COGNITIVE IMPAIRMENT

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The program includes digital tools, personalized guidance, and ongoing support. Researchers will compare it…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help prevent or slow memory loss in people with cerebral small vessel disease, a common cause of cognitive decline. Forty adults aged 30-80 with mild cognitive impairment will receive …

This study tests whether eating foods with resistant starch (a type of fiber) can slow down memory loss in people at high genetic risk for cognitive decline. About 70 adults aged 40 and older with certain risk factors will be randomly assigned to eat either high-resistant starch …

This study aims to see if a non-invasive brain stimulation technique (rTMS) and computer-based thinking exercises can improve mental flexibility in adults with major depression. Researchers will use brain scans to target specific areas thought to be involved in this thinking prob…

This study will see if an artificial intelligence (AI) tool can analyze speech recordings to help identify people with memory problems who need specialist dementia care. Researchers will record 440 Danish-speaking adults over 50 as they perform cognitive tests and speaking tasks.…

This study tests a 6-week virtual rehabilitation program to help prevent falls in older veterans who have memory or thinking problems. Falls are a major cause of injury and hospitalization in this group. The program will be delivered remotely, and researchers will measure how wel…

This study tests whether giving home health aides extra training in dementia care can help reduce troubling behaviors in older adults with memory loss or dementia and improve quality of life for both patients and their care partners. About 120 patient-care partner pairs will take…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve cognitive function in adults aged 50 to 90 with mild to moderate memory or thinking problems. Participants will receive six sessions of targeted magnetic pulses over three weeks. Researche…

This study tests whether a handheld robot that vibrates and talks can help older adults with mild memory problems sleep better. 100 participants will compare robot-guided meditation to standard audio-only meditation. The goal is to see if the robot's touch and rhythm make it easi…

This study tests a 10-session program called ViCCY to help caregivers of heart failure patients who also have memory issues. About 256 caregivers and 60 patients will take part. The goal is to see if the program reduces stress and improves the caregiver's mental health and abilit…

This study tests whether N-Acetyl-Cysteine (NAC), a supplement, can reduce memory and thinking problems caused by chemotherapy in ovarian cancer patients. About 102 women with advanced ovarian cancer will take NAC alongside their standard platinum-based chemo. The goal is to find…

This study tests whether the antibiotic minocycline can safely stop or reverse thinking and memory problems in adults with sickle cell disease. The drug may reduce brain inflammation that causes cognitive decline. Thirty participants will take either a low dose, high dose, or pla…

This study compares two brain training programs for adults with long-lasting brain fog after a viral illness, including ME/CFS or post-COVID. Thirty participants will do about 30 hours of online training over 2-4 weeks, plus three in-person visits for blood tests and brain scans.…

This study tests a new medicine, Xanomeline/Trospium (XT), to see if it can improve thinking and memory in adults with schizophrenia over 24 and 52 weeks. About 171 participants will take XT and have their cognitive skills, symptoms, and quality of life measured. The goal is to f…

This study tests whether aerobic exercise, alone or with a gentle brain stimulation technique called tDCS, can improve memory and attention in people with treatment-resistant schizophrenia. About 160 adults will take part in a 6-week program. The goal is to find a safe, drug-free…

This study tests whether standing on a gently vibrating platform for 25 minutes, three times a week, can improve thinking, balance, and daily life in older adults with mild cognitive impairment. About 180 people aged 60 and older will be randomly assigned to vibration, a fake pla…

This study tests a noninvasive brain stimulation technique called transcranial magnetic stimulation (TMS) to see if it can improve memory and thinking in people with bipolar disorder. Researchers will enroll 88 adults with stable bipolar disorder and give them either real or fake…

This study tests whether a special type of bright light therapy can improve thinking and memory problems in people with major depression. About 120 adults with depression and cognitive issues will either receive the special light or a dim red placebo light for four weeks. Researc…

This study looks at whether a kidney transplant-specific check-up for older adults (aged 60+) with advanced kidney disease can help doctors make better decisions about who is suitable for a transplant. About 50 participants will either receive this extra assessment plus usual car…

This study looks at 400 older adults (65+) having planned hip replacement surgery in the Czech Republic. Researchers want to see if a short memory test given before surgery can predict who might become confused or delirious afterward. The goal is to make routine memory checks sta…

This study explores whether advanced eye and brain imaging can help diagnose and treat nerve and blood vessel damage caused by diabetes. Researchers will test a Chinese herbal medicine called Tangshen'an Granule in 160 adults aged 18-70 with diabetes. The goal is to see if the im…

This study looks at how to best measure confusion and memory problems that some older people experience after major surgery. Researchers will ask 40 patients aged 70 and older to do memory tests and give blood samples before and after their operation. The goal is to see if these …

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention in people who use cannabis often versus rarely. Researchers will give 40 healthy adults either a placebo, a low dose, or a high dose of THC and test their eye con…