Substance-related disorder

This trial tests whether extra support from peer recovery specialists can help young adults aged 18 to 25 stay in outpatient substance use treatment. Participants receive four weekly sessions plus monthly check-ins focused on motivation and skills to improve attendance. Researche…

This study tests whether a virtual reality experience, where people see an avatar that looks like them in a park, can help those in early recovery from stimulant use reduce drug use and stay abstinent longer. Researchers will compare this VR experience to a plain VR park without …

This trial tests whether a structured improvement strategy, called SAIA, can help syringe service programs in the U.S. deliver more HIV testing and referrals to prevention and treatment services. The study will compare programs using SAIA with those continuing their usual practic…

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This study tests a mobile app called Connections for people living with HIV who also have substance use disorders. The app provides resources, weekly check-ins, discussion rooms, and private messaging with peer mentors and care teams. Researchers want to see if using the app help…

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This trial tests whether adding substance use disorder resources to existing behavioral health services in pediatric primary care clinics can improve care for adolescents with opioid use disorder. The approach includes training, stigma reduction, and brief interventions during re…

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This study tests whether a telehealth-delivered counseling program, called VetReach, can help veterans with opioid use disorder engage in treatment and improve their outcomes. The program combines motivational interviewing and cognitive behavioral therapy, delivered remotely. Res…

This study tests a program called Just Care for Families, designed to help parents in rural Oregon who are involved with child welfare services and struggle with opioid or methamphetamine use. The program combines substance use treatment, mental health support, parenting training…

This study tests whether a brief screening and a telehealth counseling session in the emergency department can help people reduce their use of drugs or alcohol. About 650 adults who are at low or moderate risk for substance use problems will take part. The goal is to see if this …

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests a specially designed psychological treatment module for men in Pakistan who struggle with both depression and substance use disorders. The module combines several therapy approaches and is culturally adapted. Half of the participants receive this 12-session progr…

This study tests whether combining one-on-one financial coaching with access to safe, affordable banking services can improve both financial health and mental well-being for people recently released from jail or prison. Participants, who self-identify as having mental health or s…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This study tests a trauma-informed program called TRUST for women leaving prison who have a history of substance use and violent victimization. The program includes individual and group sessions to build skills and support recovery. Researchers will measure changes in substance u…

This study tests whether using a dried blood spot test (a simple finger prick) can help people with hepatitis C start treatment faster than the usual method that requires a blood draw. The trial involves 141 participants who work with a peer support program and telemedicine. The …

This study tests a computer alert that reminds doctors to prescribe naloxone—a drug that reverses opioid overdoses—alongside high-risk opioid prescriptions. The alert appears when a doctor orders an opioid for patients aged 12-89 (excluding those with cancer or hospice care). Res…

This study tests whether a combination of weekly video-counseling sessions and a mobile app can help young adults (18-29) living with HIV achieve viral suppression. Participants who are not virally suppressed will be randomly assigned to receive the intervention or standard care.…

This study tests a program called Khanya, where trained peers (people with lived substance use experience) help HIV patients stick to their medication and reduce drug or alcohol use. The program is offered in steps: a basic version first, then a more intensive one if needed. Rese…

This study tests whether a collaborative care model—where a nurse care manager works with your primary care doctor and an addiction specialist—can help adults reduce their use of opioids, stimulants (like cocaine or meth), and heavy drinking. About 300 patients from primary care …

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study looks at whether a therapy called RRFT, which treats substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with both conditions will be randomly assigned to RRFT or usual care, and tracked for a year. The …

This study looks at two different approaches to help community hospitals start treating opioid use disorder in patients. One approach is basic training and education, while the other adds extra support like practice facilitation. The goal is to see which method works better at ge…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests whether offering financial rewards can help people with schizophrenia, bipolar disorder, or substance use disorder stick to their long-acting injectable medication after being forced into the hospital. About 1,000 participants will be randomly assigned to receive…

This study compares two approaches to help people who are homeless or at risk of homelessness quit smoking: cytisine (a plant-based pill) versus nicotine replacement therapy (like mouth spray, patches, or gum). Both groups also get counseling. The goal is to see which strategy wo…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This study tests whether a personalized program—including patient navigation, individual health benefits, and financial help—can reduce deaths from preventable causes like heart attacks, strokes, heavy drinking, and HIV in low-income adults aged 35–64. Researchers will track chan…

This study tests whether a smartphone app that connects people in recovery from opioid use disorder with peer supporters can help them stay on track. About 1,300 adults who own a smartphone and are in recovery or treatment will use the app or receive usual care. Researchers will …

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests a program called the Bridge Model that provides social support, volunteering, and job opportunities to help people with nicotine or substance use disorders who are homeless or low-income. Researchers want to see if this approach improves quality of life and helps…

This study tests a program called ED-LINC that starts in the emergency room for people with opioid use disorder. The program offers overdose education, motivation to seek help, help choosing medication, and three months of follow-up care. Researchers want to see if this approach …

This study tests whether a special care team that combines treatment for severe injection-related infections and substance use disorders can improve outcomes. 480 hospitalized adults who inject drugs will either receive this integrated care or usual treatment. The main goal is to…

This study tests a therapy program called MIO-CPP for mothers recovering from substance use disorders and their young children (up to age 5). The program combines individual therapy for mothers and joint mother-child sessions to strengthen their bond and improve child well-being.…

This study aims to eliminate hepatitis C among people who use drugs in Paris, Marseille, Lyon, and Fort-de-France. Researchers will screen participants, provide immediate treatment, and use a peer-referral system to reach more people. The goal is to see if this community-based ap…

This study tests whether adding a communication skills video and a substance use module to standard couples HIV testing can help male couples reduce drug use and risky sex. About 484 male couples are randomly assigned to receive standard testing alone or with one or both extra mo…

This study tests two counseling programs to help women who use drugs in Tanzania start and stay on PrEP, an HIV prevention pill. 200 women will be randomly assigned to receive either brief motivational counseling, the same plus extra mental health support, or standard information…

This study tests whether a drug prevention program called Project ALERT, combined with a support tool called Getting to Outcomes, can reduce substance use among 7th and 8th graders. Researchers will track students' alcohol, cigarette, marijuana, and other drug use, as well as the…

This pilot study tests a family-based program called Modified Family Talk, designed to help prevent substance use in teenagers aged 12-18 whose parents are in recovery from substance use disorder. The program consists of six sessions over 12 weeks, aiming to strengthen family res…

This trial tests whether a digital app called FostrSpace can reduce substance use among youth aged 13 to 20 who are in foster care. The app is delivered through training sessions for CASA volunteers, who then support the youth in using it. Researchers will measure changes in drug…

This study tests a 9-month mentoring program for 8th and 9th graders who have experienced child abuse or neglect and are involved with child welfare. The program pairs teens with graduate student mentors who help them set goals in relationships, education, activities, career, and…

This study tests a digital program called BrotherlyACT designed for young Black males aged 15-24 who have experienced trauma. The program includes life skills coaching, safety planning, and an AI chatbot to help reduce violence and substance use. 300 participants will be split in…

This trial tests a school-based program called PreVenture, which uses brief workshops tailored to teens' personality traits to prevent substance use disorders. Over 12,500 students across Canada are taking part. The goal is to see if this approach can delay or reduce drug and alc…

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

Researchers are testing a personalized, non-drug treatment for adults with ongoing depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Instead of assigning treatment by diagnosis alone, the study selects approaches base…

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This pilot study tests whether a 4-week virtual mindfulness-based group intervention with social support is feasible and acceptable for pregnant individuals at higher risk for substance use. Participants join weekly video conference groups focused on grounding, thinking patterns,…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This trial tests a 12-session cognitive-behavioral therapy designed to help people with substance use who also struggle with anxiety or depression. The therapy focuses on improving emotion regulation—the ability to understand and manage emotions—which may reduce addictive behavio…

This study asks whether standard residential treatment for substance use disorders can improve a person's ability to empathize with others. Researchers will measure empathy levels in about 108 adults before and after they complete a residential program followed by partial hospita…

This study tests whether a self-help handbook called the 5-Step Method can help family members cope with the stress of a relative's drug or alcohol misuse. 24 adults in the US will be split into two groups: one gets the handbook, the other does not. The goal is to see if the prog…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study compares a text message-based mental health and substance use screening program (Listening to Women & Pregnant and Postpartum People) to standard in-person screening. Over 10,000 pregnant and postpartum people will participate. The goal is to see if the text-based appr…

This study looks at whether adding a structured therapy journal to standard cognitive behavioral therapy (CBT) helps people with mental health conditions like depression, anxiety, or eating disorders feel better faster. About 80 adults in outpatient therapy will be randomly assig…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This early study tests whether vaporized cannabigerol (CBG) and THC can help with pain and appetite. Twenty occasional cannabis users will receive different doses of CBG and THC, alone or together, and report their pain tolerance, hunger, and any side effects. The goal is to see …

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

Researchers are running a long-term observational study to see whether changes in clinical measurements over time can predict meaningful patient outcomes better than a single snapshot. The study will enroll about 1,000 adults and follow them, collecting routine clinical data, lab…

This study tests whether methylphenidate (Ritalin) can help weaken memories that link drug cues to cocaine use. Fifty-one adults with cocaine use disorder will receive either methylphenidate or a placebo before recalling drug-related memories, while brain activity and skin respon…

This pilot study tested whether a 'care navigator' could help people with substance use disorders follow through on treatment plans. The navigator worked alongside usual care coordinators to address barriers like language, income, or location. The study involved 74 patients and f…

This observational study follows pregnant women with opioid use disorder who are taking buprenorphine or methadone. Researchers use MRI scans of the placenta and fetal brain during the second and third trimesters, along with blood samples and developmental assessments after birth…

This study tests whether a coaching program called COSTARS helps child welfare supervisors better support their teams, including caseworkers and peer mentors with lived recovery experience. About 200 supervisors in Ohio's START program will either receive coaching or continue usu…

This study looks at how harm reduction care (a non-judgmental approach to drug use) in HIV clinics affects stigma and health outcomes for people living with HIV who use drugs. Researchers will survey 768 patients and providers to understand how attitudes and care practices influe…

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to g…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This study tests whether telehealth programs can help people manage their alcohol use and improve well-being. About 300 adults with alcohol use disorder will join remotely via video or phone. They will be split into two groups: one gets a telehealth program, the other gets usual …

This study looks at whether counseling sessions done over video call (telehealth) are practical and well-liked by people with substance use disorder who are not currently getting treatment. About 50 participants will try the program and share their feedback through surveys. The g…

This observational study at Yale uses PET brain scans to measure CB1 receptor availability in 15 people who currently use synthetic cannabinoids. Researchers want to see if these receptors are lower in users and how that relates to thinking skills and brain rhythms during withdra…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study aimed to understand how a person's socioeconomic status (like income and education) affects their recovery from substance use disorder. Researchers planned to follow adults in early recovery for up to 3 years, measuring changes in social functioning, quality of life, a…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This study looks at how to help primary care clinics screen more adults for substance use problems. It compares different support strategies like coaching, team learning, and financial rewards. 144 clinic staff from 48 practices will take part. The goal is to find the best way to…

This study tests a training program called PATH, designed to help peer recovery support specialists who deliver harm reduction services. The program includes online lessons and group meetings to discuss real-life cases. Researchers want to see if it reduces burnout and improves t…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study tests a new program to make it easier for people living with HIV to get screened for substance use disorders. The program uses online patient portals and in-clinic tools to find those who need help and connect them to treatment. Researchers will track how many people g…

This study tests whether a "Care Navigator" — a personal guide — can help people with substance use problems start and stay in treatment. About 360 adults who call a mental health access center will be randomly assigned to get usual care or extra help from a navigator. The goal i…

This study was designed to test whether a mobile app with personalized feedback and peer coaching could help young adults aged 18-29 who drink heavily and have experienced interpersonal trauma. Participants would have been randomly assigned to the enhanced app or a standard versi…

This study tests whether giving doctors brief education and feedback on their opioid prescribing habits leads to safer prescribing. About 52 primary care clinics are involved. The goal is to reduce inappropriate opioid use and lower the risk of addiction.

This study aimed to see if adding patient questionnaires, staff training, and telemedicine could improve mental health and substance use disorder care for people living with HIV. It was planned for five clinics in Alabama, but the trial was withdrawn before enrolling any particip…

This study follows 117 young adults (ages 23–28) who were part of a previous study since adolescence. Researchers use brain scans and surveys to understand how changes in the brain relate to smoking, drinking, and drug use. No treatment or medication is involved—only observation …

This study aims to improve how overdose fatality review teams work by giving them a data dashboard and training. Instead of reviewing just one or two cases at a time, teams will use near real-time data to spot patterns and make better recommendations. About 400 team members and l…

This study aimed to see if a non-invasive brain stimulation technique called TMS could help people with methamphetamine use disorder control their cravings. Researchers planned to recruit 40 adults living in a residential treatment program and give some real stimulation and other…

This study looks at whether giving staff bonuses for hitting targets helps them deliver better substance use counseling to people with HIV. Researchers are comparing two strategies: one with just training and feedback, and another that adds monetary incentives. The goal is to see…

This early study is testing whether focused ultrasound, a non-invasive technique that uses sound waves to target specific brain areas, is safe and feasible for people with opioid or other substance use disorders. The study involves 20 adults aged 22-60 who are currently in treatm…

This study looks at how people's bodies react to stress in a pretend emergency room. Researchers will have 30 adults (20 who use meth and 10 healthy volunteers) do public speaking and math tasks while measuring stress hormones, heart rate, and blood pressure. The goal is to see i…

This study aimed to see if a brain training method called ZQLN could improve brain activity and thinking skills in people with cocaine use disorder. It planned to enroll adults aged 21 to 51 who had completed detox. However, the study was withdrawn before any participants were en…

This study looks back at 376 patients who received psychedelic-assisted therapy with LSD or psilocybin for depression, anxiety, PTSD, or substance use disorders. Researchers want to see if the intensity of the psychedelic experience is linked to better outcomes. All data comes fr…

This study follows 400 adults receiving standard treatment for prescription narcotic drug use disorder, including opioids and benzodiazepines. Researchers will measure how many patients reduce or stop using these drugs and what factors help. No new treatments are tested; the goal…

This study follows 120 people in group therapy for alcohol use disorder to see which patient factors—like mental health, drinking severity, personality, or thinking skills—predict who finishes treatment and stays sober a year later. Researchers hope to learn how to match patients…

This observational study looks at a newly identified lung condition called histiocytosis in people who inject drugs. Researchers will study 30 patients to understand symptoms, diagnosis, and outcomes. They will also test new ways to detect a substance called polyvinylpyrrolidone …