Boston Children's Hospital

This study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with PHTS and social difficulties will take either everolimus or a placebo for …

This study will give 150 children and teens with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. The goal is to see if this program helps improve their heart health over 6 to 12 months. Participants…

This study tests whether clearing Staphylococcus aureus bacteria from the skin can reduce eczema severity in people with atopic dermatitis. Researchers will enroll 100 participants aged 6 and older with moderate-to-severe disease. The goal is to see if decolonization improves ski…

This early-phase trial tests whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns who suffered brain injury from lack of oxygen at birth (HIE). About 54 infants will be randomly assigned to receive either standard cooling alone or cooling plus…

This study tests whether installing a radon mitigation system in homes can improve asthma symptoms. Researchers will compare a real system to a sham (inactive) system in 180 adults with uncontrolled asthma. The goal is to see if lowering radon levels leads to fewer days with asth…

This study looks at whether a diet with foods that bind bile acids can lower the number of hospital and emergency room visits for children who rely on feeding tubes and are at risk for breathing problems from food or liquid entering the airway. About 138 children will be assigned…

This study tests whether foods that bind bile can reduce bile acid levels in the stomach and saliva of children aged 5 to 21 who rely on feeding tubes. High bile levels can lead to lung irritation if accidentally inhaled. For two weeks, participants will eat a high bile-binding d…

This early-stage trial tests whether adding the drug valproate to standard patching therapy can improve vision in children aged 8 to 17 with lazy eye (amblyopia). Participants will take valproate or a placebo daily for 8 weeks while patching the stronger eye. The study aims to se…

This study will test a new rapid blood test that can be done at the bedside to help doctors quickly tell if a child is having a stroke. About 250 children with stroke symptoms will give a small blood sample, and the test's accuracy will be compared to standard brain scans. The go…

This study looks at whether a one-on-one coaching method called academic detailing can help pediatricians feel more comfortable prescribing PrEP, a daily pill that prevents HIV. Fifty doctors will take part in brief, interactive sessions with a trained educator. The goal is to se…

This study tests whether mental skills training (MST) can improve coping and psychological readiness in 130 young athletes (ages 8-25) recovering from ACL reconstruction. Half will receive MST sessions before and after surgery; the other half will not. Researchers will measure co…

This study tests whether giving ketamine within an hour of pain onset can prevent hospital admission for children and young adults with sickle cell disease. 90 participants aged 6-24 will receive either ketamine or a placebo by mouth. If admitted, they can still receive standard …

This early-phase trial at Boston Children's Hospital will test whether adding virtual reality (VR) to standard treatments like biofeedback and cognitive behavioral therapy can help 12 adolescents with chronic dizziness. The goal is to see if VR can safely and feasibly reduce dizz…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests a wireless, sticky ultrasound patch that sticks to a pregnant woman's belly to monitor her baby's health. The patch records images and data for 10 to 30 minutes. Researchers want to see if the patch is comfortable, stays in place, and provides good-quality images…

This study looks at whether a small pressure sensor placed in the leg during surgery can help doctors spot a rare but serious problem called acute compartment syndrome. Teens aged 10 to 21 with a broken shinbone will have the sensor monitor pressure for at least 18 hours after th…

This study tests whether a simple, non-invasive brain test (EEG) can predict which of two common ADHD medications—methylphenidate or amphetamines—works best for a child. About 220 children aged 7-11 with ADHD will try both medicines in a random order over 7 weeks. The goal is to …

This study checks whether three common ECG-based methods can accurately locate where abnormal heart rhythms start in adults who had Tetralogy of Fallot repair. Researchers will pace the heart from known spots during a scheduled procedure and compare the predicted location to the …

This study will measure how three common anesthesia drugs—fentanyl, rocuronium, and atropine—behave in fetuses during maternal-fetal surgery. Researchers will analyze discarded fetal blood samples and track heart rate and movement to understand drug effects. The goal is to create…

This study tests a new computer-based training program designed to help autistic children ages 8-11 improve their thinking and problem-solving skills. The goal is to see if this training can reduce repetitive behaviors and improve daily functioning. 95 children will be randomly a…

This study aims to validate a questionnaire called VM-PATHI for adolescents aged 10-20 with vestibular migraine, a condition causing dizziness and other symptoms. Researchers will test whether the tool accurately measures symptom severity and meaningful improvement. About 70 part…

This study tests whether a machine learning model, designed to be fair across different patient groups, can influence how ER doctors predict which patients will be admitted. Ten board-certified ER doctors at Boston Children's Hospital will review patient data and give their admis…

This study tests a companion mobile app that wirelessly collects real-time glucose readings from Dexcom G7 continuous glucose monitors (CGMs) used by children with diabetes in the hospital. The app sends the data to a central hospital database, making it accessible to care teams …

This study looks at whether certain proteins in the blood can signal brain injury in children who have heart surgery with a heart-lung machine. Researchers will measure these proteins before and after surgery and compare them to the child's brain function. The goal is to find a s…

This study looks at whether training primary care clinicians to diagnose autism in children aged 18 to 36 months can shorten the time from a positive screening to a final diagnosis. About 300 children will take part across multiple clinics. Researchers will compare diagnosis time…

This study will test a handheld device called IntraOx that uses light to measure oxygen levels in heart and liver tissue during complex heart surgery in children. The goal is to see if it can give surgeons useful information about blood flow without interfering with the operation…

This study tests a digital diary called MyMedDiary in 120 children (ages 2-18) newly diagnosed with celiac disease. The app helps families track gluten-free foods and spot hidden sources of gluten. Researchers want to see if the app improves diet adherence compared to traditional…

This study looks at whether a single session of intense aerobic exercise can temporarily reduce pain sensitivity in 66 young people with and without chronic pain. Participants will walk or run on a treadmill, and researchers will measure how their pain perception changes. The goa…