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Zapping the brain to sharpen the mind in schizophrenia

NCT ID NCT06155786

Symptom relief Sponsor: The National Brain Mapping Laboratory (NBML) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether two types of mild electrical brain stimulation (tDCS and tRNS) could improve memory and thinking in 36 people with schizophrenia. Participants received both types of stimulation on different days to compare effects. The goal was to see if these safe, non-invasive techniques could help with cognitive problems that often come with schizophrenia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS) and transcranial random noise stimulation (tRNS) devices
What this could lead to
If it works, this could point toward a non-drug way to help people with schizophrenia think more clearly and remember better.
What could go wrong
This is a small, early-stage study with only 36 participants. The effects may be small or not last long, and results may not apply to everyone with schizophrenia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Jan 2023

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of schizophrenia based on Diagnostic and Statistical Manual (DSM)5 * Being 18-50 years old (male and female) * If female, negative urine pregnancy test * feasibility for tDCS/tRNS interventions according to safety guidelines * stable medication regime, especially for classical neuroleptics and all central nervous system activating medications, if taken, 4-6 weeks before the experiment * fluency in the native language * right-handed * Required written informed consent signed by patients' guardian Exclusion Criteria: * pregnancy * alcohol or substance dependence * comorbid bipolar disorder and mood disorder * history of seizure * history of neurological disorder * history of head injury * Presence of ferromagnetic objects in the body that are contraindicated for brain stimulation of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments)

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive impairment Schizophrenia

Contacts and locations

Locations

  • Payame Noor University, Tehran Branch

    Tehran, Iran

  • Zanjan University

    Zanjān, Iran

More trials for these conditions

Other studies related to the condition(s) this trial covers.