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New hope for lupus brain fog: experimental drug shows promise in trial

NCT ID NCT07281105

First seen Jan 06, 2026 · Last updated Jun 17, 2026 · Updated 24 times

Summary

This study tested an experimental drug called EG-501 for people with lupus who experience cognitive impairment, often called "brain fog." The trial involved 131 participants who received either the drug or a placebo over 14 weeks. The goal was to see if EG-501 could safely improve memory and thinking skills, as measured by a standard cognitive test.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • UT Health Houston

    Houston, Texas, 77030, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

The condition(s) this trial relates to.

central nervous system lupus Cognitive Dysfunction systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.