The University Of Hong Kong

This study tests whether adding asciminib to standard therapy after a stem cell transplant can help prevent leukemia from returning in people with certain types of blood cancer (Ph+ B-ALL or blastic phase CML). About 45 adults will be randomly assigned to receive either the stand…

This study tests whether a digital-enhanced lifestyle program, led by trained volunteers, can improve muscle mass, strength, and reduce fall risk in older adults with sarcopenia (age-related muscle loss). About 200 people aged 60 and older will participate. The program focuses on…

This study tests a traditional Chinese medicine called Yulinzhu in 60 women aged 18-40 with diminished ovarian reserve (low egg supply). Participants take the herbal therapy for 12 weeks, and researchers measure changes in hormone levels and egg count. The goal is to see if the t…

This early-stage study will test whether a daily probiotic supplement containing bifidobacterium can reduce blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and their blood pressure will be measured at…

This study tests a new type of counseling designed to prevent young ex-smokers (ages 25 and under) from relapsing. About 100 participants who recently quit smoking will receive either the new personalized counseling or standard support. Researchers will check if the approach is p…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This study tests whether giving pembrolizumab (an immunotherapy) along with chemotherapy before surgery can help people with nasopharyngeal cancer that has come back. After surgery, patients continue pembrolizumab to keep the cancer away. The goal is to see if this approach can c…

This study tests whether taking capsules containing healthy donor stool (fecal transplant) can help clear a dangerous, antibiotic-resistant bacteria called CRE from the gut. About 80 hospitalized adults with CRE will receive either the capsules or a placebo. The goal is to see if…

This study tests a smartphone app that listens to heart sounds to detect congenital heart disease. Researchers will record heartbeats from 220 people (age 6+) and use the data to train artificial intelligence. The goal is to see if the app can tell the difference between normal h…

This study aims to see if a blood test that looks for genetic changes from tumors (ctDNA) can help find lung cancer earlier in people who have suspicious lung nodules on CT scans. Researchers will collect blood samples from 200 participants in Hong Kong and Vietnam at the start a…

This study will test if low-dose CT scans can help find lung cancer early and save lives in high-risk smokers aged 50-79. About 15,000 participants in Hong Kong will be randomly assigned to get the scan or usual care. The goal is to see if screening reduces deaths from lung cance…

This study aims to see if a program of fitness classes, lifestyle advice, and digital support can prevent osteoporosis (brittle bones) and sarcopenia (muscle loss) in adults aged 40 to 60. Over 8,300 participants will be split into two groups: one gets active coaching and exercis…

This study tests whether chewing xylitol gum for 4 weeks, along with text reminders, helps daily smokers cut down or quit. About 134 Hong Kong adults who smoke at least one cigarette daily will be split into two groups: one gets the gum and support, the other gets brief advice on…

This study tests a type of talking therapy called Cognitive Behavioral Therapy for Insomnia (CBTi) in 770 young people aged 12-24 in Hong Kong who have moderate mental distress and trouble sleeping. Participants will attend six weekly group sessions led by trained youth workers. …

This study tests if a special dental glue containing strontium-doped bioactive glass-ceramic can reduce tooth sensitivity. 142 adults with sensitive teeth will receive a single application of either the new glue or a standard glue. Pain levels will be checked right after and agai…

This study tests a 12-week program called EXCITE-PAC for family members caring for someone with dementia. The program uses counseling and group meetings to help caregivers find meaning and positivity in their role. Researchers will measure changes in caregivers' well-being, confi…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises as effectively as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receives standard physio sessions, the other uses…

This study tests a special type of acupuncture (DCEAS+BA) in 148 teens aged 15-22 who have mild to moderate anxiety or depression. Participants get either the real treatment or a sham version twice a week for 8 weeks. Researchers will measure changes in anxiety, depression, sleep…

This early study tests whether a weight loss drug (semaglutide, a GLP-1 receptor agonist) can help obese patients have less pain and fewer complications before and after total knee replacement surgery. About 54 adults aged 40-80 with a BMI of 27 or higher will take the drug or re…

This study tests if acupuncture can lower pain and the need for painkillers after hemorrhoid removal. About 100 adults having surgery for severe hemorrhoids will get either real acupuncture or a sham version over 5 days. Researchers will track pain levels, medication use, and rec…

This study tests a 5-week digital breathing program (heart rate variability biofeedback) to see if it improves well-being in people with first episode psychosis. 80 participants will either do the breathing exercises or listen to music. The goal is to reduce symptoms like depress…

This study tests whether dapagliflozin, a drug used for diabetes, can improve exercise ability and heart function in people who have had the Fontan procedure (a surgery for a single-ventricle heart defect). About 30 adolescents and adults will take the drug daily for 3 months. Th…

This small pilot study will test whether an 8-week group mindfulness program can reduce stress, anxiety, depression, and insomnia in parents who care for children with autism or ADHD. Thirty Chinese caregivers will attend weekly sessions and complete surveys before and after the …

This study tests whether a non-invasive brain stimulation technique called rTMS can improve movement and coordination in children with cerebellar ataxia, a condition that affects balance and motor skills. Twenty children aged 4 to 18 will receive either real or sham (fake) rTMS t…

This study looks at whether very small chest tubes (8 French, 12 French, and 14 French) can be used to deliver talc pleurodesis—a treatment that seals the space around the lungs to prevent fluid from building up again. The goal is to find the smallest tube that works well, causes…

This study tests a brief mindfulness-based lifestyle program (B-Mindful-Life) for caregivers of people with neurodegenerative disorders like Alzheimer's or Parkinson's. Many caregivers are physically inactive, raising their risk for heart disease and early death. The program uses…

This study tests whether a brief sleep therapy group, led by trained laypersons, can improve sleep quality in older adults in Hong Kong. Fifty participants aged 45 and older with mild depression and sleep problems will either join the group or receive a self-help booklet. The goa…

This study tests whether a nurse-led discharge program helps patients become more active in managing their own health after leaving the hospital. About 120 adults in Hong Kong who are stable enough to go home will take part. Researchers will measure changes in patient activation …

This study will see if a urine test for HPV is acceptable and effective for cervical cancer screening in community settings. About 8,620 women aged 26-65 will provide a urine sample at home or on-site. Those with positive results will get additional tests to see if a DNA methylat…

This study will test if a camouflaged WeChat mini-program is a feasible and acceptable way to support Chinese immigrant women in Hong Kong who have experienced intimate partner violence. About 86 women aged 18 to 45 will use the program and provide feedback. The goal is to see if…

This study tests a program called ChatACP that sends daily messages and uses a chatbot to help family members of nursing home residents learn about and start advance care planning. Researchers will compare this approach to standard materials and see if it makes families feel more…

This study will test a program that helps cancer survivors get more exercise. Doctors will assess, advise, and refer patients to a weight management program. The goal is to see if this approach can become a standard part of cancer care. About 1800 cancer survivors who have finish…

This study aims to create a risk index for postpartum depression using sleep data. Researchers will analyze sleep patterns from 60 Hong Kong mothers who wear a watch-like activity monitor for 14 days. The goal is to see if sleep changes can help identify those at risk for depress…

This study looks at kidney tissue from people with hepatorenal syndrome (HRS) who are getting a liver transplant. Researchers want to see if the kidney damage is permanent or reversible, which could change how doctors treat this condition. About 42 adults will take part, and they…

This study tests whether home visits from younger volunteers and AI-generated digital tools can encourage older adults (65+) in Hong Kong to join district health centres. Researchers will track how many people sign up and use the services over 3 months. The goal is to see if thes…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples with artificial intelligence. Researchers will track 15,000 healthy adults aged 40-70 over time to create personalized health baselines. The goal is to develop a sc…

This study follows 178 people who had their first episode of psychosis to see how early medication decisions and relapses affect their thinking, daily life, and mental health over 20 years. Participants will have one interview to assess symptoms, thinking skills, and well-being. …

This study tests a communication training program called ReFrame-R for Cantonese-speaking older adults in Hong Kong who have regular contact with their adult children. The goal is to see if the program helps them communicate better, feel more purposeful, and improve family relati…