Cannabis compounds CBG and THC tested for pain and hunger boost
NCT ID NCT04859296
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tests whether vaporized cannabigerol (CBG) and THC can help with pain and appetite. Twenty occasional cannabis users will receive different doses of CBG and THC, alone or together, and report their pain tolerance, hunger, and any side effects. The goal is to see if these compounds are safe and effective for these symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cannabigerol (CBG) and Delta-9-tetrahydrocannabinol (THC) vaporized
- What this could lead to
- If it works, this could point toward a treatment for pain and appetite loss using cannabis compounds.
- What could go wrong
- This is a very small, early-phase study with only 20 participants. Results may not apply to everyone, and the compounds may cause intoxication or abuse potential.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Feb 2023
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
21 to 55 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or non-pregnant and non-lactating females aged 21-55 years * • Report occasional use of cannabis (cannabis use between ≥ biweekly and ≤ 3 days per week) over the month prior to screening * Not currently seeking treatment for their cannabis use * Have a Body Mass Index from 18.5 - 34kg/m2. * Able to perform all study procedures * Must be using a contraceptive (hormonal or barrier methods) * Females must not be lactating Exclusion Criteria: * Meeting DSM-V criteria for moderate-severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine, or mild CUD * Any other Axis I disorder * • Current use of any medications within 14 days or 5 half-lives of administration (whichever is longer) except for hormonal contraceptives in females. If a medication is taken once a participant is enrolled, sessions will be suspended for 14 days or 5 half-lives after administration (whichever is longer) * If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process are not within the normal range and / or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures. * Current pain * Pregnancy is exclusionary due to the possible effects of the study medication on fetal development. * History of an allergic reaction or adverse reaction to cannabis is exclusionary. * History of respiratory illness or current respiratory illness * Currently enrolled in another research protocol * Not using a contraceptive method (hormonal or barrier methods) * Insensitivity to the cold water stimulus of the Cold Pressor Test * Any disorders that might make cannabis administration hazardous are exclusionary, as determined by the evaluating physician
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Abuse, drug are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of California, Los Angeles
Los Angeles, California, 90095, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Five simple signs could help nurses score surgical pain in turkish
- Can green light glasses take the sting out of surgery?
- Can a Hands-On nerve technique ease Fibromyalgia's grip?
- Fixing broken ribs with surgery may cut pain better than drugs alone
- Could a Patient's playlist take the sting out of nerve testing?
- Scientists probe the mental steps behind rating your pain