END-STAGE RENAL DISEASE

This study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…

This study looks at two common heart medications, metoprolol and carvedilol, in people on dialysis. The goal is to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 adults on hemodialysis will be randomly assigned to one of the two drugs …

This study looks at two types of immunosuppressant drugs in kidney transplant patients: belatacept and anticalcineurins. The goal is to see if belatacept improves blood vessel function better than anticalcineurins, which are linked to heart problems. About 44 adults who have had …

This study tests a special wrap called SelfWrap that is placed around blood vessels during surgery to create a connection for dialysis. The wrap helps the vessels grow strong and work well without extra procedures. About 600 adults with advanced kidney disease who need a new dial…

This study tests whether a single injection of Berinert (a C1 esterase inhibitor) into a deceased donor kidney before transplant can improve kidney function in the first year after surgery. About 180 adults on dialysis waiting for a kidney transplant will participate. Half will r…

This study tests a device that uses automated ultrasound to check how well a dialysis fistula (a surgically created blood vessel connection) is maturing in people with end-stage kidney disease and diabetes. About 304 participants will be randomly assigned to get biweekly automate…

This study follows 150 people who received imlifidase before a kidney transplant to see how long their new kidney works. Researchers will check for graft failure (return to dialysis, re-transplant, or kidney removal) over 5 years. A separate group of similar patients not receivin…

This study compares a once-daily anti-rejection drug (Envarsus XR) to the standard twice-daily drug in 78 adults receiving a kidney transplant. The goal is to see if the once-daily option reduces hidden rejection and improves immune system markers. Participants will be followed f…

This study tests whether kidney transplants from HIV-positive donors are safe and effective for people with HIV and end-stage kidney disease. About 30 adults with well-controlled HIV will receive a kidney from an HIV-positive donor. Researchers will track survival and kidney func…

This study tests whether a blood filtering procedure called rheopheresis can help heal severe skin wounds caused by calciphylaxis, a rare and painful condition in people on dialysis. About 138 adults with end-stage kidney disease and at least one open wound will receive the treat…

This study is testing a device called the BD WavelinQ EndoAVF System, which creates a connection between an artery and a vein (called a fistula) in people who need dialysis. The goal is to make it easier and safer to start dialysis. About 280 adults with end-stage kidney disease …

This study tests whether a personalized sodium (salt) management feature on dialysis machines can help people with end-stage kidney disease. It compares the new approach to standard dialysis in 130 adults. The goal is to see if it reduces weight gain between sessions, improves fl…

This study tests a device that helps people on dialysis get needle access through a vein connection in their arm (called a fistula). The device is for patients whose fistulas are too deep to easily reach. The goal is to see if the device works well and is safe over 6 to 12 months…

This study tests the safety and early effectiveness of empagliflozin, a diabetes medicine, in 60 adults who are just starting hemodialysis for end-stage kidney disease. Participants will receive either the drug or a placebo for 12 weeks. The goal is to see if empagliflozin helps …

This study tests a device called VasQ that is placed around a blood vessel connection (fistula) used for dialysis in people with kidney failure. The goal is to see if VasQ helps the fistula work well enough for dialysis sooner and for longer compared to standard fistula creation.…

This study tests a new dialysis solution called XyloCore, which uses less glucose than standard fluids, in 170 adults with end-stage kidney disease on peritoneal dialysis. The goal is to see if it cleans the blood just as well while possibly improving sugar and fat levels. Partic…

This study looks at whether adding CoQ10 (a supplement that supports cell energy) to high-intensity interval training can help people with end-stage kidney disease build muscle and improve physical function. 156 adults on dialysis will be assigned to exercise alone or exercise pl…

This study tests a drug called pegcetacoplan in 320 adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). The goal is to see if the drug helps the kidney work sooner and r…

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns to guide how much fluid is taken out. The goal is to reduce dangerous drops in blood pressure during treatment while still controlling fluid buildup. The study…

This study looks at whether the blood thinner warfarin is safe and effective for people with kidney failure on dialysis who also have atrial fibrillation (an irregular heartbeat). The goal is to see if warfarin can reduce the risk of stroke without causing dangerous bleeding. Abo…

This study tests an experimental drug called DCR-PHXC in 28 people with primary hyperoxaluria type 1 (PH1) who have severe kidney damage, whether or not they need dialysis. The goal is to see if the drug can safely lower oxalate levels in the blood, which may help control the dis…

This study tests whether a special app and home monitoring device can help people with advanced chronic kidney disease (stage 5) avoid emergency room visits and hospital stays. About 340 adults will either get usual care or use the VIEWER platform to track their weight and blood …

This study tests whether adding sodium thiosulfate to the fluid that keeps donated kidneys cold and healthy before transplant can reduce the chance of delayed function. About 120 adults receiving a deceased-donor kidney will be randomly assigned to get the additive or standard ca…

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease who need regular hemodialysis. The goal is to see if it is safe and works well at cleaning the blood. About 46 adults who are either new to dialysis or already on it will t…

This study looks at whether a special ultrasound inside the vein (IVUS) can better detect narrowing caused by long-term dialysis catheters compared to the usual X-ray method. About 50 adults with kidney failure who are on dialysis and have access problems will take part. The goal…

This early-stage study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and brain fog in people with end-stage kidney disease. About 28 adults on regular hemodialysis will receive either a single amino acid (valine) or a mix of essential am…

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests a program called CAPABLE Transplant to help people on the kidney transplant waitlist become active again and improve their quality of life. It includes 43 adults who are either inactive on the waitlist or active but low-income. The program addresses barriers like…

This study looks at whether a new type of dialysis filter can help reduce common symptoms like pain, poor sleep, low energy, and itching in people with end-stage kidney disease. About 100 adults on regular dialysis will use a phone app to track how they feel over 28 weeks. The go…

This study tests whether bright light therapy can help reduce fatigue in people with end stage kidney disease who are on hemodialysis. About 60 adults will wear special glasses that give off bright light for one hour during their dialysis sessions, for four weeks. The goal is to …

This study tests a 13-week program teaching dialectical behavioural therapy (DBT) skills to help adults on hemodialysis manage anxiety and improve mental well-being. About 35 participants who recently started dialysis or plan to start soon will join. The program will be offered i…

This study tests whether having dialysis patients regularly report their symptoms electronically, with results sent to their care team, can improve their quality of life. About 2,293 adults with end-stage kidney disease on dialysis will take part across French clinics. The goal i…

This study tests whether magnetic stimulation can reduce low back pain and help maintain muscle mass in people with end-stage kidney disease who are on dialysis. About 18 adults with moderate to severe back pain will receive the treatment. The goal is to improve pain, physical fu…

This study looks at whether a 6-week aerobic exercise program can lower uric acid levels and improve daily function and quality of life in 32 adults aged 40-60 who are on hemodialysis. Participants will either do structured exercise or receive standard care. The goal is to find a…

This early-stage study looks at how the drug MK-2828 is processed in people with different levels of kidney function, including those on dialysis. Researchers will compare these results to healthy volunteers to see if kidney disease changes drug levels. The goal is to gather info…

This study looks at whether the sounds made by blood flowing through an arteriovenous fistula (a special blood vessel connection used for dialysis) can tell doctors about the health of that connection. Researchers will measure blood flow patterns and record sounds in 15 adults wi…

This study looks at how people with end-stage kidney disease manage sodium levels when given extra water or salt. Researchers want to understand why current formulas don't always predict sodium changes accurately. The goal is to improve care for hyponatremia, a common and dangero…

This study tests whether a quick neck ultrasound can accurately measure fluid levels in people on chronic haemodialysis. Researchers will compare the ultrasound results with standard methods in 100 participants. The goal is to find a simpler, non-invasive way to guide fluid remov…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study looks at how inflammation from conditions like type 2 diabetes, irritable bowel syndrome, and end-stage kidney disease might change the way the body processes certain drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation mar…

This study collects health data from 60,000 people with kidney disease who are seen by a kidney specialist. The goal is to understand how heart problems and kidney disease affect each other, and to find better ways to predict and treat these conditions. No new treatments are test…