Acute coronary syndrome

Researchers are testing whether adding bempedoic acid to high-intensity statin and ezetimibe therapy within 72 hours after a heart procedure helps adults with acute coronary syndrome reach very low LDL cholesterol. Participants receive either the three-drug combination or the sta…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a sh…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This study looks back at medical records of heart attack patients with a large clot in a coronary artery. It compares two ways to reopen the blocked artery during emergency angioplasty: a drug-coated balloon that delivers medication and is then removed, versus a drug-eluting sten…

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This trial tests whether starting a comprehensive, guideline-based treatment plan immediately after a heart attack can reduce the chance of another heart attack, stroke, or death. The plan targets key risk factors like high cholesterol, high blood pressure, and diabetes using a c…

This study looks at whether taking just one blood thinner (a P2Y12 inhibitor) is as safe and effective as taking two blood thinners (dual antiplatelet therapy) for people with stable heart disease who have a drug-coated balloon procedure without a stent. About 2,170 adults will b…

This trial tests whether adding a low-dose blood thinner (rivaroxaban) to standard antiplatelet therapy for the first three months after a heart stent procedure can reduce the risk of future heart attacks, strokes, and other cardiovascular events in high-risk patients. Participan…

This study compares two medicated stents (tiny mesh tubes) used to open blocked heart arteries in people having a heart attack or unstable angina. About 2,100 participants will receive either a sirolimus-eluting stent (ihtDEStiny) or an everolimus-eluting stent (Xience). Research…

This phase III trial tests whether vicagrel, an experimental antiplatelet drug, can prevent major heart-related events better than the standard drug clopidogrel in people with acute coronary syndrome (such as a heart attack or unstable angina) who are undergoing a stent procedure…

This study tests whether combining three standard heart medications (aspirin, a blood thinner, and a statin) into a single daily pill helps people who've had a heart attack take their medicine more consistently. About 1,000 adults who recently had a heart attack and a stent place…

This study tests whether adding resilience training—a mix of group therapy and relaxation exercises—to standard rehabilitation helps people recover from Takotsubo cardiomyopathy (broken heart syndrome) or a recent heart attack. Participants attend two group therapy sessions and t…

This study compares two treatments for people with severe blockages in multiple heart arteries who are having a heart attack without ST elevation. One treatment is stenting (a tube to open arteries), the other is bypass surgery (rerouting blood flow). The goal is to see if stenti…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed for people with long blockages in their heart arteries. The goal is to see if the stent is safe and works well at keeping arteries open for up to 12 months. About 100 pa…

This early-stage trial tests whether an experimental drug called UDP-003 is safe in healthy volunteers and people with heart disease. Researchers will give single or multiple doses of the drug or a placebo and monitor for side effects. The study includes 84 participants and is th…

This pilot study tests whether the drug colchicine can reduce artery plaque in 120 heart attack survivors who have a specific genetic change (TET2-CHIP). Participants take colchicine or standard care for 12 months. The goal is to see if this genetic marker can guide personalized …

This study tests whether a digital support program (called DEEPER) helps heart patients maintain their health after completing cardiac rehab. About 306 adults with heart disease or heart failure will be split into two groups: one gets standard follow-up care, the other gets stand…

This early-stage trial compares a new investigational drug, CG-0255, to the established blood thinner Plavix in 136 healthy adults aged 18-55. The goal is to see if CG-0255 is processed by the body similarly to Plavix and has the same effect on preventing blood clots. Participant…

This phase 3 trial tests whether the drug dalcetrapib can reduce the risk of major heart problems like heart attacks in people who have a specific genetic makeup (AA genotype) and have recently had a heart-related event. About 2,000 participants will receive either dalcetrapib or…

This study looks at whether adding oregano and basil leaves to the diet can lower inflammation and improve cholesterol in people who have recently had unstable angina. About 70 participants will eat these herbs and have their blood and urine tested. The goal is to see if these co…

This study tests whether a two-drug combination of dabigatran and ticagrelor can lower bleeding risk compared to the standard three-drug therapy (dabigatran, clopidogrel, and aspirin) in people with atrial fibrillation who have had a heart stent after a heart attack. About 1,200 …

This study tests whether adding evolocumab, a cholesterol-lowering drug, to standard care can slow or stop plaque buildup in heart arteries after a heart attack. About 233 adults aged 40-75 who recently had a heart attack or unstable angina will receive either evolocumab plus sta…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study tests whether a heart rehab program that combines telehealth sessions at home with some clinic visits helps more people stick with it and improve their fitness compared to the standard all-clinic program. About 250 adults who had a heart attack or related condition in …

This study looks for the best type and dose of blood thinner (P2Y12 inhibitor) for people who have had a heart stent placed. After an initial period on two blood thinners, patients switch to one. The goal is to find a dose that keeps blood clotting at a safe level—not too high (w…

This study tests whether tailoring exercise to feel more pleasurable can help heart attack survivors stay active. Fifty-two patients will either follow a standard cardiac rehab program or one where exercise intensity is adjusted to maximize enjoyment. Researchers will measure phy…

This study compares two medical devices used to break up hard calcium deposits in heart arteries before placing a stent. It involves 50 adults with coronary artery disease who will be randomly assigned to receive either orbital atherectomy or intravascular lithotripsy. The goal i…

This study looks at two ways to treat blocked heart arteries in people aged 18 to 68. One uses a drug-coated balloon, and the other uses a temporary scaffold. The goal is to see which approach works better over time, with fewer heart problems or need for repeat procedures. About …

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This early-stage trial tests an injectable drug called IMC-001 in 18 people who recently had a heart attack or unstable angina. The goal is to see if it can safely stabilize fatty plaques in the arteries, making them less likely to cause future heart problems. Participants are ra…

This study compares two blood-thinning approaches in 326 adults with acute coronary syndrome and coronary artery ectasia (enlarged heart arteries). One group gets standard dual antiplatelet therapy (aspirin plus clopidogrel), while the other gets clopidogrel plus the anticoagulan…

This study looks at two types of stents (small mesh tubes) placed in heart arteries to keep them open. It focuses on patients with acute coronary syndrome who also have a high risk of bleeding. The goal is to see how well the blood vessel heals around the stent one month after th…

This study tests a new device that freezes dangerous plaque in heart arteries to see if it can reduce blockages and prevent future heart problems. About 30 people with stable angina or recent heart events will receive the freezing treatment during a planned procedure. Researchers…

This study compares two ways to guide heart stent placement in people with acute coronary syndrome (unstable angina or heart attack). One method uses standard X-ray images (angiography), and the other adds an ultrasound probe inside the artery (IVUS) for more detail. About 1,500 …

This study compares two blood thinner combinations in adults over 65 who have had a heart attack or unstable angina and received a stent. One group gets indobufen plus ticagrelor, the other gets aspirin plus ticagrelor. The goal is to see which combo better prevents heart-related…

This study tests whether a reduced dose of the blood thinner prasugrel (5 mg), taken alone without aspirin, is safe and effective for patients who have had a stent placed for heart disease. Researchers will compare this approach to standard dual antiplatelet therapy (aspirin plus…

This study is testing a special balloon coated with the drug sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to push the blockage aside and release the drug, which helps prevent the artery from narrowing again. Researchers will follow over 1,1…

This study tests using a drug-coated balloon instead of a permanent stent to open blocked arteries during a heart attack. The balloon delivers medication to prevent re-blockage without leaving a metal implant. Researchers will track 300 participants to see if this approach is saf…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent heart attacks and strokes in people at risk. About 130 adults aged 40-75 who are in the ER for possible heart issues will receive guideline-based care. The goal is to low…

This study tests if taking colchicine (an anti-inflammatory drug) along with a single blood thinner (ticagrelor) right after a heart attack stent is safe and works well. About 490 adults who had a heart attack and received a specific type of stent will participate. The goal is to…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. Participants receive either orticumab or a placebo for 24 weeks. The main goal is to see if orticumab lowers inflammation measured by a special …

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study tests whether a drug-coated balloon can reduce fatty deposits in heart arteries better than standard medications alone. Researchers will enroll 400 adults who recently had a heart-related event (acute coronary syndrome). Participants will get either the balloon treatme…

This study looks at whether a genetic test can help choose a safer blood thinner for people who have had a heart attack. After one month on two blood thinners, some patients will switch to a single, lower-potency drug based on their genetic profile. The goal is to see if this app…

This study tests whether a new pressure microcatheter works as well as the standard pressure wire for guiding stent placement in people with coronary artery disease. About 2,500 participants will be randomly assigned to one of the two devices during their procedure. The main goal…

This study tests whether rapidly adjusting cholesterol-lowering medications, based on frequent blood tests, helps heart disease patients reach their LDL cholesterol targets faster. Researchers will enroll 1000 adults with coronary artery disease and monitor their cholesterol leve…

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study looks at whether taking two blood thinners (ticagrelor plus aspirin) is better than aspirin alone for keeping bypass grafts open in people who had heart surgery after a heart attack. About 360 participants will be followed for 1 to 3 years, and their grafts will be che…

This study tests whether briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with congestive heart failure. About 240 participants will be randomly assigned to receive either the real cuff inflations or a sham ve…

This study tests whether placing stents in non-blocking but unstable heart plaques, along with intensive medication, reduces heart attacks and other cardiac events better than medication alone. About 2,190 adults with acute coronary syndrome will be randomly assigned to either st…

This study follows 500 people who already have or will get the AngelMed Guardian® implant, a device that monitors heart signals and alerts patients to possible heart attacks. Participants are high-risk heart patients with conditions like diabetes or prior heart attacks. The goal …

This study looks at 2,600 heart attack patients who had a stent placed and also have an H. pylori infection. Half will get a 2-week course of vonoprazan plus amoxicillin to treat the infection, while the other half gets a standard 6-month acid blocker (pantoprazole). The goal is …

This study tests whether a risk score (OPT-CAD) can safely guide how long heart attack patients need to take two blood thinners after getting a stent. About 3,490 participants will either follow standard 12-month dual therapy or have their therapy reduced to one blood thinner ear…

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

Paramedics and other prehospital providers often interpret ECGs under time pressure without expert backup. Missing a blocked coronary artery delays life-saving treatment, while false alarms send patients for unnecessary procedures. This trial randomizes 144 prehospital providers …

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study looks at whether a simple blood test done in the ambulance can safely rule out a heart attack in people with chest pain. Many patients are taken to the hospital even though they are not having a heart attack. The test uses a portable device to measure a heart protein c…

This study explores whether performing a cardiac MRI (CMR) before the standard invasive coronary angiography (ICA) can accurately diagnose the cause of a suspected non-ST-elevation heart attack (NSTEMI). Currently, patients with NSTEMI often undergo an invasive angiogram, and if …

This study tests whether an AI tool that reads ECGs can safely and effectively help emergency doctors decide if a patient with chest pain is having a heart attack. About 4,670 adults with chest pain suspicious for a heart attack will be randomly assigned to either AI-assisted or …

This study tests whether a lab technique called polyethylene glycol (PEG) precipitation can tell the difference between a true heart attack and a harmless condition called macrotroponin, where troponin molecules clump together and falsely signal heart damage. Researchers will com…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study will test a new, more accurate blood test (Troponin T high-sensitivity Gen 6) to see if it helps doctors diagnose heart attacks faster. Researchers will compare emergency department visit data from 19,500 patients before and after the test is introduced. The goal is to…

This study is testing whether artificial intelligence (AI) can predict or rule out a heart attack using data from standard blood tests. Researchers will analyze white blood cell properties from over 3,000 adults who come to the hospital with chest pain. The goal is to see if AI c…

This study tests whether an artificial intelligence (AI) tool can help doctors identify heart attacks that standard ECG tests miss. About 500 adults with chest pain but no clear signs of a heart attack on their initial ECG will be randomly assigned to get either AI-assisted or st…

This study tests a new, quick blood test done right in the emergency room to rule out heart attacks in people with chest pain. The goal is to see if this faster test can get patients discharged sooner compared to the usual lab test, which can take an hour or more. About 1,500 adu…

This study looks at a new technology called Cor-IS that measures how well blood vessels widen (flow mediated dilation) in people who have had a heart attack. Researchers will compare it to the standard FMD test and track patients for future heart problems. The goal is to see if C…

This study tests a new, noninvasive device that uses ultra-sensitive magnetocardiography to detect heart attacks. Researchers will enroll nearly 4,000 healthy volunteers and chest pain patients to see if this magnetic scan can identify heart damage more accurately than current me…

This study aims to see if a new device called magnetocardiography (MCG) can quickly and accurately detect blocked arteries in people with suspected heart attack symptoms. Researchers will compare MCG results with standard tests in about 14,000 adults. If successful, MCG could hel…

This study tests a new CT scan that works without an ECG to quickly check for heart disease in people with chest pain and high troponin levels. About 230 adults will get this scan plus the standard invasive test to see if the new method is accurate. If successful, it could reduce…

This study tests if fexuprazan can prevent upper stomach bleeding in 400 heart patients at high risk for bleeding who must take two blood thinners after getting a heart stent. Participants receive either fexuprazan or the standard drug lansoprazole daily for 6 months. The goal is…

This study tests whether getting a flu vaccine can prevent serious heart problems in people who have recently had a heart attack or unstable angina. About 6,620 participants will receive either a flu shot or a placebo and be followed for one year. The goal is to see if the vaccin…

Acute coronary syndrome, which includes heart attacks, often triggers intense anxiety during the rush to hospital. Researchers are testing whether playing music for 20 minutes in the ambulance, on top of usual care, lowers anxiety and pain more than usual care alone. The trial en…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce depression symptoms in people who have had a heart attack or related heart problem and a stent placed. About 120 adults will use the device at home for 8 weeks, and their mood…

This study looks at whether a special sequence of gentle exercises called Baduanjin can improve heart and lung function and quality of life in people who have both acute coronary syndrome and heart failure. About 65 participants will either do these exercises plus standard care o…

This study tests a 12-week program that combines positive psychology and motivational interviewing to help people who have had a heart attack become more physically active. The program is delivered remotely via phone and text messages. Researchers will compare activity levels and…

This study is testing whether a single intravenous dose of iron can improve quality of life and reduce frailty in adults aged 65 and older who have iron deficiency after a heart attack. About 538 participants will be randomly assigned to receive either the iron infusion or standa…

This study tests whether using a hand fan can prevent or reduce shortness of breath caused by the heart drug ticagrelor. About 110 adults with acute coronary syndrome who are starting ticagrelor will be enrolled. Researchers will track how many people have breathing trouble withi…

This study tests whether an online cognitive behavioral therapy (CBT) program can reduce heart-related anxiety in people who have had a heart attack or unstable angina. 176 participants will be randomly assigned to either the CBT program or a digital lifestyle advice group. The g…

People admitted for acute coronary syndrome, which includes heart attacks and unstable angina, face a higher risk of dangerous heart rhythms such as sustained ventricular tachycardia and ventricular fibrillation. Hospitals monitor these patients, but the exact rate of these rhyth…

This trial tests whether using a risk score and a rapid blood test in the ambulance can help decide where to take patients with chest pain. About 1,048 adults at intermediate or high risk for a heart attack will be randomly assigned to either this new triage method or usual care.…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This study is testing a new bedside device called CardiAQ MCG that measures the heart's magnetic fields to detect blocked arteries (ischemia). Researchers will enroll 150 adults scheduled for heart catheterization to see if the device can accurately predict heart attack status. T…

This observational study aims to uncover clinical and genetic risk factors for sudden cardiac arrest and death in patients with coronary artery disease (CAD). Researchers will follow about 4,000 participants who have been diagnosed with CAD, collecting data from surveys, ECG reco…

This study will observe 500 adults with stable or acute heart artery disease who receive a laser treatment called Excimer Laser Coronary Atherectomy (ELCA) during a standard procedure to open blocked arteries. The goal is to track how well the laser works and how safe it is by re…

This study is a registry that collects information from all suspected heart attack cases in Tomsk, Russia. It aims to track how many people die within 28 days and one year after a heart attack. No new treatments or drugs are being tested—just observation and data gathering.

This study investigates whether blood sugar patterns, measured continuously with a wearable sensor, can predict serious heart problems in the year following a heart attack. Researchers will enroll 850 people hospitalized with acute coronary syndrome and track their glucose levels…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study looks at 1,500 adults with suspected acute coronary syndrome but no clear ST elevation on their ECG. Researchers will test whether an artificial intelligence model can correctly identify those who actually have a blocked artery (occlusion myocardial infarction). They w…

This study looks at 60 adult male smokers under 65 who have both heart disease (acute coronary syndrome) and pneumonia along with COPD. Researchers want to see if certain blood markers (GDF-15, MR proADM, and Presepsin) change after getting a flu shot. The goal is to understand h…

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study looks at immune cells called macrophages in the arteries of people with heart disease or poor leg circulation. Researchers will use imaging and blood tests to see how these cells are activated. The goal is to better understand the disease, not to test a new treatment. …

This study examines how frailty and other health factors affect the short- and long-term outlook for people aged 75 and older who are hospitalized for a heart attack or unstable angina. Researchers will compare two treatment approaches—a procedure to open blocked arteries versus …

This study looks at tiny particles called exosomes in the blood of 300 people who experienced sudden cardiac death after a heart attack. Researchers want to see if certain molecules in these particles can help predict who is at highest risk. The goal is to improve early warning a…

This study tests whether a rapid outpatient evaluation within 72 hours of an emergency department visit is as safe and effective as hospitalization for people with chest pain at moderate risk of a heart attack. About 500 participants will be randomly assigned to either outpatient…

This study is creating a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic, biochemical, and molecular data to understand how symptoms and disease patterns may vary among women. The goal is to identify subtypes of heart disease…

This study follows 20,000 heart attack patients who are discharged early from the hospital after a minimally invasive procedure. Researchers want to see how well medications are adjusted, track major heart events, and measure quality of life over one year. No new treatment is giv…

This study examines gut health in 15 adults aged 30-70 who have had a heart attack or unstable angina. Researchers will measure gut permeability and bacteria imbalances at the start and after 24 hours. Then, they will test if special essential oils can restore healthy gut functio…

This study tests a dynamic coronary roadmap system that helps doctors guide a pressure wire into narrowed heart arteries. 226 patients with ischemic heart disease will be randomly assigned to have the procedure with or without the roadmap. The main goal is to see if the roadmap r…

This study looks at 200 people having a heart attack to see if a special camera (OCT) inside the arteries correctly identifies the type of plaque that caused the attack. Researchers will compare the camera images with the actual plaque material removed during a standard procedure…

This study is collecting information from 11,000 people who have had a heart attack or heart muscle injury. Researchers want to learn more about these conditions to improve future treatment. The study does not test a new drug or procedure, but instead gathers data to better under…

This observational study enrolls 5,000 adults hospitalized with acute coronary syndrome in Italy. Researchers will track how often doctors follow European quality indicators, like timely artery-opening procedures and proper discharge medications. Participants are followed for 12 …

This study looks at whether people having urgent heart catheterization need to fast beforehand. 400 patients with chest pain or mild heart attacks will be randomly assigned to either fast as usual or eat and drink normally. Researchers will measure comfort and safety to see if sk…

This study reviews medical records of 200 adults who came to the ER with a heart attack or unstable chest pain. It compares what happens when patients get two blood thinners (aspirin plus another) in the ER versus waiting to give the second one in the catheterization lab. The goa…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…

This study looks at 1,600 people who recently had a heart attack to see if a common blood test (the neutrophil-to-lymphocyte ratio, or NLR) can help predict who is at higher risk of dying or having another heart problem within 6 months. Researchers will measure NLR from blood sam…

This study will follow 10,000 people who come to a clinic in Davos, Switzerland for cardiac rehabilitation after a heart attack, surgery, or other heart problem. Researchers will collect health data, blood samples, and genetic information to understand what helps people recover b…

This study is testing colchicine, an anti-inflammatory drug, in 380 people who have had a heart attack or unstable angina. Researchers want to understand why some patients respond well and others don't, by looking at their genes, proteins, and other markers. The goal is to build …