Boston Children's Hospital

This study tests whether removing Staphylococcus aureus bacteria from the skin can reduce eczema severity in 100 people aged 6 and older with moderate-to-severe atopic dermatitis. Participants will undergo a decolonization protocol, and researchers will measure changes in disease…

This study looks at whether eating foods that bind to bile acids can reduce bile levels in the stomach and saliva of children who rely on feeding tubes. High bile acids can lead to breathing complications if inhaled. Over four weeks, 66 children aged 5 to 21 will try two differen…

This study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with social difficulties will take either everolimus or a placebo for 6 months,…

This study gives children with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. Researchers want to see if this program helps kids eat more produce and improves their heart health over 6 to 12 months…

This study looks at whether a diet with foods that bind to bile acid can reduce hospital and emergency room visits in children who rely on feeding tubes and are at risk for breathing problems from aspiration. About 138 children will be assigned to one of three diets and followed …

This study tests whether reducing radon gas in homes can improve asthma symptoms. Researchers will enroll 180 adults with uncontrolled asthma and measure how many days they have symptoms after radon mitigation. The goal is to see if a simple home fix can help manage the disease.

This study tests a new bedside blood test that may quickly tell if a child is having a stroke. Researchers will check how accurate the test is in 250 children who come to the ER with stroke symptoms. The goal is to speed up diagnosis and treatment, while children still receive st…

This study looks at whether training primary care doctors to diagnose autism in children aged 18 to 36 months can shorten the time from a positive screening to a final diagnosis. About 300 children will take part across multiple clinics. Some doctors will receive special training…

This study tests a one-on-one coaching method called academic detailing to help pediatricians feel more comfortable prescribing PrEP, a daily pill that prevents HIV. Fifty doctors will take part in brief, interactive sessions with trained educators. The goal is to see if this app…

This study tests whether adding valproate (a medication) to standard patching therapy can improve vision in children aged 8-17 with lazy eye (amblyopia) that hasn't fully resolved. Participants will take valproate or a placebo daily for 16 weeks while patching the stronger eye fo…

This study looks at whether one session of intense aerobic exercise can lower pain sensitivity in teens with chronic pain. Researchers will compare pain responses in 66 youth with and without chronic pain before and after treadmill exercise. If effective, exercise could become a …

This study looks at different combinations of two sedative medicines, propofol and dexmedetomidine, to find the best way to sedate children aged 1 to 12 for MRI scans. The goal is to use less propofol, which may have risks, while keeping children comfortable and not slowing their…

This study compares two medications, gabapentin and oxcarbazepine, to see which one works better for reducing chronic nerve pain in children and teens aged 8 to 18. The goal is to find a treatment that lowers pain scores and improves daily life. Participants will be randomly assi…

This early-stage study tests whether adding hydrogen gas to standard cooling therapy is safe and doable for newborns who suffered brain injury from oxygen loss at birth. About 54 full-term infants will be randomly assigned to receive either standard cooling alone or cooling plus …

This study looks at whether giving ketamine within the first hour of a sickle cell pain crisis can lower the chance of being admitted to the hospital. About 90 children and young adults aged 6 to 24 will receive either ketamine or a placebo by mouth. The goal is to see if early t…

This study tests whether adding virtual reality (VR) to standard treatments like therapy and biofeedback can help teens with chronic dizziness. The idea is that VR can safely recreate the visual triggers that cause dizziness, helping the brain relearn how to handle balance cues. …

This study looks at whether mental skills training (MST) can improve coping and psychological readiness in young athletes returning to sports after ACL reconstruction. About 130 participants aged 8 to 25 will be split into two groups: one receiving MST sessions before and after s…

This study looks at how three common anesthesia drugs (fentanyl, rocuronium, and atropine) behave in fetuses during maternal-fetal surgery. Researchers will measure drug levels in discarded fetal blood samples and link them to heart rate, movement, and other factors. The goal is …

This study will test a phone app called MyMedDiary in 120 children (ages 2-18) who were just diagnosed with celiac disease. The app helps families track what they eat and find hidden sources of gluten. Researchers want to see if using the app leads to better gluten-free diet habi…

This study looks at whether a specially designed AI model can help emergency room doctors make fairer decisions about which patients need to be admitted to the hospital. Researchers will ask ER doctors to predict a patient's admission risk before and after seeing the AI's suggest…

This study will test a handheld device called Intra.Ox that uses light to measure oxygen levels in the heart and other organs during complex heart surgery in children. The goal is to see if this device can give surgeons quick, useful information about blood flow to help make bett…

This study looks at whether a special mobile app can reliably send blood sugar readings from continuous glucose monitors (CGMs) used by children with diabetes in the hospital to a central database. The goal is to make it easier for doctors and nurses to see the data live, which c…

This study will use a handheld camera to look at the smallest blood vessels in children undergoing heart surgery for tetralogy of Fallot or a hole in the heart. The goal is to see if these tiny vessels behave differently from the larger ones doctors usually monitor, which could h…

This study will see if using a digital otoscope (a camera that takes pictures of the eardrum) helps doctors diagnose ear infections more accurately and prescribe fewer unnecessary antibiotics. Four pediatric clinics in Massachusetts will take part, with two using the digital tool…

This study looks at whether certain proteins in the blood can show if a child's brain has been injured during heart surgery. It will include 100 children under 18 who need heart surgery with a heart-lung machine. The goal is to better understand and detect brain injury after thes…

This study aims to validate a questionnaire called VM-PATHI for adolescents aged 10-20 with vestibular migraine, a condition causing dizziness and other symptoms. Researchers will check if the tool accurately measures symptom severity and can detect meaningful changes. About 70 p…

This study tests a new computer program designed to help autistic children ages 8-11 improve their ability to control thoughts and actions, which may reduce repetitive behaviors. About 95 children will be randomly assigned to receive the training right away or after a delay. Rese…