The University Of Hong Kong

This study tests whether a gel form of silver diamine fluoride works as well as the liquid form to stop cavities in preschool children. About 630 healthy children with at least one cavity will receive the gel or solution every six months for 30 months. The goal is to see if the g…

This study tests whether empagliflozin, a diabetes drug, can prevent liver scarring (fibrosis) from getting worse in people with chronic hepatitis B. About 106 adults with moderate to advanced liver scarring will take either the drug or a placebo daily for three years. The goal i…

This study tests whether a smartphone app can help Chinese adults with non-alcoholic fatty liver disease (NAFLD) lose weight over 12 months. Weight loss is currently the only proven way to reduce liver fat and prevent serious liver damage. The app provides health tips and trackin…

This study tests whether artificial intelligence can design dental crowns as well as a human technician. 40 adults with a damaged back tooth will receive either an AI-designed crown or a standard one. Researchers will check for cracks, loosening, and overall fit over time to see …

This study tests a new, non-invasive technique called histotripsy that uses high-intensity ultrasound waves to destroy liver tumours without cutting the skin. It aims to see if the treatment is safe and effective for up to 60 people with primary or secondary liver tumours. Partic…

This study tests whether the blood thinner dabigatran is as safe and effective as warfarin for preventing strokes in people with atrial fibrillation (irregular heartbeat) and moderate to severe mitral stenosis (narrowed heart valve). About 370 adults will take either dabigatran o…

This study tests whether an AI-powered mobile app can help older adults in Hong Kong improve their gum health. 88 participants aged 60 and older will receive personalized oral hygiene instructions based on photos of their gums analyzed by the app. Trained volunteers will provide …

This study tests a program called De-HF that helps heart failure patients and their family caregivers work together to manage the condition. The program includes both in-person and online support to improve quality of life and reduce hospital stays. About 232 patient-caregiver pa…

This study tests whether mobile health support (like text messages) and financial incentives can help older, low-income smokers in Hong Kong quit. About 1200 smokers aged 60 and above will be randomly assigned to receive one or both supports. Success is measured by breath and sal…

This study tests if a smart chatbot on WhatsApp can help smokers quit. Over 1,000 adult smokers in Hong Kong will either get usual advice or 12 weeks of chatbot support. The goal is to see if the chatbot leads to more people stopping smoking for good.

This study tests whether placing vancomycin powder directly into the wound during open back surgery can lower the chance of infection in high-risk patients (e.g., those with spinal deformities or tumors). About 76 adults will be randomly assigned to receive either standard care p…

This study looks at whether taking teriparatide for one month before lumbar fusion surgery helps screws grip stronger in patients with osteoporosis. The goal is to reduce complications like screw loosening. 192 participants will be randomly assigned to receive the drug or not, an…

This study tests whether smartphones can accurately detect atrial fibrillation (AF), a common heart rhythm problem, using built-in microphones, cameras, and small external sensors. About 209 adults with or without AF will have their heart sounds, electrical activity, and blood fl…

This study tests whether adding a special glass material to standard fluoride varnish can better prevent root cavities in adults over 60. Researchers will compare the two varnishes in 540 older adults over 36 months. The goal is to see which one reduces new cavities and helps sto…

This study tests whether a silver diamine fluoride (SDF) gel can prevent cavities in preschool children better than the usual fluoride varnish. About 1,500 healthy children will receive either the SDF gel or the varnish every six months for two years. The goal is to see which tre…

This study tests whether reading comics about tobacco can help primary school students learn about the dangers of smoking and develop anti-smoking attitudes. About 1,000 students in Hong Kong will either read comics or information sheets. Researchers will compare their knowledge,…

This study tests whether automated text messages teaching acceptance and commitment therapy can help older adults with mild cognitive impairment manage mood and behavioral symptoms. Forty participants will receive the text-based program or usual care. The goal is to see if this a…

This study tested whether a type of talk therapy for insomnia (CBT-I) can improve sleep and reduce ADHD symptoms in teens aged 11-18. 28 teens with both ADHD and insomnia took part. The goal was to see if better sleep leads to better mood and focus.

This study tests whether group cognitive behavioral therapy can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either anxiety-focused or insomnia-focused therapy. The goal is to see which approach better improves symptoms…

This study looks at whether exercising once a week or three times a week is better at reducing liver fat in adults with non-alcoholic fatty liver disease (NAFLD) who also have central obesity. Researchers will measure liver fat using special scans. The goal is to find the most ef…

This study looks at whether a special brain training method, called alpha neurofeedback, combined with computer-based cognitive exercises, can help children aged 6 to 18 who have had a brain tumor and now have trouble with attention or memory. Half of the 50 participants will get…

This study tests whether a personalized care plan, based on a geriatric assessment, can reduce severe side effects in older adults (65+) starting chemotherapy for common cancers. Participants are randomly assigned to receive the assessment-driven plan plus usual care, or usual ca…

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes combined with virtual reality (VR) goggles. The goal is to see if this training can reduce symptoms like inattention and hyperactivity…

This study looks at whether one session of a guided self-corrective exercise can immediately improve muscle activity and spine straightness in teenagers with idiopathic scoliosis. Forty adolescents aged 11 to 19 will have their back muscles and spine measured before and after the…

This study tests a smartphone-based program that gives new mothers real-time breastfeeding support at home. The goal is to help them breastfeed exclusively for longer and reduce stress and anxiety. 518 first-time mothers in Hong Kong will use the app during the first month after …

This study tests whether a mobile app called SUPPORT+ can help adults with advanced cancer feel better and avoid hospital visits. Participants use the app to report symptoms weekly, get self-care tips, and receive nurse follow-up for severe issues. The goal is to see if this digi…

This study tests whether combining a gentle brain stimulation technique (tDCS) with immersive virtual reality meditation can help reduce anxiety in people with Generalized Anxiety Disorder or similar conditions. About 52 adults will receive 12 sessions over two weeks, either real…

This study tests a program that helps people with mild dementia and their family caregivers work together using their strengths. The goal is to slow cognitive decline and improve caregivers' confidence. About 272 older adults and their caregivers will take part in this Hong Kong-…

This study tests a short, phone-based mindfulness and lifestyle coaching program for caregivers of people with brain diseases like Alzheimer's or Parkinson's. Many caregivers are inactive, raising their risk for heart disease and shortening their lives. The program uses text mess…

This study tests whether 3D-printed, custom-made titanium plates help surgeons rebuild the jaw more accurately and quickly than standard plates. About 92 adults with jaw tumors, deformities, or other conditions will be randomly assigned to receive either type of plate during surg…

This study tests whether an artificial intelligence (AI) tool can help medical students and doctors more accurately determine the stage and risk level of thyroid cancer. About 70 participants will review patient cases, some with AI help and some without. The goal is to see if the…

This study looks at whether a digital program called Digital Connect can help homebound older adults (age 65+) maintain their physical and mental health, and feel less lonely. Over 1,000 participants in Hong Kong will use the program, and researchers will measure changes in quali…

This study tests whether a nurse-led health coaching program helps women aged 45 to 64 in Hong Kong better manage common health issues like hot flashes, anxiety, and high blood pressure. About 1,728 women will either receive personalized nurse guidance or general health advice. R…

This study looks at how getting the flu vaccine year after year changes the body's immune response. Researchers will compare two types of flu vaccines in 600 adults aged 22-50 in Hong Kong. The goal is to understand why some people respond better to the vaccine and why it sometim…

This study tests a community parenting program called 'Amazing Start' for families with young children facing challenges like low income or single parenthood. About 270 families in Hong Kong are randomly assigned to receive the program or wait. The goal is to see if the program h…

This study is looking at CT scans of the heart from 22,000 people who had chest pain. Researchers want to see if certain features of plaque (fatty deposits) in the heart arteries can help predict who will later have a heart attack, stroke, or die from heart disease. The goal is t…

This study follows 54 adults with chronic hepatitis B who have been on long-term antiviral drugs and are now stopping treatment. Researchers want to understand the immune system and virus changes that happen after stopping, especially if a mild liver flare occurs. The goal is to …