problems, and specific markers in the blood and spinal fluid of older adults having planned bone or joint surgery. Researchers tested 129 patients over 65 to see if these biological markers, related to brain infla…

This study aimed to understand why some people experience confusion and memory problems after surgery, a condition known as post-operative cognitive dysfunction (POCD). Researchers followed 115 patients having hip or heart surgery to see if inflammation from body fat, especially …

This study aimed to understand how exercise might help protect the aging brain. Researchers had 60 healthy but inactive adults aged 50-80 complete a 12-week, supervised exercise program. They measured changes in thinking skills and specific hormones in the blood before and after …

This study explored whether taking music improvisation classes could help improve self-regulation and thinking skills in older adults. Researchers enrolled 53 adults aged 60 and over, some with mild memory concerns and some without, to test the new training program. The goal was …

This study aimed to understand if the health of a person's blood vessels is linked to changes in their memory and thinking skills over time. It followed 131 older adults with high blood pressure who had concerns about their memory. Researchers measured blood vessel stiffness and …

This study aimed to understand why many people with COPD (a serious lung disease often from smoking) also experience problems with memory and thinking. Researchers examined 170 smokers, some with early signs of lung damage, using brain scans and thinking tests. The goal was to id…