COGNITIVE IMPAIRMENT

This study tests whether adding a natural milk component (MFGM) to a standard therapeutic food can improve brain development and reduce death or hospitalization in 1,600 severely malnourished children aged 6–59 months in Sierra Leone. Children receive either the enhanced or stand…

This study tests a telehealth program called C-READY that aims to improve thinking skills and self-management in 120 teens with sickle cell disease. Participants will complete online exercises and coaching to help them prepare for transitioning from pediatric to adult healthcare.…

This study tests whether adding choline to a special peanut-based food helps brain development in children with severe malnutrition. About 1,500 children in Malawi, ages 6 months to 5 years, will receive either standard food or food with extra choline. Researchers will measure th…

This study tests whether metformin, a common diabetes medicine, can help children and teens recover memory and thinking skills after finishing brain tumor treatment. About 140 participants aged 7 to 22 will take metformin or a placebo for 16 weeks. Researchers will measure change…

This study is testing a new automated tool that helps primary care doctors quickly screen older adults for early signs of memory loss or cognitive decline. About 100 Spanish-speaking adults aged 60 and older will use an iPad to complete symbol matching and voice tasks. The goal i…

This study is testing whether a blood test can help screen for Alzheimer's disease in older adults living in the community. Researchers will enroll 3,000 people aged 60-80 and measure specific blood markers. Those with abnormal results will receive further cognitive testing to se…

This study compares a new, smaller and mobile PET scanner (Radialis PET Imager) to standard PET/CT or PET/MR scanners for imaging amyloid plaques in the brain. Amyloid plaques are a hallmark of Alzheimer's disease. The goal is to see if the new device can produce equally useful i…

This study tests whether a virtual reality (VR) platform can accurately measure thinking and movement skills, like balance, attention, and hand coordination. About 200 healthy volunteers and people with neurological conditions will take both standard tests and VR versions to see …

This study tests a simple 5-minute cognitive assessment called 5-Cog to help primary care doctors detect dementia and mild cognitive impairment earlier. It involves 6,600 older adults in 22 clinics in the Bronx and Indiana, focusing on communities that often face health dispariti…

This study tests whether a program of nutrition education, physical activity, and at-home cognitive training can help prevent memory decline in adults aged 55 to 85 who are at higher risk for dementia. Over 120 participants will follow a Mediterranean diet-focused plan and attend…

This study tests whether MitoQ, an antioxidant supplement, can improve thinking and memory in people with early schizophrenia who have signs of mitochondrial problems. Researchers will give MitoQ or a placebo to 50 eligible participants for 12 weeks, alongside their usual medicat…

This study tests a video-based program for older adults (65+) with cancer and mild memory problems, along with their spouse or caregiver. Participants attend six 60-minute video sessions and complete surveys to see if the program reduces distress and improves well-being. The goal…

This study tests if a special website can help people who survived a cardiac arrest outside the hospital. The goal is to improve their quality of life, mood, thinking, and social connections. About 106 survivors will use the web app and report how they feel.

This study tests a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) to see if it can safely improve thinking and memory in people with cerebral small vessel disease. About 58 adults aged 45-80 with cognitive impairment will receive iTBS …

This study tests whether children with sickle cell disease (ages 8 to 17) can safely take a daily stimulant medication (methylphenidate) for 4 weeks to improve attention, thinking, and school performance. Researchers will check for side effects and measure changes in cognitive sk…

This study tests whether butylphthalide, a drug already used for stroke, can improve memory and thinking in older adults (ages 60-85) who have focal epilepsy and mild to moderate cognitive problems. About 220 participants will take either the drug or a placebo for 48 weeks while …

This study tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can help children aged 10-15 recover from a mild concussion. The researchers will measure improvements in balance, coordination, and thinking skills. The goal is to…

This study compares doing rehab exercises at home via video (tele-rehabilitation) versus going to a clinic for stroke survivors with mild to moderate thinking problems. About 32 adults aged 50-80 who had a stroke will participate. The goal is to see if remote therapy is as effect…

This study tests whether combining a ketogenic diet supplement with online brain training can improve thinking skills in blood cancer survivors. About 80 adults with mild to moderate memory or focus problems will be randomly assigned to either start the program right away or wait…

This study tests whether playing on a maze balance board can improve movement and balance in children aged 6-10 with mild to moderate cognitive impairment. Twenty-two children will be split into two groups: one doing maze board exercises and the other doing standard physical ther…

This study tests a special therapy called PATH-Pain for 100 older adults (60+) who have mild memory problems, chronic pain, and depression. The therapy teaches problem-solving skills to help manage pain and improve mood and thinking. Participants are compared to those receiving u…

This study tests a special hearing program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and confusion, and lessen the stress on caregivers. About 300 p…

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, have MRI brain scans, and complete memory and physical te…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking in breast cancer patients undergoing chemotherapy. About 90 women with early-stage breast cancer will be split into three groups: memantine plus exercise, mema…

This study tests whether a 12-week sitting Tai Chi program can improve thinking, movement, mood, and daily function in chronic stroke survivors who have memory or thinking problems. About 176 participants (88 stroke survivors and 88 caregivers) will be randomly assigned to either…

This study tests a twice-weekly, moderate-intensity exercise and coaching program for 50 adults with mild-to-moderate cognitive impairment. Participants will either join in-person group sessions or exercise from home. Researchers want to see if the program is practical and enjoya…

This study looks at whether a computer brain-training program called Lumosity can help improve memory and thinking in people who have had a stem cell transplant for blood cancer. About 60 adults who are 3 to 6 months post-transplant will either start training right away or wait 1…

This study tests whether a three-week program combining a daily supplement (sodium butyrate) with virtual reality-based cognitive training can improve memory, attention, and other thinking skills in 160 middle-aged and older adults who have had depression or bipolar disorder but …

This study looks at whether adding acupuncture to standard Alzheimer's medication (Donepezil) can improve memory, thinking, and daily living skills. Researchers will compare two groups of 90 people each over 12 weeks. The goal is to see if the combination works better than medica…

This study tests whether virtual cycling—pedaling a stationary bike while watching an interactive film—can improve quality of life for older adults with cognitive impairment living in nursing homes. Researchers will compare quality-of-life scores between a group that cycles and a…

This study is testing whether a wearable robotic exoskeleton can improve walking, memory, and thinking in people with multiple sclerosis who have trouble walking. Ten participants will use the device during therapy and be compared to those receiving traditional therapy. The goal …

This study tests whether a gentle brain stimulation technique called tDCS, combined with computer-based thinking exercises, can improve memory and thinking in people who have had a mild stroke. About 60 adults who had a stroke within the past week will be randomly assigned to rec…

This study tests whether playing brain-training games in virtual reality can improve memory, attention, and thinking skills in adults who recently left the intensive care unit (ICU). About 51 participants will either use a VR headset, a tablet, or receive standard care. The goal …

This study compares two 30-hour cognitive rehab programs for 30 adults with long COVID who have mild to moderate brain fog. Both programs use computer games, in-person training, and a mild nerve stimulation device. One program focuses on thinking skills and work tasks, while the …

This study tests a new drug, ALTO-101, given through a skin patch, to see if it helps with thinking and memory problems in people with schizophrenia. About 82 adults with stable schizophrenia and cognitive issues will receive either the drug or a placebo, then switch. The main go…

This study tests whether a diet rich in fermented foods (like yogurt, kimchi, and sauerkraut) is tolerable and can improve quality of life for people who survived a critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation, which …

This study tests a 6-week exercise program for older adults (ages 65-90) who recently finished home health care and have trouble moving or thinking. Participants will do task-oriented resistance exercises at home with a care partner. The goal is to see if this program is practica…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with standard cognitive therapy, can improve memory and thinking in people who recently had a stroke. Researchers will enroll 70 adults aged 18-90 who had a stroke within the past mont…

This study tests whether immersive virtual reality exercises can improve thinking skills in people with cancer who have memory and attention problems after chemotherapy. About 60 participants will either do virtual reality activities or continue usual care. The goal is to see if …

This study tests whether mindfulness training can help people with both heart failure and mild memory problems improve their self-care and thinking skills. About 176 adults will take part. The goal is to see if learning to focus on the present moment helps them manage their condi…

This study looks at why people with severely narrowed arteries in the brain may have memory and thinking problems. Researchers will follow 100 adults aged 18 to 80 who have had a mini-stroke or minor stroke due to this condition. They will test memory and track any new strokes to…

This study aims to see if a quick cognitive test, given during regular check-ups, can help doctors detect early memory problems or dementia in underserved communities. Over 45,000 adults without prior diagnosis will take part across 24 clinics. The goal is to improve early detect…

This study looks at how common memory problems are in people aged 65 and older with type 2 diabetes. It also tests whether a program that combines healthy habits, exercise, and mental activities can help prevent or slow down memory decline. The study involves 420 participants fro…

This study looks at 300 adults with new memory or thinking problems to see if certain immune system markers (antibodies) are involved. Researchers want to learn how often these antibodies appear and if they can help diagnose a type of dementia caused by the immune system. Partici…

This study looks at how endocrine therapy, a common breast cancer treatment, affects brain function and thinking skills in 120 women aged 35-65. Researchers will compare brain scans and cognitive tests between survivors on therapy and healthy women, focusing on the role of menopa…

This study looks at how removing a type of brain tumor called a meningioma affects a person's thinking and memory over a year. Researchers will test 50 adults before and after surgery to see if their cognitive skills change. The goal is to better understand the long-term effects …

This study looks at how the brain works during thinking tasks like remembering or paying attention. Researchers will record brain activity from 30 adults with epilepsy who are already having brain surgery for seizures. The goal is to better understand conditions like dementia, AD…

This study looks at whether a gentle electrical current applied to the scalp (tDCS) can improve working memory in older adults with mild cognitive impairment (MCI). Researchers will compare results from 110 participants aged 60-95, including both people with MCI and healthy older…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study looks at how well different tests can predict whether a patient with low blood pressure and impaired consciousness will benefit from receiving extra fluids. The researchers will compare several methods, including leg raising and fluid challenges, in 222 adults in inten…

This study looks at what 'visual frailty' means for people aged 60 and older who have age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to create a new assessment tool. The goal is …

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and how to talk about it with doctors. About…

This study looks at whether high-intensity exercise can help older adults with HIV improve their thinking and memory, and make exercise a lasting habit. Researchers will enroll 110 sedentary people with HIV who report fatigue. Participants will join a supervised exercise program …

This study looks at two types of radiation for a slow-growing brain tumor near important brain areas. It compares proton therapy with standard photon radiation to see which causes fewer long-term problems with memory, thinking, and vision. About 160 adults aged 18 to 70 with this…

This study looks at whether a web-based platform can be used to deliver cognitive and speech therapy to adults with brain injuries from stroke or critical illness. About 80 participants will use the platform instead of traditional paper-based therapy. The goal is to see if it's p…

This study is testing a new job training program that uses virtual reality to help people with schizophrenia improve their job interview skills. About 40 adults aged 20 to 55 who are stable and motivated to work will take part. The goal is to see if the program can boost their ab…

This study looks at 65 adults with obstructive sleep apnea to see how three weeks of breathing therapy (ventilotherapy) changes their thinking skills, blood markers linked to brain health, and overall well-being. Participants take thinking tests, give blood samples, and answer qu…

This study aims to create and improve tests that measure thinking, memory, and social skills in people with brain conditions like dementia or psychiatric disorders. Researchers will test these new tools on 300 healthy volunteers and patients to see how well they work. The goal is…

This study aims to understand why some people experience changes in thinking and memory as they get older. Researchers will use brain scans (MRI and PET) and memory tests to detect early signs of decline in 300 healthy adults aged 60 and older. The goal is to find better ways to …

This study is creating a registry of 50 adults aged 50 and older who have cerebral small vessel disease (CSVD), a common age-related condition that can cause thinking problems. Researchers will track changes in memory tests and brain scans over 6 months. The goal is to build a sy…

This study looks at how different types of dietary fats affect thinking and memory in adults who have mild memory complaints. Over 88 participants will eat a special snack each day for one week. Researchers will measure brain function and gut health to see if certain fats can hel…

This study tests whether a special program can reduce confusion (delirium) after surgery in older adults. Researchers will screen patients aged 60 and older before their operation to find those at highest risk. Those identified will receive extra care recommendations and educatio…