COGNITIVE IMPAIRMENT

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study tests whether a device that delivers light and sound stimulation for 60 minutes each day can slow the decline in memory and daily living skills in people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inac…

This study tests whether a lower blood pressure target than the current standard can reduce major heart problems and strokes in people who have already had a stroke. About 4,300 participants will be randomly assigned to either intensive or standard blood pressure control and foll…

This large study tests whether lowering blood pressure more than usual can prevent major heart problems, strokes, and memory loss in people with type 2 diabetes. About 9,500 participants with high blood pressure and diabetes are being followed to compare intensive versus standard…

This study is testing a new automated tool that helps primary care doctors quickly screen older adults for early memory and thinking problems. The tool uses simple symbol matching and voice tasks on an iPad to give a risk score. Researchers hope it will make screening easier and …

This study tests whether teaching memory support strategies and promoting healthy activities like exercise, mental challenges, and stress management can improve memory and daily thinking in older adults who are worried about their memory. About 263 people aged 65 and older with n…

This study looks at whether a group program combining visual art-making and dual-task exercise games can improve thinking, balance, and walking in older adults. About 80 participants with mild cognitive or physical issues will take part. The goal is to see if this fun, community-…

This study looks at whether a 20-week program of physical exercise, with or without added cognitive training (like brain games), can improve thinking skills in breast cancer survivors. 108 women who have finished primary cancer treatment will take part. Researchers will measure c…

This study tests a therapy program delivered remotely via a software platform to help reduce anxiety in people with mild cognitive impairment or dementia. About 70 participants will receive the therapy, and researchers will measure changes in anxiety and quality of life. The goal…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a special video game that challenges balance and thinking, while a coach supervises them remotely via telemedicine. The goal is to see if this approach ca…

This study aims to find out what factors can predict changes in thinking and memory after deep brain stimulation (DBS) for Parkinson's disease. Researchers will test 30 patients before and up to 5 years after surgery using brain scans, thinking tests, and other measures. The goal…

This study aimed to see if asking patients four simple questions about their thinking abilities during a yearly checkup would lead doctors to order more tests or referrals for memory issues. Researchers planned to compare doctor behavior before and after adding the screener. Howe…

This study looks at how healthy children's thinking skills (like reasoning) change as they grow. By testing 100 kids aged 6 to 16 twice over a year, researchers hope to create better tools to spot when a child's brain has been hurt by injury or disease. The goal is to improve dia…

This study looks at 45 adults having carotid artery surgery to see if special scans can predict who will have better thinking skills afterward. Researchers check for inflammation in the artery wall and brain, and link it to changes in memory and thinking. The goal is to learn whi…

This study looks at whether young adults (ages 21-25) who regularly use high-potency cannabis concentrates can improve their memory, attention, and other thinking skills by switching to less potent products. Researchers will track participants' cannabis use, collect blood and uri…

This study looks at 1000 people who may have a rare genetic form of obesity, like Bardet-Biedl syndrome. Researchers will use genetic testing to find the cause and better understand how these conditions affect the body. The goal is to improve early diagnosis and care for those wi…

This study looks at how much older adults move while in the intensive care unit (ICU) for a critical illness like sepsis or respiratory failure. Researchers want to see if more activity during the hospital stay leads to fewer disabilities and better physical and mental function 3…

This study looks at whether people with atrial fibrillation (an irregular heart rhythm) experience temporary changes in thinking, memory, or focus during an episode. About 600 participants will take tablet-based cognitive tests while in atrial fibrillation and again when their he…

This study is creating a large database of information from 250 older adults (65+) having surgery. Researchers collect blood samples, brain wave recordings, and memory tests before and after surgery. The goal is to find patterns that could one day help predict who might experienc…

This study tests a research PET scanner that can take pictures of most of the body at once, unlike current machines that only scan small sections. About 268 healthy adults and people with cognitive issues will be scanned to see how well the machine works. The goal is to gather in…

This study follows 120 people in group therapy for alcohol use disorder to see which patient traits—like mental health, drinking severity, personality, or thinking skills—predict success. Researchers want to help doctors choose the right therapy for each person. The goal is bette…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will follow 505 adults aged 50 and older to see how many experience mental fogginess (called postoperative cognitive dysfunction) up to 4.5 months after surgery. The goal …

This study looks at whether fixing a blocked carotid artery (a major blood vessel in the neck) can reverse thinking and memory problems in people who have no stroke symptoms. About 385 participants from a larger trial will have brain scans and thinking tests over one year. The go…

This study tests whether a program of computer brain games and supervised physical exercise, done before and after major surgery, can help older adults (age 60+) maintain their thinking skills and physical abilities. 250 participants will be randomly assigned to either the traini…

This study looks at whether doing computer-based brain exercises in the morning or late afternoon helps older adults (60+) recover thinking skills after an ICU stay. Many ICU survivors have trouble with memory and attention, plus disrupted sleep cycles. The goal is to see which t…

This study aimed to understand how changes in blood pressure when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare those with and without orthostatic hypotension (low blood pressure upon standing) using …

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that may lead to thinking problems in CKD patients. Participan…

This study looks at how a serious injury or burn that requires ICU care can affect thinking and memory years later. Researchers are following 432 adults to measure long-term cognitive problems and understand how inflammation in the body might play a role. The goal is to learn why…

This study looks at why many ICU patients develop severe, long-lasting muscle weakness after critical illness. Researchers will use muscle biopsies, ultrasound, and strength tests in 50 adults to better understand the condition. The goal is to improve diagnosis and monitoring, no…

This study looks at whether learning music improvisation can help older adults (60+) better regulate their thoughts and actions. Researchers will compare participants who take improvisation training to those who don't, measuring changes in cognitive skills and brain activity. The…