Sound waves zapping liver tumours without a scalpel

NCT ID NCT06579833

Ongoing Disease control Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new, non-invasive treatment called histotripsy that uses high-intensity ultrasound waves to destroy liver tumours. It works by creating tiny bubbles in the tumour that burst and break it apart, while sparing healthy tissue. The trial will enroll 60 people with liver tumours (primary or metastatic) and monitor how well the treatment shrinks tumours and any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Histotripsy (high-intensity ultrasound waves)
What this could lead to: If successful, this could offer a non-invasive option to destroy liver tumours without surgery or radiation, potentially reducing recovery time and side effects.
What could go wrong: This is an early phase II study with only 60 participants, so results may not apply to all patients. The technique is new and long-term effectiveness or rare complications are not yet known.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma intrahepatic cholangiocarcinoma liver and intrahepatic bile duct neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER TUMOUR

Contacts and locations

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Locations

The University of Hong Kong

Hong Kong, 0000, Hong Kong

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