Boston Children's Hospital

This study compares two standard treatments for children and young adults with severe aplastic anemia, a rare disease where the body stops making enough blood cells. Researchers want to see if starting with a bone marrow transplant from an unrelated donor works better than starti…

This study aims to find the best way to give blood transfusions to young children on a life support machine called ECMO. Researchers are comparing two methods: one that gives blood only when there's a clear sign of bleeding or low oxygen, and another that uses a standard blood le…

This study is testing whether giving pediatricians a digital ear scope and/or personalized education helps them prescribe fewer antibiotics for children's ear infections. It involves 40 doctors who currently prescribe antibiotics for ear infections at high rates. The goal is to s…

This study aims to improve treatment for babies with hydrocephalus (fluid buildup in the brain) in Uganda. Researchers are testing a brain surgery technique that could allow babies to live without needing a permanent shunt device, which often fails. The study will follow 400 infa…

This study aims to see if people with a specific gene variant (IL-4RαR576) respond better to the asthma drug dupilumab. About 150 participants, ages 12 and older with moderate-to-severe asthma, will receive either the drug or a placebo for 48 weeks. The main goal is to see if the…

This study is observing children with short bowel syndrome for an extra 90 days to see if a device called Relizorb is safe and helps them absorb fat from tube feeding. The device attaches to a feeding tube and predigests fat, which could help kids rely less on risky intravenous (…

This study is testing whether a remote support program using video counseling and a smartphone app can help young adults reduce their cannabis use and related problems. Researchers will compare this program to a brief counseling session alone. The main goals are to see if the pro…

This early-stage study is checking if metformin, a common diabetes medication, is safe and practical to give to infants who suffered brain injury from lack of oxygen at birth. The goal is to see if this drug could help improve brain development in these babies, who remain at high…

This study is testing a new, gentler bone marrow transplant procedure for people with dyskeratosis congenita, a rare genetic disorder that causes bone marrow failure. The standard transplant uses harsh drugs and radiation that can worsen lung/liver disease and cancer risk in thes…

This study is testing whether giving a medication called omalizumab to 2-3 year old children at high risk for asthma can prevent them from developing the condition. About 200 children will receive either the real medication or a placebo for two years, followed by two years of obs…

This study is testing whether a 6-week online education program can help Boston Marathon runners better understand and manage knee pain. Researchers will compare pain levels, function, and marathon performance between runners who receive the program before the race and those who …

This study aimed to compare two types of nerve blocks used alongside a standard pain control method for teenagers and young adults having major hip surgery. The goal was to see if one block was better at reducing pain and the need for opioid painkillers after surgery. The study w…

This study planned to test if a TENS device, which uses gentle electrical pulses on the skin, could reduce chronic pelvic pain and improve daily life for teens and young women with endometriosis. It aimed to enroll participants aged 13-25 who had significant pain. However, the tr…

This study aims to learn more about autism by collecting detailed information from families. Participants, including children with autism and their family members, complete interviews, assessments, and provide blood samples. The goal is to find connections between genetic factors…

This study aims to understand how stress affects the brain and body in young people (ages 11-17) with chronic widespread pain. Researchers will measure brain activity, stress hormones, and other body functions in 70 participants to learn how these factors relate to pain and disab…

This study aims to understand why some patients develop infections after surgery by examining differences in their immune cells. Researchers are comparing 220 patients undergoing gastrointestinal or spine surgery to see if specific immune cell patterns predict infection risk. The…

This study aims to understand how the immune system works in people with inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and other related conditions. Researchers will collect blood and tissue samples from about 1,000 participants, including patients and healt…

This study aims to find out if a detailed set of heart catheterization tests can predict what will happen to a child's narrowed lung veins one year later. Researchers will perform special imaging and pressure tests on 80 children with this condition during their standard care. Th…

This study is testing a 4-week educational workshop designed to help caregivers in families who struggle to get enough healthy food. Researchers want to see if the workshop improves a family's food security and the caregiver's knowledge and skills for accessing nutritious meals. …