HEMATOPOIETIC AND LYMPHATIC SYSTEM NEOPLASM

This study is testing a refined procedure for umbilical cord blood transplants in adults and children with high-risk blood cancers like leukemia and lymphoma. The goal is to see if this optimized approach improves survival and reduces complications compared to standard transplant…

This study is testing whether taking daily fiber supplements can help patients undergoing a donor stem cell transplant for blood cancers. The goal is to see if fiber improves overall nutrition and supports healthy gut bacteria during this difficult treatment. Researchers will tra…

This study is testing if the antiviral drug remdesivir can safely treat RSV (a common respiratory virus) in adults with weakened immune systems. Participants are people with cancer or autoimmune diseases who recently received treatments like stem cell transplants or specialized a…

This study is testing a modified, two-step stem cell transplant procedure designed to be safer. It aims to reduce deaths caused by the transplant treatment itself in patients with various blood cancers and disorders. The trial compares two gentler preparation methods using lower …

This study is testing whether a drug called triptorelin can protect the ovaries in young women and adolescents receiving chemotherapy for cancer. Chemotherapy can damage the ovaries, which may make it difficult or impossible to have children later. Researchers want to see if givi…

This study is testing whether adding a drug called siltuximab can help cancer patients safely restart a type of immunotherapy that previously caused them severe side effects. The trial will enroll 40 adults with advanced cancer who had to stop their original immunotherapy due to …

This study tests whether injecting three medications directly into the spinal fluid can prevent severe brain-related side effects in patients receiving CAR-T cell therapy for blood cancers. CAR-T therapy can cause dangerous neurological complications in 20-70% of patients, rangin…

This early-stage study is testing a new oral medication called Q702 for patients with advanced blood cancers and rare immune cell disorders that have not responded to standard treatments. The main goals are to find the safest dose and see what side effects occur. Researchers hope…

This early-phase trial is testing a new combination of two drugs, temozolomide and M1774, for people with advanced cancers that have spread. The main goals are to find the safest and most effective dose and to see if the combination can shrink or stabilize tumors, especially in a…

This study is testing a new approach to detect cancer early using simple blood and urine tests. Researchers want to see if these tests can accurately find cancer and even identify where in the body it started. The study will involve 6150 people, including those with and without c…

This early-stage trial is testing a new vaccine designed to prevent serious cytomegalovirus (CMV) infections. The study involves patients with blood cancers who are receiving a stem cell transplant from a partially matched donor, a procedure that carries a high risk of CMV. Resea…

This study is testing if a drug called ibrutinib can prevent chronic graft-versus-host disease (GVHD) in patients who have received a donor stem cell transplant. GVHD is a serious condition where the donor's immune cells attack the patient's body. The trial will enroll 40 adults …

This study is testing whether an online mindfulness program can help reduce stress and anxiety in cancer patients who live in rural Minnesota, where mental health services are harder to access. The program teaches techniques to help manage stress from home. Researchers will measu…

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing whether creative arts activities like drawing, painting, and making sculptures can help improve symptoms and quality of life for children with cancer. Researchers will compare children doing art activities with children watching videos to see which approach …

This study tests whether a telehealth program can help reduce stress, depression, and financial strain for people caring for loved ones undergoing a major cancer surgery and heated chemotherapy. Researchers will enroll 50 caregivers and provide half with a one-hour virtual sessio…

This study is testing whether a short virtual therapy program can better reduce depression and anxiety in young cancer survivors compared to usual care. The therapy focuses on building hope and strengths rather than just discussing problems. Researchers will enroll 60 survivors a…

This study is testing two tools to help blood cancer survivors plan for their future medical care. It involves a special website and sessions with a health coach to guide conversations about treatment preferences. The goal is to see if these tools make it easier for patients to d…

This study aims to see if American ginseng can help reduce the severe fatigue that many cancer patients experience, whether they are currently on treatment or not. It will compare ginseng capsules to a placebo (a dummy pill) in 160 adults with solid tumors who report significant …

This early-stage study is testing whether L-Theanine, a natural compound found in green tea, can help cancer survivors feel more relaxed and improve their mood. Researchers will enroll 50 adults who have finished cancer treatment and are now in the monitoring phase. Participants …

This study is testing whether a phone app can teach family caregivers safe massage techniques to help cancer survivors manage long-term nerve pain and numbness caused by chemotherapy. The goal is to see if this at-home care can reduce symptoms for patients and make caregivers fee…

This study is testing whether acupressure, a technique using finger pressure on specific body points, can help reduce anxiety in people receiving chemotherapy for cancer. Researchers will compare real acupressure to a 'sham' version in 78 adult cancer patients who report signific…

This study is testing a home-based fitness program designed specifically for Hispanic and Latino young adults who survived childhood cancer. The program uses a Fitbit, a mobile app, and a private social media group to encourage physical activity. Researchers want to see if this c…

This study is testing if a virtual diet coaching program can help reduce nerve pain and numbness caused by chemotherapy. Researchers want to see if a diet low in sugar and high in fiber and healthy fats is practical and acceptable for cancer survivors. The main goal is to check i…

This study is testing if a virtual exercise program can be successfully delivered to people receiving chemotherapy for cancer. The goal is to see if exercising at home can help patients manage common treatment side effects like fatigue and loss of strength. The program includes s…

This study is testing phone-based support programs to help people manage the side effects and emotional distress that often come with taking oral cancer medications at home. Researchers are comparing two approaches: one involves weekly check-in calls that report symptoms to docto…

This study tests a digital coaching program called ASCENT to help cancer survivors manage their pain better. Participants receive personalized guidance from health coaches and learn pain management techniques through phone or video calls. The goal is to improve pain control while…

This study is testing whether different types of massage can help reduce anxiety for cancer patients while they receive chemotherapy. Researchers will enroll 50 patients to try massages on areas like the feet, head, or hands during their infusion sessions. The main goal is to see…

This study is testing whether a supervised community exercise and nutrition education program is practical and helpful for people who have finished cancer treatment. Over 12 weeks, participants will do twice-weekly workouts and learn about healthy eating to see if it improves the…

This study is testing whether a virtual art therapy program can help young adult cancer survivors cope with emotional challenges like anxiety and depression. Researchers want to see if this online approach is practical and helpful for participants aged 18-25. The program involves…

This study is testing a web-based toolkit called CONNECT, designed to help older cancer survivors living in rural areas manage the emotional distress and anxiety that can follow cancer treatment. The program provides interactive activities, helps set up telehealth visits, and off…

This study is testing special hospital rooms equipped with sensors, cameras, and microphones to monitor cancer patients. The goal is to see if this technology can spot early signs of problems like confusion, falls, or sleep issues before they become serious. Researchers hope this…

This study aims to find people at risk for developing blood cancers and bone marrow failure syndromes before they get sick. Researchers will use advanced genetic testing on blood, bone marrow, and saliva samples from up to 2,000 participants. The goal is to identify early warning…

This study collects leftover tissue and blood samples from cancer patients during their normal medical procedures. The samples are stored and used to create living cancer models in the lab. These models help scientists better understand cancer and test potential new drugs, but pa…

This study aims to understand genetic factors in cancer among Indigenous American communities to improve cancer screening and treatment. Researchers will analyze tumor samples and genetic material from 300 Indigenous American adults with cancer or cancer history. The goal is to d…

This study is testing a new digital tool called SALSA to see if it can spot thinking and memory problems early in cancer patients receiving a powerful immunotherapy called CAR-T. Researchers will compare the tool to standard check-ups in about 38 adults getting CAR-T treatment in…

This study aims to see if educational materials like videos and pamphlets can improve cancer patients' knowledge and beliefs about clinical trials. It will enroll 50 adult patients with various cancer types. Researchers will measure changes in understanding by having participants…

This study aims to understand why some cancer patients develop heart problems after chemotherapy while others do not. Researchers will collect blood samples and review medical records from 1,000 patients who either experienced heart issues after treatment, are at high risk, or fi…

This study is testing whether a virtual community health educator—a photo-realistic digital guide—can help more cancer patients and their caregivers get referred to clinical trials. It focuses on increasing participation from groups that are often underrepresented in research. Th…

This study aims to understand if men and women experience the side effects of cancer immunotherapy differently. It will also compare how patients report their symptoms versus how their doctors assess them. Researchers will observe 100 adults with various cancers who are starting …

This Mayo Clinic study explores how sharing messages of wisdom and hope affects the sense of dignity in cancer patients and their caregivers. Forty participants with cancer and their caregivers will record messages about their experiences and complete surveys about dignity before…

This study aims to understand the connection between physical activity and memory or thinking problems (sometimes called 'chemo brain') in young adults who have finished cancer treatment. Researchers will enroll 100 survivors aged 18+ who were diagnosed between ages 15-39. Partic…

This study aims to predict which cancer patients might experience serious side effects from their treatments. Researchers will take blood samples from 30 adult cancer patients and turn their cells into heart and nerve cells in the lab. By testing these lab-grown cells with cancer…

This study aims to understand how a doctor's behavior and other aspects of care affect emotional distress in cancer patients. Researchers will survey 5,000 adults undergoing or recently finished with radiation therapy at Mayo Clinic. The goal is to identify what specific doctor a…

This study aims to learn how often and in which children a leukemia drug causes a dangerous buildup of ammonia in the blood. Researchers will observe 10 pediatric patients receiving the drug Rylaze®. They will track who develops this condition by checking blood ammonia levels mul…